The Houston Astros (4-2) host the Boston Red Sox (1-4) on April 1, 2026. First pitch from Daikin Park is scheduled for 2:10 p.m. EDT. The game will be broadcast on NESN.
The Red Sox are favored by -146 on the moneyline and by -1.5 (+125) on the run line. The Astros are +124 on the moneyline and +1.5 (-150) on the run line. The total is set at 7 runs (-110 / -110).
Find my MLB picks and Red Sox vs Astros prediction below, as well as probable pitchers, weather report, and more.
Red Sox vs Astros Predictions, Pick
- Red Sox vs Astros Pick: Red Sox ML (-150 or Better) | Red Sox F5 ML (-165 or Better)
My Red Sox vs Astros best bet is on Boston to win both halves. Make sure to find the best odds by checking our live MLB odds page.
Red Sox vs Astros Odds, Spread, Line
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +125 | 7 -110o / -110u | -146 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -150 | 7 -110o / -110u | +124 |
- Red Sox vs Astros spread: Red Sox -1.5 (+125), Astros +1.5 (-150)
- Red Sox vs Astros over/under: 7 (-110 / -110)
- Red Sox vs Astros moneyline: Red Sox -146, Astros +124
Red Sox vs Astros MLB Betting Preview
Red Sox vs Astros Pick, Betting Analysis
The Red Sox played their backup catcher, Connor Wong (who projects as one of my worst defensive catchers), on Tuesday, which partially moved my projection and drove me to bet the Astros F5 moneyline behind Hunter Brown.
I'm on the other side of the moneyline for Wednesday, with Carlos Narvaez back behind the dish for Boston, and Garrett Crochet trying to halt their four-game losing streak following his dominant opening day effort (6 IP, 3 H, 2 BB, 8 K in a shutout win) in Cincinnati.
Mike Burrows (projected FIP range of 4.18 to 4.45; projected K-BB% of 14.2% to 16%) is an above-average starting pitcher, but Crochet (projected FIP range of 2.83 to 3.04; projected K-BB rate of 23.8% to 24.2%) is in an elite tier with the likes of Paul Skenes (2.76 weighted FIP) and Tarik Skubal (2.61), and he's even a half tier ahead of a pitcher like Yoshinobu Yamamoto (3.22) — all of whom are starting on Wednesday.
Houston's offense actually projects better against lefties than righties by about three points in wRC+, but I still show an edge on Crochet and the Red Sox in both halves.
Pick: Red Sox ML (-150 or Better) | Red Sox F5 ML (-165 or Better)
