The UConn Huskies take on the Buffalo Bulls in Buffalo, New York. Kickoff is set for 3:30 p.m. ET on ESPN+.
UConn is favored by -4 points on the spread with a moneyline of -180. The total is set at 49.5 points.
Here’s my UConn vs. Buffalo prediction and college football picks for Saturday, September 27, 2025.
