The St. Louis Cardinals host the Cincinnati Reds on June 6, 2026. First pitch from Busch Stadium is scheduled for 2:15 p.m. EDT. The game will be broadcast on CINR.
The Cardinals are favored by -126 on the moneyline and by -1.5 on the run line. The Reds are +108 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Reds vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Reds vs Cardinals Prediction
- Reds vs Cardinals Pick: Cardinals ML (-135 or Better)
My Reds vs Cardinals best bet is on St. Louis. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cardinals Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -194 | 9.5 -104o / -118u | +108 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +160 | 9.5 -104o / -118u | -126 |
- Reds vs Cardinals moneyline: Reds +108, Cardinals -126
- Reds vs Cardinals over/under: 9.5 (-104 / -118)
- Reds vs Cardinals spread: Cardinals -1.5 (+160), Reds +1.5 (-194)
Reds vs Cardinals Probable Pitchers
| Nick Lodolo (LHP, CIN) | Stat | Matthew Liberatore (LHP, STL) |
|---|---|---|
| 2-1 | W-L | 3-3 |
| -0.3 | fWAR (FanGraphs) | 0.4 |
| 5.20 / 6.64 | ERA / xERA | 4.35 / 5.25 |
| 6.76 / 5.13 | FIP / xFIP | 4.48 / 3.98 |
| 7.5% | K-BB% | 12.7% |
| 39.2% | GB% | 38.5% |
| .247 | BABIP | .337 |
| 107 | Stuff+ | 99 |
| 88 | Location+ | 101 |
Reds vs Cardinals MLB Betting Preview
I remember hearing some broadcast or another talk about how Matthew Liberatore was finally turning into the pitcher the Cardinals had always hoped he would be.
I currently value him almost a quarter run below his 4.35 ERA because he has been pitching well over the last month (21.8% K-BB).
While Nick Lodolo allowed nine of his 16 runs this season in his first two starts, he’s also failed to strike out more batters than he’s walked in two of three since.
Things are not going well for him, and his 5.20 ERA fits the underlying performance. It’s just five starts, but even dropping his projections closer to 4 1/2 doesn’t change my conclusion for this game.
The fact is, the Cardinals seem to have every advantage.
Offensively, their projected lineup has a 38-point wRC+ edge over the last 30 days and a 23-point edge against southpaws since last season.
Defensively, those same projected lineups would give St. Louis a seven FRV gap plus another seven base running runs.
Finally, they are at home, and their bullpen has been more than a full run better than the Reds over the last month, in which Cincinnati has been a bottom-three relief corps with a league-worst 5.71 FIP.
Reds vs Cardinals Pick, Betting Analysis
Not all of these advantages are significant, but combined, they are enough to find value in a lightly favored Cardinal team.
Despite the large bullpen gap, I have F5 and the full game price valued evenly. It’s just a matter of preference and whether you favor the potential of a push.
Pick: Cardinals ML (-135 or Better)
