The Purdue Boilermakers (2-8, 0-7 Big Ten) take on the Washington Huskies (6-3, 3-3 Big Ten) in Seattle, Washington. Kickoff is set for 7:00 p.m. EST on Fox Sports 1.
Washington is favored by 16.5 points on the spread with a moneyline of -900. The total is set at 51.5 points.
Here’s my Purdue vs. Washington prediction and college football picks for Saturday, November 15, 2025.
Purdue vs Washington Prediction and Picks
- Purdue vs. Washington Pick: Washington 2H -6.5 (-125)
My Washington vs. Purdue best bet is on the Huskies to cover the second-half spread. Find the best line available on our live NCAAF odds page.
Purdue vs Washington Odds, Money Line, Spread, Over/Under
| Purdue Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+16.5 -108 | 51.5 -110o / -110u | +600 |
| Washington Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-16.5 -112 | 51.5 -110o / -110u | -900 |
- Purdue vs Washington point spread: Washington -16.5 (-112), Purdue +16.5 (-108)
- Purdue vs Washington over/under: 51.5 (-110o / -110u)
- Purdue vs Washington moneyline: Purdue +600, Washington -900
Purdue vs Washington Game Preview
Purdue Boilermakers Betting Preview: Subpar Defense
The middle stretch of the season has been an absolute slog for Purdue.
The Boilers have lost eight straight games, all against Power Conference teams, and are finishing up seven consecutive conference games without a bye week. That kind of stretch adds up.
Purdue heads to Washington (over 2,100 miles and three time zones away) to cap the run. As a cherry on top, that succeeds back-to-back games against Michigan and Ohio State.
Last week's final against the Buckeyes wasn't nearly as bad as the game itself. Purdue scored late to cover its tracks in a 34-10 loss, but in reality, Ohio State could have scored a bunch more if not for a pick thrown around the goal line, a touchdown called back on its first offensive play, and a play script so vanilla you'd have thought it was reused from spring practice. Ohio State was also down a first-round talent at receiver.
Despite the 2-8 record, Purdue's been feisty. It dueled to a one-score finish with Michigan, Minnesota, and Rutgers, and held its own for a half against Notre Dame.
But talent wins out, and Purdue is always out-talented in the Big Ten.
Quarterback Ryan Browne has done the best he can with what he's surrounded by. He's good at extending plays with his feet, but will offset that ability by putting the ball in harm's way, trying to make something happen. He's a one-read quarterback who will force the ball to his first option, resulting in turnovers.
Running back Devin Mockobee has missed the last two games, which really nerfs the explosive potential on the ground. Coordinator Josh Henson's scheme does a good job of offsetting a subpar offensive line and opening up gaps for backs, but behind Mockobee isn't much talent, and the Boilermakers' run game has suffered.
Purdue's defense benefits from playing turnover-prone teams and run-heavy offenses. A four-game stretch before the Ohio State game saw Purdue hold opponents to under 30 each time. Perhaps holding the Buckeyes to 34 appears admirable, too.
However, the reality is that this defense isn't as good as advertised.
It ranks 122nd nationally in Success Rate allowed. The secondary isn't overly talented, and it's a poor tackling team all around. The Mike Scherer defense can, at times, generate pressure with creative blitz schemes — Purdue sacked Julian Sayin last week, just the fourth time that happened all year — but when that doesn't work, it's tough slowing down talented offenses.
Talented offenses are all that's left on the slate. Purdue heads out to Washington (fifth in Success Rate) and closes with the Old Oaken Bucket game against Indiana (second).
Washington Huskies Betting Preview: Much Better at Home
Relying solely on late-game heroics was playing with fire, and Washington finally got burned.
The Huskies were downright sloppy on a cold day in Madison, a day that turned miserable for them as Washington was upset by Wisconsin, 13-10.
Washington was without Jonah Coleman for most of the game, and it hurt. Quarterback Demond Williams led the rushing attack with 61 yards, followed by 54 yards from Adam Mohammed. Without a huge threat in the run game, Wisconsin was able to pin its ears back and send the pressure on Williams, who had to get rid of the ball quickly or pay the consequences. He was sacked four times on 24 pressures.
It appears to be a home/away thing for the Huskies. They're a completely different football team on the road than at home. In Big Ten play, Washington averages 13.7 points per game on the road (21 of the 41 points came in a late fourth-quarter scramble at Maryland) against 28.7 points per game at home, including an outlier six against Ohio State.
That home/away split is a continuation from last year under Jedd Fisch, too. Washington won all six games at home and, before Week 5 against Ohio State, hadn't lost at home since 2021 (24-1 since 2021).
Fortunately for Washington, it hosts Purdue this weekend and Oregon to close the year.
While the offensive output swings wildly depending on game location, the defense has been pretty consistent. On the whole, Washington's defense appears fine (21.3 points allowed per game, ranks 25th), but the bend-don't-break approach leads to long drives for opposing offenses.
The Huskies are good at holding teams to three points on those drives. But when the offense isn't humming, the defense doesn't get off the field enough, limiting scoring opportunities.
Teams find success on late downs and drives extend. It's a compounding problem that hasn't yet been solved.
Washington is a team with an extremely high ceiling, but it hasn't put together a complete game often enough. It beat Illinois 42-25 in a good display, but that's offset by 10- and six-point performances against Wisconsin and Michigan, respectively.
Who's to say this team won't trip up at UCLA next week?
How To Make Purdue vs Washington Picks
Washington opened as a 15.5-point home favorite over Purdue this weekend. The market slightly favors Washington, who moved up to -16.5 and the under, which moved through 52 (not an insignificant move!).
The story this year has been Washington's slow starts.
Against Washington State, the Huskies dropped 28 points in the fourth quarter to break open a 31-24 game to 59-24. Two weeks later, Washington erased a 20-3 deficit at Maryland to win 24-20 in the fourth. Washington used 14 final-quarter points to clean up a 28-17 lead over Illinois.
But last week, that second-half surge never came, and Washington dropped that 13-10 stinker.
This week, I'm back on the Washington second-half well for two reasons: the Washington offense performs much better in the friendly confines of Husky Stadium, and Purdue is wrapping up a long stretch where it's been beat up by conference opponents and is eyeing a much-needed bye week. It's the end of the stretch — the light at the end of the tunnel — for the 2-8 Boilermakers.
Coleman is questionable, but was comfortable enough testing his injured knee out against the Badgers. It seems more likely he plays here than not.
That injection back into the offense should get Washington pointed in the right direction.
As long as you can find better than -7, I'm taking the Huskies to cover the second half as they've done most every game this year.
Pick: Washington 2H -6.5 (-125, DraftKings)
