| E. Hyndman | MID | Out indefinitely | Broken Leg | Broken Leg | Aug 27 |
| A. Kann | GK | Out indefinitely | None | Kann is injured | Jul 20 |
| R. Hernández | DEF | Out indefinitely | None | Hernandez is injured | Sep 14 |
| E. Rigoni | A | Out | Hamstring | Hamstring | Mar 17 |
| Bojan | A | Out indefinitely | Hamstring | Hamstring | Oct 16 |
| V. Wanyama | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 29 |
| E. Bush | GK | Out indefinitely | None | Bush is injured | Aug 31 |
| Maximiliano Urruti | A | Doubtful | None | Urruti is doubtful | Oct 6 |
| Doneil Henry | DEF | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Feb 25 |
| C. Fuchs | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Sep 14 |
| Patrick Agyemang | forward | Doubtful | None | Agyemang is doubtful | Sep 18 |
| Bastian Schweinsteiger | MID | Out indefinitely | Knock | Knock | Oct 13 |
| R. Berič | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 2 |
| N. Gaitán | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Sep 11 |
| Álvaro Medrán Just | MID | Out indefinitely | Back Injury | Back Injury | May 3 |
| L. Abubakar | DEF | Out indefinitely | None | Abubakar is injured | Sep 18 |
| S. Nicholson | MID | Out indefinitely | None | Nicholson is injured | Oct 21 |
| Juan Camilo Hernández Suárez | A | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| B. Smith | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Jan 12 |
| C. Benteke | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| W. Rooney | A | Out indefinitely | Knee Injury | Knee Injury | May 28 |
| B. Hines-Ike | DEF | Suspended | None | Hines-Ike is suspended | Sep 18 |
| J. Hopkins | MID | Out indefinitely | None | Hopkins is injured | Aug 24 |
| G. Cameron | DEF | Out | Concussion | Concussion | Dec 1 |
| M. Deplagne | DEF | Out indefinitely | Knock | Knock | Jun 4 |
| S. de Jong | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| C. Stanko | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 16 |
| Matt Hedges | DEF | Out indefinitely | None | Hedges is injured | Sep 18 |
| Paxton Pomykal | MID | Out indefinitely | None | Pomykal is injured | May 24 |
| E. Cerrillo | MID | Suspended | None | Cerrillo is suspended | Sep 18 |
| F. Quignón | MID | Doubtful | None | Quignon is doubtful | Nov 10 |
| N. Quiñónes | A | Out indefinitely | None | Quinones is injured | Jun 18 |
| K. Gibbs | DEF | Out | Back Injury | Back Injury | Feb 27 |
| Blaise Matuidi | MID | Out indefinitely | Groin Strain | Groin Strain | Mar 20 |
| Kelvin Walther Gianini Leerdam | DEF | Out indefinitely | Knee Injury | Knee Injury | May 1 |
| C. Dos Santos | GK | Out indefinitely | None | Dos Santos is injured | Aug 31 |
| Douglas Costa | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Feb 10 |
| R. Alessandrini | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 6 |
| N. DePuy | DEF | Out indefinitely | None | DePuy is injured | Sep 23 |
| K. Cabral | A | Out indefinitely | None | Cabral is injured | Jul 20 |
| Tello | A | Out indefinitely | Knock | Knock | Apr 4 |
| D. Bouanga | A | Out | Suspended | Suspended | Jan 4 |
| C. Arango | A | Suspended | None | Arango is suspended | Sep 18 |
| K. Vermeer | GK | Out indefinitely | Knock | Knock | Dec 16 |
| J. Murillo | DEF | Out indefinitely | None | Murillo is injured | Sep 14 |
| Z. Valentin | DEF | Out indefinitely | None | Valentin is injured | Sep 14 |
| Vadim Demidov | DEF | Out indefinitely | Hamstring | Hamstring | Mar 9 |
| Randall Enrique Leal Arley | MID | Out indefinitely | None | Leal is injured | Jun 18 |
| J. Shaffelburg | A | Doubtful | None | Shaffelburg is doubtful | Sep 14 |
| Brou Benjamin Angoua | DEF | Out indefinitely | Knock | Knock | Mar 19 |
| Wilfrid Jaures Kaptoum | MID | Out indefinitely | Hamstring | Hamstring | Oct 27 |
| Damian Rivera | midfielder | Out indefinitely | None | Rivera is injured | Sep 30 |
| M. Stajduhar | GK | Out indefinitely | None | Stajduhar is injured | Jul 4 |
| Andre Blake | GK | Doubtful | None | Blake is doubtful | Sep 18 |
| C. Bravo | DEF | Doubtful | None | Bravo is doubtful | Sep 18 |
| Bobby Shou Wood | A | Out indefinitely | Knee Injury | Knee Injury | Jun 10 |
| Stephen Obayan Sunday | MID | Out indefinitely | Suspended | Suspended | Feb 24 |
| P. Ruíz | MID | Out indefinitely | None | Ruiz is injured | Jul 6 |
| James Marcinkowski | GK | Out indefinitely | None | Marcinkowski is injured | May 31 |
| M. López | DEF | Out indefinitely | Knock | Knock | Aug 28 |
| J. Skahan | MID | Suspended | None | Skahan is suspended | Sep 18 |
| B. Kikanovic | A | Out indefinitely | None | Kikanovic is injured | Sep 18 |
| Michael Robert Baldisimo | MID | Out indefinitely | None | Baldisimo is injured | Sep 14 |
| Víctor Rodríguez Romero | MID | Out indefinitely | Knock | Knock | Feb 28 |
| João Paulo | MID | Out indefinitely | None | Paulo is injured | Sep 7 |
| R. Walter | MID | Out | Ankle Ligaments | Ankle Ligaments | Oct 14 |
| N. Radoja | MID | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| N. Isimat-Mirin | DEF | Out | Knee Injury | Knee Injury | Feb 15 |
| C. Salcedo | DEF | Out | Foot Injury | Foot Injury | Nov 29 |
| N. Hagglund | DEF | Out indefinitely | None | Hagglund is injured | Aug 24 |
| Q. Westberg | GK | Out indefinitely | None | Westberg is injured | Aug 24 |
| L. MacNaughton | DEF | Out indefinitely | None | MacNaughton is injured | Jun 18 |
| Russell Teibert | MID | Out indefinitely | None | Teibert is injured | Nov 4 |
| A. Cubas | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 4 |
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