Cubs vs. Reds Odds & Betting Predictions - September 21, 2025

Cubs at Reds

5:40 pm • MARQ+

Chicago Cubs

0

0 - 1

Cincinnati Reds

1

pitcher		team	era	w-l
A.Abbott			2.87	10-7
J.Taillon			3.68	11-7

MatchupOpenSpreadTotalMoneyline
Cubs 92-70	-1.5	+1.5-198	o9+100	+105
Reds 83-79	u9	-1.5+168	u9-121	-126

location pin

Sunday 5:40 p.m.

September 21, 2025

Great American Ball ParkCincinnati

No props found

MLB Public Betting

Reds are 3-2 in their last 5 games.
Reds are 2-3 in their last 5 games against the spread
Reds are 42-39 in their road games against the spread
The totals have gone OVER in 1 of Reds' last 5 games
The totals have gone OVER in 26 of Reds' 79 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Reds	82-78	40-39	42-39	29-43	53-34
Cubs	78-84	39-42	39-42	55-60	22-24

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Reds	58-91-11	26-45-8	32-46-3	20-47-5	37-44-6
Cubs	74-78-10	40-36-5	34-42-5	52-56-7	22-21-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Reds	83-79	44-35	38-43	39-33	43-44
Cubs	92-70	50-31	42-39	73-42	18-28

date	opponent	score	spread	over/under	moneyline
Sep 20th	CHC	W 6-3	+1.5 W	U 9	CIN -114
Sep 19th	CHC	W 7-4	+1.5 W	O 8	CIN -110
Sep 18th	CHC	W 1-0	-1.5 L	U 8.5	CIN -145
Sep 17th	@STL	W 6-2	-1.5 W	U 8.5	CIN -120
Sep 16th	@STL	L 0-3	-1.5 L	U 8	STL -123

Michael Soroka
SP
Soroka is out with shoulder
Out
Justin Steele
SP
Steele is out for season with elbow
Out for Season

Noelvi Marte
3B
Marte is day-to-day with side
Day-to-Day
Reiver Sanmartin
RP
Sanmartin is out with elbow
Out
Brandon Williamson
SP
Williamson is out for season with elbow
Out for Season
Douglas Ashcraft
RP
Ashcraft is out with groin
Out
Chase Burns
SP
Burns is out with hip
Out
Julian Aguiar
SP
Aguiar is out for season with elbow
Out for Season
Rhett Lowder
SP
Lowder is out with elbow
Out
William Spiers
RP
Spiers is out with shoulder
Out

See more MLB Injuries

PITCHER		PC	IP	K	ER
RJ.Taillon, P		82	7	4	1
RB.Keller, P		11	1	1	0

HITTERS	H-AB	R	HR	RBI
1N.Hoerner, 2B	0-4	0	0	0
2I.Happ, LF	1-4	0	0	0
3S.Suzuki, RF	1-4	0	0	0
4C.Kelly, C	0-3	0	0	0
5C.Santana, DH	1-2	0	0	0
5M.Ballesteros, PH	0-1	0	0	0
5M.Ballesteros, DH	0-1	0	0	0
6D.Swanson, SS	1-4	0	0	0
7J.Turner, 3B	0-3	0	0	0
7W.Castro, PH	0-1	0	0	0
8M.Busch, 1B	1-3	0	0	0
9K.Alcantara, CF	1-2	0	0	0
9P.Crow-Armstrong, PH	0-2	0	0	0
9P.Crow-Armstrong, CF	0-2	0	0	0

PITCHER		PC	IP	K	ER
LA.Abbott, P		86	4.2	2	0
RN.Martinez, P		34	2.1	1	0
RG.Ashcraft, P		17	1	1	0
RT.Santillan, P		23	1	2	0

HITTERS	H-AB	R	HR	RBI
1T.Friedl, CF	0-4	0	0	0
2G.Lux, DH	2-4	0	0	1
3N.Marte, RF	1-3	0	0	0
4S.Steer, 1B	0-3	0	0	0
5W.Benson, LF	0-3	0	0	0
6E.De La Cruz, SS	1-3	0	0	0
7K.Hayes, 3B	0-3	0	0	0
8J.Trevino, C	0-3	0	0	0
9M.McLain, 2B	1-3	1	0	0

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MatchupOverUnder
Cubs 92-70	o4.5+109	u4.5-140
Reds 83-79	o4.5+104	u4.5-133