| Ander Herrera | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Unai Simon | GK | Doubtful | None | Simon is doubtful | Nov 9 |
| Inaki Williams | F | Out indefinitely | Hamstring | Hamstring | Feb 13 |
| Alex Berenguer | F | Out | Suspended | Suspended | Feb 27 |
| Yuri Berchiche | DEF | Out | Suspended | Suspended | Feb 11 |
| Andoni Gorosabel | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 20 |
| Unai Nunez | DEF | Out | Suspended | Suspended | Feb 12 |
| Oihan Sancet | MID | Doubtful | None | Sancet is doubtful | Nov 9 |
| Cesar Azpilicueta | DEF | Out | Head Injury | Head Injury | Apr 11 |
| Thomas Lemar | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 27 |
| Rodrigo De Paul | MID | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Jose Maria Gimenez | DEF | Out indefinitely | Knock | Knock | Jan 30 |
| Koke | MID | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Marcos Llorente | MID | Out indefinitely | None | Llorente is injured | Nov 9 |
| Reinildo Mandava | DEF | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Alexander Sorloth | F | Out indefinitely | Hamstring | Hamstring | Oct 18 |
| Axel Witsel | MID | Out indefinitely | Knock | Knock | May 2 |
| Javi Galan | MID | Doubtful | None | Galan is doubtful | May 24 |
| Nahuel Molina | DEF | Out | Suspended | Suspended | Sep 3 |
| Pablo Barrios | MID | Out indefinitely | None | Barrios Rivas is injured | Dec 2 |
| Robin Le Normand | DEF | Doubtful | None | Le Normand is doubtful | Nov 9 |
| Robert Lewandowski | F | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Andreas Christensen | DEF | Out indefinitely | None | Christensen is injured | Aug 31 |
| Marc-Andre Ter Stegen | GK | Out indefinitely | Illness | Illness | May 10 |
| Dani Olmo | MID | Out indefinitely | None | Olmo is injured | Sep 15 |
| Raphinha | F | Out | Suspended | Suspended | Apr 1 |
| Ronald Araujo | DEF | Out indefinitely | None | Araujo is injured | Aug 31 |
| Ferran Torres | F | Out indefinitely | None | Torres is injured | Oct 19 |
| Eric Garcia | DEF | Out indefinitely | None | Garcia is injured | Oct 25 |
| Pedri | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Ansu Fati | F | Out indefinitely | Knee Injury | Knee Injury | Mar 6 |
| Javier Ontiveros | F | Out | Shoulder Injury | Shoulder Injury | Apr 27 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Javi Manquillo | DEF | Out indefinitely | None | Manquillo is injured | Jan 22 |
| Jonathan Bamba | F | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jan 31 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Luca De La Torre | MID | Out | Hamstring | Hamstring | Nov 22 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Sergio Carreira | DEF | Out indefinitely | None | Carreira is injured | Nov 3 |
| Jailson | MID | Out indefinitely | None | Jailson is injured | Oct 26 |
| Asier Villalibre | F | Out indefinitely | Hamstring | Hamstring | May 2 |
| Manu Sanchez | MID | Out indefinitely | Hamstring | Hamstring | May 12 |
| Moussa Diarra | DEF | Suspended | None | Diarra is suspended | May 23 |
| Ander Guevara | MID | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Carlos Benavidez | MID | Out indefinitely | None | Benavidez is injured | Nov 8 |
| Pere Milla | MID | Out | Suspended | Suspended | Mar 19 |
| Irvin Cardona | F | Out indefinitely | Foot Injury | Foot Injury | Mar 6 |
| Alex Kral | MID | Out indefinitely | Back Injury | Back Injury | Jan 30 |
| Edu Exposito | MID | Out indefinitely | None | Exposito is injured | Nov 2 |
| Fernando Calero | DEF | Out indefinitely | None | Calero is injured | Nov 2 |
| Pol Lozano | MID | Out indefinitely | None | Lozano is injured | Nov 2 |
| Salvi Sanchez | MID | Out indefinitely | Knock | Knock | Jan 10 |
| Jose Gragera | MID | Out indefinitely | None | Gragera is injured | Nov 2 |
| Alejo Veliz | F | Out indefinitely | None | Veliz is injured | Feb 2 |
| Borja Mayoral | F | Out indefinitely | None | Mayoral is injured | Nov 9 |
| David Soria | GK | Out | Broken Finger | Broken Finger | Sep 4 |
| Djene | DEF | Out indefinitely | None | Djene is injured | Nov 9 |
| Omar Alderete | DEF | Out | Suspended | Suspended | Mar 19 |
| Alex Sola | DEF | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Mubarak Wakaso | MID | Out | Suspended | Suspended | Jan 18 |
| Daley Blind | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 15 |
| Oriol Romeu | MID | Out | Suspended | Suspended | Dec 14 |
| Donny Van De Beek | F | Out indefinitely | Knee Injury | Knee Injury | Feb 25 |
| Yangel Herrera | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Portu | MID | Out indefinitely | None | Portu is injured | Oct 18 |
| Ivan Martin | MID | Out indefinitely | None | Martin is injured | Oct 25 |
| Ricard Artero Ruiz | MID | Out indefinitely | None | Artero Ruiz is injured | Aug 31 |
| Jhon Solis | MID | Out indefinitely | None | Solis is injured | Oct 18 |
| Ladislav Krejci | DEF | Out indefinitely | None | Krejci is injured | Nov 9 |
| Alejandro Frances | DEF | Out indefinitely | None | Frances is injured | Nov 1 |
| Yaser Asprilla | F | Out indefinitely | None | Asprilla is injured | Oct 18 |
| Daley Sinkgraven | DEF | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Enzo Loiodice | MID | Doubtful | None | Loiodice is doubtful | Nov 1 |
| Marvin Park | MID | Out indefinitely | None | Park is injured | Nov 1 |
| Matija Nastasic | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jun 14 |
| Renato Tapia | MID | Out | Suspended | Suspended | Mar 11 |
| Diego Garcia | F | Doubtful | None | Garcia is doubtful | Nov 1 |
| Rúben Vezo | DEF | Out | Suspended | Suspended | Oct 31 |
| Bruno | DEF | Out | Suspended | Suspended | Dec 18 |
| Iborra | MID | Out | Suspended | Suspended | Jan 22 |
| Samuel García Sánchez | MID | Out | Knee Injury | Knee Injury | Jan 8 |
| Wesley Moraes | A | Out indefinitely | Knee Injury | Knee Injury | Apr 25 |
| E. Bardhi | MID | Out indefinitely | Hamstring | Hamstring | Nov 10 |
| Marcelo Josemir Saracchi Pintos | DEF | Out | Suspended | Suspended | Mar 25 |
| Miramón | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Dec 21 |
| Joni Montiel | MID | Out | Suspended | Suspended | Jan 14 |
| N. Vukčević | MID | Out indefinitely | Sprained Ankle | Sprained Ankle | Oct 25 |
| Toño | DEF | Out | Suspended | Suspended | Apr 30 |
| Omar Mascarell | MID | Out | Suspended | Suspended | Feb 15 |
| Sergi Darder | MID | Out | Virus | Virus | Jan 17 |
| Cyle Larin | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 8 |
| Lato Toni | DEF | Out indefinitely | None | Toni is injured | Nov 9 |
| Takuma Asano | F | Out indefinitely | Knee Injury | Knee Injury | Nov 11 |
| Pablo Maffeo | DEF | Out | Suspended | Suspended | Nov 9 |
| Martin Valjent | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Vedat Muriqi | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 28 |
| Antonio Sanchez | MID | Out | Shoulder Injury | Shoulder Injury | Sep 13 |
| Valery Valery | DEF | Out indefinitely | None | Valery is injured | Nov 9 |
| Ivan Cuellar | GK | Out indefinitely | None | Cuellar is injured | Oct 31 |
| M. Peybernes | DEF | Out | Suspended | Suspended | Feb 19 |
| Juanfran | DEF | Out indefinitely | Hamstring | Hamstring | Nov 26 |
| Weligton Róbson Pena de Oliveira | DEF | Out indefinitely | Knee Injury | Knee Injury | Jun 9 |
| Juan Carlos Pérez López | DEF | Out | Suspended | Suspended | Jan 5 |
| Miguel Torres Gómez | DEF | Out | Hamstring | Hamstring | May 24 |
| Sérgio Paulo Barbosa Valente | MID | Out indefinitely | Toe Injury | Toe Injury | May 22 |
| Keko | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 5 |
| Zdravko Kuzmanović | MID | Out indefinitely | Pubalgia | Pubalgia | Jun 12 |
| Jozabed | MID | Out | Suspended | Suspended | Jan 22 |
| Pablo Hervías | MID | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Apr 6 |
| Adrián | A | Out indefinitely | Knock | Knock | Jun 15 |
| Brandon Thomas Llamas | A | Out | Suspended | Suspended | Jan 3 |
| C. Gönen | GK | Out indefinitely | Shoulder Injury | Shoulder Injury | Jun 12 |
| L. Agbenyenu | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jul 17 |
| Joaquín Muñoz | A | Out | Suspended | Suspended | Mar 27 |
| P. Chavarría | A | Out indefinitely | Knock | Knock | Sep 29 |
| E. Burgos | DEF | Out | Suspended | Suspended | Feb 20 |
| M. Benkhemassa | MID | Out | Suspended | Suspended | Jan 26 |
| Caye Quintana | A | Out | Suspended | Suspended | Dec 5 |
| Jonás Ramalho | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Nov 22 |
| Genaro Rodríguez | MID | Out | Suspended | Suspended | Jan 15 |
| Ante Budimir | F | Out indefinitely | Pubalgia | Pubalgia | Oct 25 |
| Lucas Torro | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 23 |
| Sergio Herrera | GK | Out indefinitely | Knee Injury | Knee Injury | Nov 9 |
| Aitor Fernandez | GK | Out | Virus | Virus | May 27 |
| M. Koné | A | Out | Suspended | Suspended | Jan 12 |
| Raúl Carnero | DEF | Out | Suspended | Suspended | Mar 19 |
| Fernando Navarro i Corbacho | DEF | Out | Suspended | Suspended | Apr 1 |
| Rober | DEF | Out indefinitely | Knock | Knock | Nov 29 |
| Ivan Balliu | DEF | Out | Suspended | Suspended | Oct 17 |
| Oscar Trejo | F | Out | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| Alfonso Espino | DEF | Out indefinitely | None | Espino is injured | Sep 15 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Youssouf Sabaly | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Marc Roca | MID | Out indefinitely | None | Roca is injured | Nov 2 |
| Diego Llorente | DEF | Out indefinitely | Knock | Knock | Oct 4 |
| Pablo Fornals | MID | Out indefinitely | None | Fornals is injured | Jan 20 |
| Jimenez Juanmi | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 30 |
| Rui Silva | GK | Out indefinitely | None | Silva is injured | May 24 |
| William Carvalho | MID | Out indefinitely | None | Carvalho is injured | Sep 17 |
| Aitor Ruibal | F | Out indefinitely | None | Ruibal is injured | Nov 2 |
| Chimy Avila | F | Doubtful | None | Avila is doubtful | May 18 |
| Abde Ezzalzouli | F | Out | Suspended | Suspended | Feb 12 |
| Isco | MID | Out indefinitely | None | Isco is injured | Aug 14 |
| Thibaut Courtois | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| David Alaba | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Antonio Rudiger | DEF | Out indefinitely | Hamstring | Hamstring | Dec 7 |
| Dani Ceballos | MID | Out indefinitely | Hamstring | Hamstring | Oct 31 |
| Dani Carvajal | DEF | Out indefinitely | Hamstring | Hamstring | Jan 30 |
| Luka Modric | MID | Doubtful | None | Modric is doubtful | Dec 1 |
| Ferland Mendy | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 11 |
| Andriy Lunin | GK | Out | Virus | Virus | Dec 29 |
| Aurelien Tchouameni | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 2 |
| Jude Bellingham | MID | Out indefinitely | Knock | Knock | Dec 6 |
| Umar Sadiq | F | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Hamari Traore | DEF | Out | Calf Muscle Strain | Calf Muscle Strain | Mar 11 |
| Nayef Aguerd | DEF | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 30 |
| Pablo Marin | MID | Out indefinitely | None | Marin is injured | Oct 18 |
| Benat Turrientes | MID | Out indefinitely | None | Turrientes is injured | Nov 2 |
| Arsen Zakharyan | MID | Out indefinitely | None | Zakharyan is injured | Nov 2 |
| Selim Amallah | MID | Out indefinitely | Hamstring | Hamstring | Apr 4 |
| Y. Muto | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 26 |
| Matheus Pereira | MID | Out | Suspended | Suspended | Oct 30 |
| Etxeita | DEF | Out | Suspended | Suspended | Apr 23 |
| Anaitz Arbilla Zabala | DEF | Out | Suspended | Suspended | Mar 13 |
| Iván Ramis Barrios | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 24 |
| Francisco Manuel Rico Castro | MID | Out indefinitely | Knee Injury | Knee Injury | Jun 30 |
| Imanol Sarriegui Isasa | MID | Out | Hand Injury | Hand Injury | Mar 7 |
| Roberto Antonio Correa Silva | DEF | Out | Suspended | Suspended | Jan 8 |
| Paulo Oliveira | DEF | Out indefinitely | Hamstring | Hamstring | Dec 29 |
| G. Blanco | A | Out | Suspended | Suspended | Jan 10 |
| Javi Muñoz | MID | Out | Suspended | Suspended | Apr 1 |
| Enrique González Casín | A | Out indefinitely | Knock | Knock | Dec 23 |
| Peru Nolaskoain | DEF | Out | Suspended | Suspended | Jan 15 |
| Juan Berrocal | DEF | Out | Suspended | Suspended | Mar 7 |
| S. Okazaki | A | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Mikel Rico | MID | Out indefinitely | Virus | Virus | Nov 9 |
| Pablo Ínsua Blanco | DEF | Out | Suspended | Suspended | Apr 2 |
| Timor | MID | Out indefinitely | Knock | Knock | Dec 20 |
| Luisinho | DEF | Out indefinitely | Knee Injury | Knee Injury | May 22 |
| Juan Pablo Añor Acosta | MID | Out indefinitely | Hamstring | Hamstring | May 1 |
| Juan Pérez | GK | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Dec 20 |
| Cristian Salvador | MID | Out | Suspended | Suspended | Jan 9 |
| Óscar Sielva | MID | Out | Suspended | Suspended | Feb 26 |
| Gerard Valentín | DEF | Out indefinitely | Hamstring | Hamstring | Dec 26 |
| Eugeni Valderrama | MID | Out indefinitely | Hamstring | Hamstring | May 22 |
| K. Nwakali | MID | Out indefinitely | Knock | Knock | Oct 18 |
| Pedro López Muñoz | DEF | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Juan Carlos | | Out | Virus | Virus | Jan 31 |
| Pablo Martínez | MID | Out | Suspended | Suspended | Oct 31 |
| Jesus Navas | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 16 |
| Djibril Sow | MID | Out indefinitely | Knock | Knock | Jun 14 |
| Orjan Nyland | GK | Out indefinitely | Back Injury | Back Injury | Feb 14 |
| Dodi Lukebakio | F | Out indefinitely | Virus | Virus | Jan 17 |
| Suso | F | Out indefinitely | Hamstring | Hamstring | Aug 27 |
| Lucien Agoume | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Jan 19 |
| Chidera Ejuke | F | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Loic Bade | DEF | Out indefinitely | Hamstring | Hamstring | Feb 25 |
| Tanguy Nianzou | DEF | Out indefinitely | None | Nianzou is injured | Nov 2 |
| Stanis Idumbo-Muzambo | MID | Out indefinitely | None | Idumbo-Muzambo is injured | Nov 8 |
| Alejandro Bergantiños García | MID | Out | Suspended | Suspended | Mar 11 |
| Javi Fuego | MID | Out | Suspended | Suspended | Mar 26 |
| Álvaro Vázquez | A | Out | Shoulder Injury | Shoulder Injury | Sep 12 |
| Jony | MID | Out | Suspended | Suspended | Feb 12 |
| Pichu Cuéllar | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Mar 1 |
| J. Babin | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 25 |
| Fernando Amorebieta Mardaras | DEF | Out indefinitely | Knock | Knock | Apr 3 |
| Pedro Díaz Fanjul | MID | Out | Suspended | Suspended | May 10 |
| Juan Rodríguez Martínez | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 1 |
| Sergio Álvarez Díaz | MID | Out | Suspended | Suspended | Feb 12 |
| José Ángel Valdés Díaz | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Aug 24 |
| Jordi Calavera Espinach | DEF | Out indefinitely | Knock | Knock | Apr 22 |
| Pablo Pérez | MID | Out | Suspended | Suspended | May 7 |
| Molinero | DEF | Out | Suspended | Suspended | Jul 6 |
| Marc Valiente | DEF | Out | Suspended | Suspended | Nov 30 |
| J. Otero | A | Out | Suspended | Suspended | Dec 14 |
| Víctor Campuzano | A | Out indefinitely | Back Injury | Back Injury | Mar 1 |
| Vasyl Kravets | DEF | Out | Suspended | Suspended | Jan 23 |
| Fran Villalba | MID | Out | Suspended | Suspended | Apr 2 |
| José Marsà | DEF | Out | Suspended | Suspended | Apr 8 |
| Luis Javier Suarez | F | Out | Suspended | Suspended | Apr 22 |
| Houboulang Mendes | DEF | Out | Knee Injury | Knee Injury | Jan 24 |
| Marko Marezi | F | Out indefinitely | Pubalgia | Pubalgia | Oct 29 |
| Mouctar Diakhaby | DEF | Out indefinitely | None | Diakhaby is injured | Aug 16 |
| Dimitri Foulquier | DEF | Out indefinitely | Hamstring | Hamstring | Jan 20 |
| Rafa Mir | F | Out indefinitely | Knock | Knock | Apr 4 |
| Dani Gomez | F | Out indefinitely | Knock | Knock | Mar 14 |
| Thierry Correia | DEF | Out indefinitely | Hamstring | Hamstring | Feb 27 |
| Maximiliano Caufriez | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 19 |
| Hugo Guillamon | DEF | Out | Suspended | Suspended | Feb 11 |
| Jesus Vazquez | DEF | Doubtful | None | Vazquez is doubtful | Oct 26 |
| Eric Bailly | DEF | Out | Suspended | Suspended | Feb 13 |
| Juan Bernat | DEF | Doubtful | None | Bernat is doubtful | Sep 1 |
| Raul Albiol | DEF | Out indefinitely | Hamstring | Hamstring | Jan 30 |
| Denis Suarez | MID | Doubtful | None | Suarez is doubtful | Nov 8 |
| Gerard Moreno | F | Doubtful | None | Moreno is doubtful | Nov 8 |
| Alfonso Pedraza | F | Out indefinitely | None | Pedraza is injured | Aug 30 |
| Ayoze Perez | F | Out indefinitely | Illness | Illness | Dec 27 |
| Juan Foyth | DEF | Out indefinitely | Knee Injury | Knee Injury | Nov 7 |
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