NFL Week 1 for the 2025 season starts with the Dallas Cowboys and Philadelphia Eagles facing off on Thursday Night Football on Sept. 4. Cowboys vs Eagles will kick off at 8:20 p.m. ET from Lincoln Financial Field; the game will be broadcast on NBC and Peacock.
The Eagles are 8-point favorites on the spread against the Cowboys (Eagles -8) with the over/under set at 48.5. The Eagles are -455 moneyline favorites while the Cowboys are +345 underdogs.
Let's get to our Cowboys vs Eagles picks, player props and predictions for Thursday night.
Cowboys vs Eagles Predictions, Props, Best Bets
- Cowboys vs Eagles against the spread: Cowboys +8.5 (-115)
- Cowboys vs Eagles total: Over 47.5 (-120)
- Cowboys vs Eagles Anytime Touchdown: A.J. Brown Anytime Touchdown Scorer (+165)
Cowboys vs Eagles Odds, Lines
| Cowboys Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8 -110 | 48.5 -110o / -110u | +345 |
| Eagles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8 -110 | 48.5 -110o / -110u | -455 |
Cowboys vs Eagles Same Game Parlay
You can parlay our 3 picks at Fanatics for a +720 SGP on Thursday night.
- Cowboys +8.5
- Over 47.5
- A.J. Brown Anytime Touchdown
Cowboys vs Eagles Parlay Odds: +720
Cowboys vs Eagles Against the Spread Prediction
The public has too many memories of the Cowboys failing in primetime — often, in spectacular fashion by the double-digit variety.
The Eagles are getting more than 60% of the bets against the number, but that doesn’t even account for the hoard of casual bettors who will use the moneyline in some fashion. Looking at betting data has no influence on what actually happens on the field, but it has undoubtedly created value on the underdog with the line ballooning to 8.5 points.
The perception of teams based on previous results that occurred in the prior season weigh too heavily on early season spreads, which is why, historically, backing underdogs in Week 1 has been highly profitable.
Over the last nine seasons, road underdogs have covered at a 59% rate in Week 1. More specifically, if an underdog is within the division or an underdog of more than six points, both angles have delivered a cover rate of 65% or better during that same time span in Week 1.
The Eagles dominated the Cowboys in both meetings in 2024, but Dak Prescott did not play in either contest.
Over the last three meetings between Philly and Prescott, the Cowboys quarterback has averaged 330 passing yards per game with eight total passing touchdowns against 1 interception. Dallas also won two of those three games.
Take the points in the season opener on Thursday night.
Pick: Cowboys +8.5 (-115)
Cowboys vs Eagles Over/Under Prediction
By Billy Ward
The Eagles-Cowboys season opener has a tough total to break down, at least using the methods I traditionally start with.
The Eagles have the edge in the trenches, but that extends to both sides of the ball, which is effectively a wash in terms of points produced.
The favored Eagles played at a roughly league average pace when leading last season, and while they have vowed to lean more heavily on the pass in 2025, I’m not sure that extends to scenarios when they’re easily controlling games.
However, one of the most important lessons I’ve learned from years of playing DFS is that it’s not so much about how an offense matches up with an opposing defense, but how the offenses in a game compare with each other.
We know how good the Eagles offense can be. The defending champs were a top-five team in points per game last season, and they’ve returned almost an identical offensive unit and coaching staff, plus have hopefully gotten over the chemistry issues that plagued them early in 2024.
What the market could be overlooking is how good the Cowboys offense is with a healthy Dak Prescott. They led the NFL in scoring in 2023 when he was fully healthy, and would’ve been a top-10 unit last season if we only counted games that Prescott started and finished.
The Cowboys should be able to hit enough big plays to push for upwards of 20 points even against a tough Eagles defense, which means the Eagles won’t let up until they’re approaching 30.
With the total settling in at 47.5, this one will sneak across the line if the Cowboys can hang in there.
Pick: Over 47.5 (-120)
Cowboys vs Eagles Anytime Touchdown Prop
By Grant Neiffer
Brown is the clear WR1 in the Eagles offense, and he's a little underpriced considering the spot.
The Eagles had an incredibly run-heavy offense last season, but according to reports, they will try and be a little more pass-heavy this season to take the strain off of Saquon Barkley and Jalen Hurts.
The Cowboys were near the top of the league in passing touchdowns allowed last season (eighth most), and with Micah Parsons no longer on the team, their pass defense is going to take a huge hit.
Brown scored in 9-of-17 games he played in last season (playoffs included).
While I don't love that the Eagles are favored by over a touchdown, these odds are too high to pass up.
Pick: A.J. Brown Anytime Touchdown Scorer (+165)
