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MLB Home Run Picks, Predictions: 3 HR Best Bets for Yankees vs Rangers, Angels vs White Sox, More on April 27

MLB Home Run Picks, Predictions: 3 HR Best Bets for Yankees vs Rangers, Angels vs White Sox, More on April 27 article feature image
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Ed Szczepanski-Imagn Images

Pictured: Munetaka Murakami

I'm on three home run props for the eight-game MLB slate on Monday, April 27, targeting the following games: Rays vs Guardians, Angels vs White Sox, and Yankees vs Rangers.

Read on for my Home Run Picks and find out why I'm on Junior Caminero, Munetaka Murakami, and Trent Grisham tonight.


MLB Home Run Picks, Predictions

In the table below, you'll find each of Grant Neiffer's top home run prop picks from today's slate of games. Click on any pick or team logo to navigate to a specific bet discussed in this article.

Time (ET)Player Prop
6:10 p.m.
7:40 p.m.
8:05 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.
Playbook

Rays vs. Guardians Home Run Pick

Tampa Bay Rays Logo
Monday, April 27
6:10 p.m. ET
MLB.TV
Cleveland Guardians Logo
Header First Logo

Junior Caminero

Over 0.5 HRs (+395)

Header Trailing Logo

Caminero has been fantastic to start the season and is one of the best HR hitters in the league.

This ballpark is decent, and the weather should be great for hitting, with temps in the low-70s and wind blowing out to left field at 12 mph.

Opposing pitcher Parker Messick has been great to start the season, but he's due for some heavy regression and grades out around an average matchup for righty power.

I have the true odds here around +350, making this a great bet.

Pick: Junior Caminero Over 0.5 HRs (+395)


Angels vs. White Sox Homer Prop

Los Angeles Angels Logo
Monday, April 27
7:40 p.m. ET
MLB.TV
Chicago White Sox Logo
Header First Logo

Munetaka Murakami

Over 0.5 HRs (+329)

Header Trailing Logo

Murakami has been incredible this season, and he gets a great spot tonight. Jack Kochanowicz has been a gas can for lefty power in his career, giving up a high 1.43 HR/9.

The weather is going to be a concern, but I think this game will play clean, and it's only an average downgrade to power.

I have the true odds here around +280, making this a great bet.

Pick: Munetaka Murakami Over 0.5 HRs (+329)


Yankees vs. Rangers HR Pick

New York Yankees Logo
Monday, April 27
8:05 p.m. ET
MLB.TV
Texas Rangers Logo
Header First Logo

Trent Grisham

Over 0.5 HRs (+440)

Header Trailing Logo

Grisham isn't off to a great start this season after his breakout 2025 season, but he's due for some positive regression and is an above-average power hitter.

He gets a good matchup vs. Jack Leiter, who has allowed a career 1.23 HR/9 to lefties and grades out as an above-average matchup for lefty power.

I have the true odds here under +400, making this a great bet.

Pick: Trent Grisham Over 0.5 HRs (+440)


Author Profile
About the Author
Grant NeifferVerified Action Expert

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