The Detroit Tigers host the Cleveland Guardians on Wednesday, May 20. First pitch from Comerica Park is scheduled for 6:40 p.m. ET. The game will be broadcast on DSN and MLB.TV.
The Guardians are favored by -126 on the moneyline and by -1.5 on the run line. The Tigers are +105 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find our MLB picks and Guardians vs Tigers prediction below, as well as probable pitchers, weather report, and more.
Cleveland Guardians vs Detroit Tigers Prediction, Picks
- Guardians vs Tigers Pick: Colt Keith Over 0.5 Singles (+135)
Our Guardians vs Tigers best bet is Colt Keith to hit one or more singles in this game. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs Tigers Odds, Spread, Line
| Guardians Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +146 | 7.5 -100o / -122u | -122 |
| Tigers Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -176 | 7.5 -100o / -122u | +104 |
- Guardians vs Tigers Moneyline: Guardians ML -122, Tigers ML +104
- Guardians vs Tigers Over/Under: 7.5
- Guardians vs Tigers Run Line: Guardians -1.5 (+146), Tigers +1.5 (-176)
Guardians vs Tigers Starting Pitchers
| RHP Tanner Bibee (CLE) | Stat | RHP Drew Anderson (DET) |
|---|---|---|
| 0-6 | W-L | 1-1 |
| 0.7 | fWAR (FanGraphs) | 0.2 |
| 4.15 / 3.75 | ERA / xERA | 4.67 / 3.51 |
| 4.27 / 4.17 | FIP / xFIP | 3.71 / 3.41 |
| 12.2 | K-BB% | 16.4 |
| 40.5 | GB% | 52.1 |
| .293 | BABIP | .304 |
| 104 | Stuff+ | 98 |
| 98 | Location+ | 100 |
Guardians vs Tigers Preview
Action PRO projects Tigers DH Colt Keith for 0.71 singles today against the Guardians, giving us a solid 8.3% edge against the market when compared to his current prop line of over/under 0.5, which is good enough to mark the over with a B- grade in our system.
Keith is hitting .291 this season, but he's not really an extra-base guy. He only has 8 doubles, with no triples or homers so far.
This explains his .351 slugging and .682 OPS despite doing so well at the plate. Of his 39 hits, 31 have been singles.
Today, he will face Guardians starter Tanner Bibee, who's been abysmal in away games in 2026. The righty has an 8.15 ERA and a .324 opponent batting average on the road.
Guardians vs Tigers MLB Pick, Best Bet
Keith has surpassed this line in four of his last eight games, but his chances look much better at home against Bibee.
Keith has really favorable splits for this game. He's hitting .304 against right-handed pitchers and .309 at Comerica Park.
At plus money, let's back him to get another single against Cleveland.
Pick: Colt Keith Over 0.5 Singles (+135)
