College football odds for Iowa State vs. Kansas State will be very popular among bettors for Saturday's season-opening Week 0 slate.
The Iowa State Cyclones and Kansas State Wildcats meet in Dublin, Ireland at 12 p.m. ET (ESPN) for the Aer Lingus Classic.
Both teams went opposite directions against the spread (ATS) last year: Iowa State posted a solid 8-6 (ATS) clip (57.1%), while Kansas State struggled at 4-9 ATS (30.8%).
Additionally, Iowa State holds a firm grip in the head-to-head series, going 5-0 ATS over Kansas State in their last five meetings under Matt Campbell’s leadership.
So what is the smartest college football pick for Iowa State vs. Kansas State?
Let me explain why Iowa State vs. Kansas State odds may be multiple points off the true line.
College Football Odds, Pick for Iowa State vs. Kansas State
We have a PRO System that shows exactly how to bet two teams when they're ranked inside the top 25 — just like No. 22 Iowa State and No. 17 Kansas State.
