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Home Run Picks Today: MLB Player Prop Best Bets for Cubs vs White Sox, Giants vs Athletics for Saturday, May 16

Home Run Picks Today: MLB Player Prop Best Bets for Cubs vs White Sox, Giants vs Athletics for Saturday, May 16 article feature image
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May 7, 2026; Philadelphia, Pennsylvania, USA; Athletics right fielder Brent Rooker (25) hits a two RBI home run against the Philadelphia Phillies during the first inning at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

Happy Saturday!

We've made it to the weekend, so I've got some bangers.

Read on for my 2 favorite home run picks today, including predictions for Cubs vs White Sox and Giants vs Athletics on Saturday, May 16.


Home Run Picks Today

GameTime (ET)Pick
Chicago Cubs LogoChicago White Sox Logo
7:10 PM
San Francisco Giants LogoOakland Athletics Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Cubs vs White Sox Prediction

Chicago Cubs Logo
Saturday, May 16
7:10 PM ET
MLB.TV
Chicago White Sox Logo
Seiya Suzuki Home Run
FanDuel Logo

After a slow start to the season, Seiya Suzuki has been great in the last month, hitting seven bombs.

He gets a matchup against Davis Martin, who has been great this season. However, he is due for some heavy regression and grades out as a slightly below-average matchup for righty power.

I make the fair odds on this home run prop around +450.

Pick: Seiya Suzuki Home Run


Giants vs Athletics Prediction

San Francisco Giants Logo
Saturday, May 16
9:40 PM ET
MLB.TV
Oakland Athletics Logo
Brent Rooker Home Run
FanDuel Logo

Brent Rooker has been up and down this season, but he's still one of the best HR hitters in the league.

The matchup against Trevor McDonald today is below average for power, but the ballpark is one of the best in the majors for power, and the weather is good for hitting, with temps in the low 80s.

I make the fair odds on this home run prop around +350.

Pick: Brent Rooker Home Run

Author Profile
About the Author
Grant NeifferVerified Action Expert

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