Louisville vs. Cincinnati Odds & Betting Predictions - November 21, 2025

Louisville at Cincinnati

11:30 pm • ESPN2

Louisville Cardinals

7-1

74 - 64

Cincinnati Bearcats

6-3

MatchupOpenSpreadTotalMoneyline
Louisville 7-1	N/A	N/A	N/A
Cincinnati 6-3	N/A	u163.5-115	N/A

Friday 11:30 p.m.

November 21, 2025

Fifth Third ArenaCincinnati

LOU -125 (Live)

0.8u

CIN +5.5 (1H)-110

1.82u

Under 164.5-115

0.87u

LOU -8.5-111

CIN +8.5-110

Article up

Back This Undervalued Team & More NCAAB Saturday Best Bets
Action Network Staff•
Nov 22, 2025 UTC
Louisville vs Cincinnati: Lace 'Em Up!
Sean Paul•
Nov 21, 2025 UTC

See more NCAAB Coverage

No props found

NCAAB Public Betting

Cincinnati are 2-3 in their last 5 games.
Cincinnati are 0-5 in their last 5 games against the spread
Cincinnati are 0-1 in their road games against the spread
The totals have gone OVER in 2 of Cincinnati' last 5 games
The totals have gone OVER in 2 of Cincinnati' 8 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cincinnati	2-7	2-6	0-1	2-4	0-2
Louisville	5-3	4-2	1-1	2-1	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cincinnati	3-6	2-6	1-0	1-5	1-1
Louisville	4-4	3-3	1-1	2-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cincinnati	6-3	N/A	N/A	5-1	0-2
Louisville	7-1	N/A	N/A	2-1	N/A

date	opponent	score	spread	over/under	moneyline
Nov 16th	MSM	W 72-55	-	-	-
Nov 12th	DAY	W 74-62	-6.5 W	U 148.5	CIN -276
Nov 8th	GAST	W 74-64	-29.5 L	U 150.5	CIN -20000
Nov 4th	WCU	W 94-63	-22.5 W	O 144.5	-
Apr 3rd	UCF	L 80-88	-7 L	O 157.5	UCF -302

Louisville

Cincinnati

21-56 (38%)

Field Goals

23-62 (37%)

24-28 (86%)

Free Throws

10-16 (63%)

8-28 (29%)

8-29 (28%)

Rebounds

Assists

Turnovers

Steals

Blocks

Fouls

Could not load odds

See more NCAAB Odds

MatchupOverUnder
Louisville 7-1	N/A	u87.5-115
Cincinnati 6-3	o77.5-110	u77.5-120

Louisville vs. Cincinnati Odds & Betting Predictions - November 21, 2025

Louisville at Cincinnati

Louisville Cardinals

Cincinnati Bearcats

Louisville at Cincinnati Odds

Spread, Total, Moneyline

Louisville vs. Cincinnati Previews & Analysis

Back This Undervalued Team & More NCAAB Saturday Best Bets

Louisville vs Cincinnati: Lace 'Em Up!

Prop Odds Comparison

Line Movement Tracker

Louisville vs. Cincinnati Public Betting Percentages

Louisville

Public

Cincinnati

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Louisville vs. Cincinnati Odds Comparison

Louisville at Cincinnati Team Totals