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Guardians vs Reds Game 2 Prediction, Pick, MLB Odds for Tuesday, July 28

Guardians vs Reds Game 2 Prediction, Pick, MLB Odds for Tuesday, July 28 article feature image
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Bruce Kluckhohn-Imagn Images. Pictured: Guardians SP Gavin Williams

The Cincinnati Reds host the Cleveland Guardians in the second part of a doubleheader on July 28, 2026. First pitch from Great American Ball Park is scheduled for 7:10 p.m. ET. The game will be broadcast on CINR.

The Guardians are favored by -130 on the moneyline and by -1.5 on the run line. The Reds are +110 on the moneyline and +1.5 on the run line. The total is set at 9 runs.

Find my MLB picks and Guardians vs Reds prediction below, as well as probable pitchers, weather report, and more.


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Guardians vs Reds Prediction

  • Guardians vs Reds Pick: Under 9 (-110)

My Guardians vs Reds best bet is Under 9 total runs in this second game. Make sure to find the best odds by checking our live MLB odds page.


Guardians vs Reds Odds

Guardians Logo
Tuesday, Jul 28
7:10 p.m. ET
CINR
Reds Logo
Guardians Odds
SpreadTotalMoneyline
-1.5
+126
9
-110o / -110u
-130
Reds Odds
SpreadTotalMoneyline
+1.5
-152
9
-110o / -110u
+110
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Guardians vs Reds moneyline: Guardians -130, Reds +110
  • Guardians vs Reds over/under: 9 (-110o / -110u)
  • Guardians vs Reds spread: Guardians -1.5 (+126), Reds +1.5 (-152)

Guardians vs Reds Probable Pitchers

Gavin Williams (RHP, CLE)StatJose Franco (RHP, CIN)
10-5W-L0-0
2.3fWAR (FanGraphs)-0.2
3.78 / 4.12ERA / xERA5.40 / 5.44
3.65 / 2.99FIP / xFIP6.41 / 6.28
23.4K-BB%-1.3
45.6GB%32.7
.281BABIP.306
105Stuff+95
105Location+90

Guardians vs Reds MLB Betting Preview

Editor's Note: This written pick is a transcription from today's episode of the Payoff Pitch Podcast.

This should be a bullpen game. Brady Singer is on the trade block, and he was originally slated to start today for the Reds. They're not really saying what they're doing with him. So I don't know if they have potentially a deal in place for Singer that they're waiting on and don't want him to get hurt.

He was initially supposed to start before the doubleheader was announced. Now he's not. That leads me to believe that there's a trade in place for him, and we may see him dealt in the next couple of days.

Regarding tonight, we're expecting a bullpen game for the Reds, including some combination of Tejay Antone and Chase Petty for about four innings of the nine. We'll see what bullpen the Reds have left after Game 1, which Chase Burns starts against the Guardians.

I have done some research into doubleheaders, specifically by running back through our Action Labs database and seeing how they perform relative to the market and expectations.

Game 1 typically goes over by about 3/10 of a run per game. Game 2 plays a little bit more normally. And I think it's because Game 1, once one team gets out to a multi-run lead, the losing team just starts throwing out the bad bullpen in an effort to save their leverage relievers for Game 2.

So I would be really careful betting Game 1 unders in doubleheaders, as you may not get the pitchers that you're anticipating into that mix. Meanwhile, for Game 2, you kind of know who's available and who's not.


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Guardians vs Reds Pick, Betting Analysis

I make this total closer to 8.3 total runs, and I like the under 9 down to -120.

However, if the Reds bullpen gets wiped out in Game 1, we have the option to just buy out of this bet with no harm, no foul.

But going into Game 1, I think there is value on the Game 2 under, and I'd be willing to lock it in up to -120 on the Under 9.

Pick: Under 9 (-110, FanDuel)


Guardians vs Reds Weather


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About the Author

Sean graduated from the University of Miami and Hofstra University Law School, later passing the New York State Bar Exam in 2014. He shifted from a legal career to sports data and betting, joining the Action Network in 2019 after working as a baseball video scout and in financial regulatory compliance. As a senior writer and betting analyst, Sean provides MLB and MMA projections using proprietary models and contributes to various digital content and podcasts, becoming a leading expert in betting for baseball, MMA, and horse racing.

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