The Bills (10-4) and Browns (3-11) clash in NFL Week 16 today. Kickoff is set for 1 p.m. ET from Huntington Bank Field in Cleveland, Ohio. Bills vs Browns will broadcast on CBS.
The Bills are 10.5-point favorites on the spread (Bills -10.5; -107), with the over/under set at 40.5 (-115o / -105u). Buffalo is a -590 favorite on the moneyline, while Cleveland is +425 to pull off the upset.
Let's get into my Bills vs Browns predictions for NFL Week 16 — plus the latest odds, betting trends, injury reports and weather forecast.
Bills vs Browns Predictions & Picks
- Bills vs Browns pick: Under 41.5 (-115)
My Browns vs Bills best bet is on the under, with the best price currently available at bet365. However, make sure to find the best lines by checking our live NFL odds page.
Bills vs Browns Odds
| Buffalo Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -107 | 40.5 -115o / -105u | -590 |
| Cleveland Browns Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -114 | 40.5 -115o / -105u | +425 |
Bills vs Browns Preview
At the time of writing, it's unclear if the Browns are going to have a functional offensive line in this game.
G Joel Bitonio missed practice Wednesday and logged a limited one on Thursday due to a knee injury while T Jack Conklin is dealing a concussion. G Teven Jenkins is dealing with a shoulder injury, and David Njoku, their best blocking tight end, seems to miss practice the first two days every week — he didn't play last week logged DNPs Wednesday and Thursday.
RB Dylan Sampson, who has provided some juice out of the backfield in the receiving game, has also been a DNP for most of the week with a hand injury.
Long story short: The Browns offense is injury ravaged, which is bad news for Shedeur Sanders, who came crashing back down to earth in a 31-3 loss to the Bears last week.
That's what I was afraid of, which is why I didn't bet the Browns in that game, and it's looking like this is setting up for a similar kind of result against the Bills today.
Bills vs Browns Predictions, Over/Under Analysis
The Bills are a little bit overrated, in my opinion. They beat the Bengals at home and needed a miracle comeback against the Patriots. The defense remains flawed and nothing to write home about.
There's going to be a ton of running in this game from both teams, which will constantly bleed clock.
Bills vs Browns Best Bet
- Under 41.5 (-115)
Bills vs Browns Betting Trends
Bills vs Browns Viewing Info: Channel, Start Time, Streaming
| Location: | Huntington Bank Field in Cleveland, Ohio |
| Date: | Sunday, Dec. 21 |
| Time: | 1 p.m. ET |
| TV / Streaming Options: | CBS |
For the latest on NFL injuries, be sure to check out our NFL Injury Report page.
