The Oklahoma Sooners take on the Alabama Crimson Tide in Tuscaloosa, Alabama, on Saturday, Nov. 15. Kickoff is set for 3:30 p.m. ET on ABC.
Alabama is favored by 6 points on the spread with a moneyline of -225. Oklahoma, meanwhile, enters as a +6 underdog and is +185 ont he moneyline to pull off the upset. The over/under sits at 45.5 points.
Here’s my Oklahoma vs. Alabama prediction and college football picks for Saturday, November 15.

Oklahoma vs Alabama Prediction, Picks
- Oklahoma vs. Alabama Picks: Oklahoma +6 or Better · John Mateer Over 27.5 Rushing Yards
My Alabama vs. Oklahoma best bet is on the Sooners to cover the spread and quarterback John Mateer to go over his rushing yards prop. Find the best line available on our live NCAAF odds page.
Oklahoma vs Alabama Odds, Spread, Line
| Oklahoma Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -108 | 45.5 -112o / -108u | +205 |
| Alabama Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -112 | 45.5 -112o / -108u | -250 |
- Oklahoma vs Alabama Spread: Alabama -6.5, Oklahoma +6.5
- Oklahoma vs Alabama Over/Under: 45.5
- Oklahoma vs Alabama Moneyline: Oklahoma ML +205, Alabama ML -250

Oklahoma vs Alabama NCAAF Week 12 Preview
Oklahoma Sooners Betting Preview
Oklahoma will face a third consecutive top-15 team with aspirations of making the College Football Playoff.
Quarterback John Mateer has been lackluster in three games following a meltdown loss against Texas. The Washington State transfer has generated just three all-purpose touchdowns and a couple of turnover-worthy plays.
If there's a notable nugget from the Sooners' last game, Mateer ran for a season-high three explosives while forcing three missed tackles.
The Oklahoma defense continues to be one of the best in the nation, fielding the best rank of all FBS teams in Rushing Success Rate allowed and Defensive Line Yards.
Defensive interior David Stone is one of the best nationally in stopping the run, while edge rushers Taylor Wein and R Mason Thomas have combined for 50 pressures.
This is the second-ranked Havoc unit in the nation without many weaknesses.

Alabama Crimson Tide Betting Preview
Alabama struggled to get a quality game from the offense in an 11-point victory over LSU last week. The Crimson Tide failed to produce a methodical drive, averaging 2.6 yards per play on 25 rushing attempts.
Special teams played a surprise role in the victory over the Tigers, as Alabama ranks 84th in SP+ Special Teams but logged 133 hidden yards in that game.
Quarterback Ty Simpson had an uncharacteristically off night, completing just 21-of-35 passes while lowering his on-target rank to 28th among of all FBS quarterbacks.
Defensive coordinator Kane Wommack has struggled to create a run-stopping defense for Alabama. The Crimson Tide sit outside the top 50 in Rushing Success Rate allowed and Defensive Line Yards.
The coverage unit has been elite in passing downs, but Alabama continues to fail in generating a pass rush.
Teams that can create consistent gains in the trench have troubled Alabama, particularly opposing teams with quarterback mobility.

Oklahoma vs Alabama NCAAF Week 12 Pick
Alabama has had consistent issues with mobile quarterbacks.
South Carolina gave the Tide all it could handle thanks to LaNorris Sellers leading the Gamecocks in rushing yards with a touchdown.
Missouri lost to Alabama by a field goal after a Herculean effort from quarterback Beau Pribula, leading the Tigers in rushing with 61 yards and a touchdown.
Those numbers pale in comparison to the season opener with Tommy Castellanos from Florida State, who went for 78 yards on the ground with a touchdown.
Mateer heated up on designed rush attempts against Tennessee and can be a major factor in the outcome of Week 12.
Simpson may have issues getting the Alabama offense down the field against the Sooners. Oklahoma ranks 10th of all FBS defenses in creating a contested catch, an issue for targets such as Germie Bernard and Ryan Williams.
There will be no help from the run game, as Jam Miller averaged 1.6 yards per carry against LSU. The Tide sit 112th in rush efficiency and are now going against the best run defense in FBS.
Action Network projects Alabama as a 6-point favorite, but the matchups indicate a heavy Oklahoma advantage through defense and on the ground with Mateer.
With the recent history of mobile quarterbacks creating close calls for Alabama, look for Mateer to potentially throw a roadblock in the Crimson Tide's quest to win the SEC.
Pick: Oklahoma +6 or Better · John Mateer Over 27.5 Rushing Yards


















