The Notre Dame Fighting Irish take on the Pittsburgh Panthers in Pittsburgh, Pennsylvania. Kickoff is set for 12:00 p.m. EST on ABC.
Notre Dame is favored by 12.5 points on the spread with a moneyline of -455. The total is set at 54.5 points.
Here are my Pitt vs Notre Dame picks and same-game parlay for Saturday, November 15, 2025.
Notre Dame vs Pittsburgh Picks, Parlay
- Notre Dame Team Total Over 33.5
- Mason Heintschel 250+ Passing Yards
Odds: +170 (DraftKings)
Notre Dame vs Pittsburgh Odds
| Notre Dame Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-12.5 -112 | 54.5 -108o / -112u | -455 |
| Pittsburgh Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+12.5 -108 | 54.5 -108o / -112u | +350 |
Notre Dame Team Total Over 33.5
The Fighting Irish have been elite on offense all season.
While Pitt has been outstanding against the run, this will be the best offensive line the Panthers have faced — along with one of the nation’s top running back duos in Jeremiyah Love and Jadarian Price.
I expect Notre Dame to control the pace throughout and move the ball however it wants in this matchup.
The Irish currently rank seventh nationally in scoring at 38.7 points per game, and their balance should be too much for Pitt to handle.
Mason Heintschel 250+ Passing Yards
The game script should be perfect for this prop.
Pitt is likely to be playing from behind for most of the afternoon, which will force the Panthers to air it out — especially after halftime.
The freshman has cleared this number in four of his five starts, and with Pitt expected to chase points again, he’s well-positioned to do it once more.
Notre Dame vs. Pittsburgh Same-Game Parlay
- Notre Dame Team Total Over 33.5
- Mason Heintschel 250+ Passing Yards
Odds: +170 (DraftKings)
