Twins vs. Guardians Odds & Betting Predictions - July 21, 2026

Twins at Guardians

10:40 pm • MNNT
@
Starting Pitchers
pitcherteameraw-l
Parker Messick logoP.MessickCleveland Guardians logo2.738-5
Kendry Rojas logoK.RojasMinnesota Twins logo2.791-1

Twins at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
49-52
+1.5
+1.5-170
o8-115
+125
Guardians
53-48
u8.5
-1.5+140
u8-105
-150
location pinTuesday 10:40 p.m.
July 21, 2026
Progressive FieldCleveland
thermometer image79°Fahrenheit
rain image43%Rain
wind image13Wind
Twins vs. Guardians Expert Picks
OldSchool0909
Last 30d: 30-34-0 (+2.9u)
MIN +130
1u
Adam Kaufman
Adam Kaufman
Last 30d: 120-107-3 (+7.7u)
CLE -148
1.48u
Frank Ammirante
Frank Ammirante
Last 30d: 328-376-7 (-41.4u)
CLE -152
1.52u
P.Messick o4.5 Ks-164
1.64u

Twins vs. Guardians Previews & Analysis

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    Sharp Steam Moves Piling Up (2 Picks)

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    Jul 21, 2026 UTC
  • Twins vs Guardians: Strikeout Arms Take the Stage article feature image

    Twins vs Guardians: Strikeout Arms Take the Stage

    Action Network Staff
    Jul 21, 2026 UTC
  • Grant Neiffer: Home Run Picks for Nine Games on Dinger Tuesday article feature image

    Grant Neiffer: Home Run Picks for Nine Games on Dinger Tuesday

    Grant Neiffer
    Jul 21, 2026 UTC
  • Opening Pitch: Zerillo's MLB Projection for Tuesday article feature image

    Opening Pitch: Zerillo's MLB Projection for Tuesday

    Sean Zerillo
    Jul 21, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Guardians Public Betting Percentages

Away Logo

Twins

Public

16%

Bets%

84%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
52-4925-2527-2423-3129-15
Twins
52-4926-2526-2413-1938-29

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
48-5326-2422-2928-2619-25
Twins
56-39-624-23-432-16-217-14-138-24-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
53-4826-2427-2429-2524-20
Twins
49-5226-2523-2717-1531-36

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 20thMINW 13-4+1.5 WO 7.5CLE +111
Jul 19thPITL 1-7+1.5 LO 7PIT -116
Jul 18thPITW 5-3+1.5 WU 8.5CLE -110
Jul 18thPITL 1-7-1.5 LO 7.5PIT -131
Jul 12th@MIAW 5-2-1.5 WU 7.5CLE -114

Guardians vs. Twins Injury Updates

Guardians Injuries

    Twins Injuries

    • Pablo Lopez
      SP

      Lopez is out with elbow

      Out

    • David Festa
      SP

      Festa is out with shoulder

      Out

    • Travis Adams
      SP

      Adams is out with triceps

      Out

    Twins vs. Guardians Starting Lineups
    Twins Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Kendry Rojas logoLK.Rojas, P1-12.791.60310.24
    HITTERSAVGOBPSLGHR
    Austin Martin logo1A.Martin, LF.244.357.3192
    Byron Buxton logo2B.Buxton, CF.275.331.57625
    Ryan Jeffers logo3R.Jeffers, C.288.401.5408
    Josh Bell logo4J.Bell, DH.251.309.42713
    Royce Lewis logo5R.Lewis, 2B.218.295.39510
    Victor Caratini logo6V.Caratini, 1B.240.330.3697
    Luke Keaschall logo7L.Keaschall, RF.263.352.3524
    Brooks Lee logo8B.Lee, 3B.252.309.42914
    Ryan Kreidler logo9R.Kreidler, SS.246.310.4085
    Guardians Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Parker Messick logoLP.Messick, P8-52.731.0718.84
    HITTERSAVGOBPSLGHR
    Steven Kwan logo1S.Kwan, LF.238.343.2961
    Travis Bazzana logo2T.Bazzana, 2B.246.337.4199
    Chase DeLauter logo3C.DeLauter, DH.286.351.45711
    Brayan Rocchio logo4B.Rocchio, SS.271.335.4059
    Kyle Manzardo logo5K.Manzardo, 1B.211.303.35410
    Kahlil Watson logo6K.Watson, RF.233.258.3261
    Gabriel Arias logo7G.Arias, 3B.232.276.4045
    Patrick Bailey logo8P.Bailey, C.239.276.3853
    Petey Halpin logo9P.Halpin, CF.222.243.3752

    Twins vs. Guardians Odds Comparison

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    Twins at Guardians Team Totals

    MatchupOverUnder
    Twins
    49-52
    N/A
    N/A
    Guardians
    53-48
    N/A
    N/A