Why is nobody talking about the Clemson Tigers (6-1, 5-0 ACC)? They got crushed by Georgia in the season opener, which is understandable, and everybody wrote them off.
Since then, Clemson has boat-raced every team it has played, The Tigers have reeled off six-straight wins and have outscored their opponents 291-127. They are crushing teams and appear on a crash course for the ACC Championship game.
The Louisville Cardinals (5-2, 3-2) entered the season with expectations of returning to the conference title game for the second year in a row, but instead, have dropped three of their last five games and will likely find themselves on the outside looking in.
Where does the betting value lie? Read more for my Louisville vs Clemson predictions and college football picks for Saturday, Nov. 2.
Louisville Cardinals vs Clemson Tigers Prediction
- Louisville vs. Clemson Pick: Clemson -10
My Clemson vs Louisville best bet is on the Tigers to cover the spread, with the best line currently available at DraftKings, according to our live NCAAF odds page.
Louisville vs Clemson Odds, Spread, Lines
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -115 | 62.5 -105o / -115u | +310 |
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -105 | 62.5 -105o / -115u | -400 |
- Louisville vs Clemson Spread: Clemson -10.5
- Louisville vs Clemson Over/Under: 62.5 Points
- Louisville vs Clemson Moneyline: Clemson ML -400 · Louisville ML +310
Louisville vs Clemson College Football Preview
Louisville Cardinals Betting Preview: Shough Me the Money
After bringing in Jack Plummer last year, Jeff Brohm once again dipped into the transfer portal and pulled out Tyler Shough from Texas Tech. In his seventh season, Shough is a veteran who has struggled to stay healthy for most of his career.
His eight starts are already a career-high for a single season, as are his 20 touchdowns and 2,300 yards.
Shough and the Cardinals have a talented wide receiver room led by former five-star recruit Ja’Corey Brooks. The Alabama transfer is averaging 100 yards per game and over 18 yards per catch.
We typically expect Brohm’s teams to have good offenses. They rank 22nd in Success Rate and have been well-balanced on the ground and through the air. The Cardinals are averaging 5.2 yards per carry between running backs Isaac Brown and Duke Watson.
Defense is Louisville’s calling card, but it still ranks 35th in Success Rate on that side of the ball.
It's been solid against the run but do have issues defending the pass. It's also been fortunate not to play many above-average passing attacks, but Georgia Tech, Virginia and Miami all managed to throw for over 300 yards.
Clemson Tigers Betting Preview: Klubnik as Efficient as Ever
For the amount of criticism Klubnik has taken in the past, he deserves the same credit for how good he has been this season. Klubnik has thrown 20 touchdown passes with just three interceptions and is averaging 262.3 yards per game.
Klubnik has thrown multiple touchdown passes in every game since the opener and has at least three in five of his seven games. He ranks fourth in the country in touchdowns. Most of them have been caught by his top receiver, Antonio Williams, and tight end Jake Briningstool.
After running a two-running back system last year, Phil Mafah is finally the bell-cow back and has thrived. He's averaging 97.5 yards per game and has rushed for 6.5 yards per carry. Klubnik has also been using his legs a lot more and it has helped the Tigers extend drives.
Clemson's defense has not been quite as dominant as we have come to expect, but it has been much better after a slow start. The Tigers have allowed just 14 points in or less in three of their last four games.
Their strength has been defending the pass, with a secondary that's strong in coverage and a front seven that ranks third in the country at creating Havoc.
Clemson vs Louisville Matchup Analysis
Toggle the dropdowns below to hide or show how Clemson and Louisville match up statistically:
Louisville Offense vs. Clemson Defense
 | Offense | Defense |  Edge |
| Rush Success | 29 | 96 | |
| Line Yards | 76 | 106 | |
| Pass Success | 31 | 43 | |
| Havoc | 32 | 3 | |
| Finishing Drives | 49 | 109 | |
| Quality Drives | 4 | 35 | |
Clemson Offense vs. Louisville Defense
| Offense | Defense | Edge |
| Rush Success | 14 | 32 | |
| Line Yards | 6 | 47 | |
| Pass Success | 29 | 84 | |
| Havoc | 21 | 89 | |
| Finishing Drives | 7 | 108 | |
| Quality Drives | 5 | 66 | |
Pace of Play / Other
| | |
| PFF Tackling | 78 | 46 |
| PFF Coverage | 90 | 36 |
| Special Teams SP+ | 119 | 103 |
| Middle 8 | 42 | 49 |
| Seconds per Play | 27.6 (78) | 26.3 (49) |
| Rush Rate | 46% (114) | 49% (90) |
How to Make College Football Picks For My Louisville vs Clemson Prediction
Louisville came into the season with big expectations after last year but has been exposed against the better teams it has faced. The three best teams Louisville has faced have all come out victorious.
The Tigers have not played the most difficult schedule, but they are throttling teams. Clemson has won its last six games by an average of 27.3 points per game.
Klubnik has been one of the best quarterbacks in the country, competing 66% of his passes with a 20-3 touchdown to interception ratio. He has the sixth-highest Passer Grade at PFF.
The run game has greatly improved, with Mafah taking over as the lead back. He's averaging 6.5 yards per carry, and Klubnik has been using his legs a lot more to extend drives and keep plays alive.
The Tigers rank 14th in Rush Success Rate and run behind an offensive line that ranks sixth in Line Yards.
I feel bad putting the Cardinals into the fraud category, but that's where they might belong. This team has failed to cover the spread in five straight games. They are 0-2 against the spread as an underdog and 0-3 ATS on the road.
Clemson is in killer mode this season, especially at home. The Tigers have won every home game by at least 17 points, and I expect another double-digit victory here against the Cardinals.
Pick: Clemson -10 (-110) | Play to -12 (-110)
Louisville vs Clemson Start Time, TV Channel, How to Watch
| Location: | Memorial Stadium, Clemson, SC |
| Date: | Saturday, Nov. 2 |
| Kickoff Time: | 7:30 p.m. ET |
| TV / Streaming: | ESPN |
The Louisville Cardinals travel to South Carolina on Saturday to take on the Clemson Tigers at 7:30 p.m. ET on ESPN.
Clemson vs Louisville Betting Trends
- 79% of bets and 69% of the money are on Clemson to cover the spread
- 99% of bets and 99% of the money on the moneyline are on Clemson to win outright
- 52% of bets and 74% of the money are on the over
Betting trends via our live, updating NCAAF public betting & money percentages page.
Clemson vs Louisville Weather
