| Fraser Forster | GK | Out | Back Injury | Back Injury | May 31 |
| Tyler Adams | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Justin Kluivert | F | Out indefinitely | Knock | Knock | Feb 13 |
| Matai Akinmboni | DEF | Out indefinitely | None | Akinmboni is injured | Jan 4 |
| Martin Odegaard | MID | Out indefinitely | Virus | Virus | Jan 24 |
| Christian Norgaard | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Oct 29 |
| Eberechi Eze | F | Doubtful | Eberechi Eze is Doubtful with Physical discomfort. | Eze is doubtful with soreness | Apr 26 |
| Mathias Jensen | MID | Out indefinitely | Knock | Knock | Aug 28 |
| Aaron Hickey | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 23 |
| Michael Kayode | DEF | Out | None | Kayode is out | Jan 25 |
| Joel Veltman | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jan 3 |
| Georginio Rutter | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Jul 11 |
| Kyle Walker | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 6 |
| S. Ojo | A | Out indefinitely | Knock | Knock | Feb 25 |
| G. Madine | A | Out indefinitely | Illness | Illness | Oct 28 |
| Romaine Theodore Sawyers | MID | Out | Suspended | Suspended | Mar 3 |
| J. Philogene | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 7 |
| Wesley Fofana | DEF | Out | Knock | Knock | Apr 4 |
| Mykhailo Mudryk | F | Out | None | Mudryk is out | Sep 2 |
| Borna Sosa | DEF | Out indefinitely | Knock | Knock | Feb 6 |
| Vitaliy Mykolenko | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | May 11 |
| Merlin Rohl | MID | Out | Merlin Röhl is expected to return Late December 2025 from Groin injury. | Rohl is out with groin | Dec 5 |
| Bernd Leno | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Dec 20 |
| Sasa Lukic | MID | Out | Hamstring | Hamstring | Apr 17 |
| Kenny Tete | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 27 |
| Joachim Andersen | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Feb 11 |
| Y. Sanogo | A | Out | Shoulder Injury | Shoulder Injury | Feb 15 |
| M. Lowton | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 26 |
| Jason Puncheon | MID | Out indefinitely | PCL Knee Ligament Injury | PCL Knee Ligament Injury | May 28 |
| Fraizer Campbell | A | Out | Suspended | Suspended | Nov 18 |
| O. Niasse | A | Out | Suspended | Suspended | Nov 29 |
| A. King | MID | Out indefinitely | Hamstring | Hamstring | Aug 14 |
| Joel Castro | GK | Out indefinitely | Back Injury | Back Injury | Nov 21 |
| I. Mbenza | A | Out indefinitely | Knock | Knock | Feb 16 |
| A. Knockaert | MID | Out | Suspended | Suspended | Apr 7 |
| Michael Hefele | DEF | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Aug 9 |
| Tom Smith | DEF | Out | Suspended | Suspended | Mar 9 |
| Jonathan Hogg | MID | Out | Suspended | Suspended | Jan 18 |
| C. Quaner | A | Out | Hamstring | Hamstring | Jan 20 |
| Daniel Williams | MID | Out | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 30 |
| A. Pritchard | MID | Out indefinitely | Foot Injury | Foot Injury | Mar 12 |
| Pipa Ávila | DEF | Out indefinitely | Knock | Knock | Jul 17 |
| K. Ahearne-Grant | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 27 |
| Marc Pugh | MID | Out indefinitely | Hamstring | Hamstring | Sep 24 |
| Curtis Davies | DEF | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| Brian Lenihan | DEF | Out indefinitely | Knee Injury | Knee Injury | Mar 7 |
| Moses Odubajo | DEF | Out | Knee Injury | Knee Injury | Mar 7 |
| Ryan Mason | MID | Out indefinitely | Head Injury | Head Injury | Mar 7 |
| David Meyler | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Jun 8 |
| Sebastian Larsson | MID | Out | Suspended | Suspended | Feb 20 |
| Adama Noss Traoré | MID | Out | Medical Condition | Medical Condition | Feb 29 |
| Evandro Goebel | MID | Out | Groin Strain | Groin Strain | May 31 |
| D. Pelkas | MID | Out indefinitely | Foot Injury | Foot Injury | May 24 |
| O. Tufan | MID | Out indefinitely | Knock | Knock | Feb 18 |
| A. Connolly | A | Out | Chest Injury | Chest Injury | Apr 13 |
| J. Magennis | A | Out | Suspended | Suspended | Nov 24 |
| George Moncur | MID | Out | Suspended | Suspended | Aug 28 |
| Karl Darlow | GK | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 6 |
| Buonanotte Buonanotte | MID | Out | Facundo Buonanotte will not play due to Club decision. | Buonanotte is out with team decision | May 12 |
| Jayden Bogle | DEF | Out | Jayden Bogle is expected to return Late May 2026 from Hamstring Injury. | Bogle is out with hamstring | May 15 |
| Giorgi Mamardashvili | GK | Out | Giorgi Mamardashvili is expected to return Mid May 2026 from Leg injury. | Mamardashvili is out with leg | Apr 21 |
| John Stones | DEF | Out indefinitely | Hamstring | Hamstring | Mar 6 |
| Gianluigi Donnarumma | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 7 |
| Y. Bolasie | A | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| Víctor Valdés Arribas | GK | Out indefinitely | Rib Injury | Rib Injury | May 15 |
| G. Leadbitter | MID | Out | Suspended | Suspended | Mar 10 |
| Paddy McNair | MID | Out | Suspended | Suspended | Dec 29 |
| D. Watmore | MID | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| N. Taylor | DEF | Out | Hamstring | Hamstring | Jul 21 |
| M. Browne | MID | Out | Suspended | Suspended | Dec 29 |
| Z. Steffen | GK | Out indefinitely | Back Injury | Back Injury | Mar 14 |
| M. Johnson | MID | Out | Suspended | Suspended | Dec 7 |
| Kieran Trippier | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 7 |
| Sven Botman | DEF | Out | Sven Botman is expected to return Mid December 2025 from Back injury. | Botman is out with back | Dec 6 |
| B. Gibson | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 15 |
| D. Giannoulis | DEF | Out indefinitely | Back Injury | Back Injury | Sep 19 |
| I. Hayden | MID | Out indefinitely | Knee Injury | Knee Injury | May 19 |
| J. Sørensen | MID | Out | Knee Injury | Knee Injury | Mar 2 |
| S. Vokes | A | Out indefinitely | Abdominal Strain | Abdominal Strain | Nov 4 |
| P. Jagielka | DEF | Out | Suspended | Suspended | Mar 14 |
| Ashley Williams | DEF | Out indefinitely | Rib Injury | Rib Injury | Sep 28 |
| Glen Johnson | DEF | Out indefinitely | Knee Injury | Knee Injury | Feb 1 |
| R. Shawcross | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 22 |
| Charlie Adam | MID | Out | Suspended | Suspended | Apr 16 |
| Stephen Ireland | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 2 |
| M. Diouf | A | Out indefinitely | Dislocated Shoulder | Dislocated Shoulder | Apr 2 |
| J. Ngoy | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Oct 16 |
| D. Gayle | A | Out | Knee Injury | Knee Injury | Dec 12 |
| B. Wilmot | DEF | Out indefinitely | Knee Injury | Knee Injury | Sep 3 |
| K. Hoever | DEF | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Apr 24 |
| Reinildo Mandava | DEF | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Sam Clucas | MID | Out | Suspended | Suspended | Mar 30 |
| Wilfried Guemiand Bony | A | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Jun 11 |
| Kyle Naughton | DEF | Out | Suspended | Suspended | Jan 6 |
| Àngel Rangel Zaragoza | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | May 14 |
| Leon Britton | MID | Out indefinitely | Groin Strain | Groin Strain | Mar 2 |
| Jack Cork | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Nathan Dyer | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Mar 7 |
| Wayne Routledge | MID | Out | Knock | Knock | Dec 27 |
| Oliver McBurnie | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| K. Palmer | MID | Out indefinitely | Hamstring | Hamstring | Nov 20 |
| Cyrus Sylvester Frederick Christie | DEF | Out | Knock | Knock | Feb 9 |
| J. Bidwell | DEF | Out | Suspended | Suspended | Sep 30 |
| J. Piroe | A | Out indefinitely | Virus | Virus | Dec 7 |
| Dejan Kulusevski | MID | Out indefinitely | Hamstring | Hamstring | Nov 10 |
| Mohammed Kudus | MID | Out indefinitely | Knock | Knock | Feb 7 |
| Mathys Tel | F | Out indefinitely | Knock | Knock | Apr 11 |
| D. Gosling | MID | Out | Illness | Illness | Sep 11 |
| Tom Cleverley | MID | Out | Rib Injury | Rib Injury | May 22 |
| B. Hamer | GK | Out indefinitely | Knock | Knock | Jun 10 |
| Heurelho da Silva Gomes | GK | Out | Back Injury | Back Injury | Feb 24 |
| Miguel Ángel Britos Cabrera | DEF | Out indefinitely | Wisdom Teeth | Wisdom Teeth | Jun 5 |
| Craig Cathcart | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 28 |
| J. Holebas | DEF | Out indefinitely | Foot Injury | Foot Injury | Jun 22 |
| Daryl Janmaat | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 15 |
| Christian Kabasele | DEF | Out | Knock | Knock | Jan 1 |
| Younes Kaboul | DEF | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Sep 24 |
| T. Deeney | A | Out indefinitely | Knee Injury | Knee Injury | Nov 8 |
| Ben Foster | GK | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Jan 15 |
| G. Murray | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 27 |
| H. Choudhury | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | May 23 |
| R. Elliot | GK | Out indefinitely | Knock | Knock | Feb 24 |
| O. Etebo | MID | Out indefinitely | Knock | Knock | Jun 30 |
| K. Hause | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| B. Sako | A | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 14 |
| Jake Livermore | MID | Out | Suspended | Suspended | Dec 29 |
| Gareth McAuley | DEF | Out indefinitely | Illness | Illness | Feb 1 |
| James Morrison | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Jun 4 |
| Matt Phillips | MID | Out indefinitely | Virus | Virus | Jan 27 |
| Hal Robson-Kanu | MID | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Jan 18 |
| G. Diangana | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 1 |
| A. Carroll | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 14 |
| K. Bryan | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Dec 30 |
| Matheus Pereira | A | Out | Suspended | Suspended | Dec 27 |
| O. Yokuşlu | MID | Out indefinitely | Hamstring | Hamstring | Jan 3 |
| Kyle Bartley | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Jan 2 |
| K. Zohorè | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Oct 18 |
| Adama Traore | F | Out | Adama Traore is expected to return Late May 2026 from Muscle injury. | Traore is out with muscle | May 15 |
| Alphonse Areola | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| Taty Castellanos | F | Out | Suspended | Suspended | Jan 14 |
| Crysencio Summerville | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Feb 6 |
| Axel Disasi | DEF | Out | Suspended | Suspended | May 1 |
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