Syracuse vs. Clemson Odds & Betting Predictions - September 20, 2025

Syracuse at Clemson

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Syracuse Orange

@

Clemson Tigers

MatchupOpenSpreadTotalMoneyline
Syracuse 2-1	+16.5	+17.5-110	o55.5-108	+570
Clemson 1-2	u55.5	-17.5-110	u55.5-112	-850

location pin

Saturday 4:00 p.m.

September 20, 2025

Memorial Stadium (Clemson, SC)Clemson

thermometer image

80°Fahrenheit

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27%Rain

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4Wind

CLEM -17+100

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NCAAF Public Betting

Clemson are 1-2 in their last 5 games.
Clemson are 0-3 in their last 5 games against the spread
Clemson are 0-1 in their road games against the spread
The totals have gone OVER in 0 of Clemson' last 3 games
The totals have gone OVER in 0 of Clemson' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Clemson	0-3	0-2	0-1	0-3	N/A
Syracuse	1-1-1	1-0-1	N/A	0-0-1	0-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Clemson	0-3	0-2	0-1	0-3	N/A
Syracuse	2-1	1-1	N/A	0-1	1-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Clemson	1-2	N/A	N/A	1-2	N/A
Syracuse	2-1	N/A	N/A	1-0	0-1

date	opponent	score	spread	over/under	moneyline
Sep 13th	@GT	L 21-24	-3 L	U 50.5	GT -145
Sep 6th	TROY	W 27-16	-30.5 L	U 51.5	CLEM -11946
Aug 30th	LSU	L 10-17	-5 L	U 55.5	LSU -205
Dec 21st	@TEX	L 24-38	+13.5 L	O 49.5	TEX +470
Dec 8th	@SMU	W 34-31	+2.5 W	O 56.5	CLEM +111

Total

Passing

1138

YDS

633

83/130

Comps/Atts

52/88

8.75

YPA

7.19

9/3

TDs/INTs

3/3

8/56

Sacks/Yards

3/33

Rushing

320

Rush Yards

325

108

Attempts

86

2.96

YPC

3.78

7

TDs

4

Turnovers

Fumbles Lost

3

Interceptions

3

Efficiency

13/16 81.2%

Redzone

6/8 75%

17/39 0%

3rd Down

15/37 0%

4/7 0%

4th Down

3/6 0%

First Downs

80

Total

47

51

Pass

28

25

Rush

15

4

Penalty

4

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Syracuse 2-1	N/A	N/A
Clemson 1-2	N/A	N/A