Cubs vs. Padres Odds & Betting Predictions - April 28, 2026

Cubs at Padres

1:40 am • MARQ

Chicago Cubs

San Diego Padres

pitcher		team	era	w-l
R.Vasquez			1.88	2-0
M.Boyd			5.79	1-1

MatchupOpenSpreadTotalMoneyline
Cubs 17-10	-1.5	-1.5+145	o8-110	-115
Padres 18-8	u8	+1.5-175	u8-112	-105

Tuesday 1:40 a.m.

April 28, 2026

Petco ParkSan Diego

63°Fahrenheit

0%Rain

9Wind

Over 0.5 (1st Inn)+115

0.67u

#EV 6.19% Pinny -105 FD -113

Under 8-105

0.53u

Bet to -115

Under 8-105

1.05u

(DK) 94 PRF, cool temps, forecast historically more suppressive by 7-8% - see notes on F5 – two strong defenses (CHC best) – SDP best bullpen estimators MLB (Would decrease to 0.5u at 7.5)

CHC -128 (F5)

0.64u

(FD) Vasquez has been impressive (19.3 K-BB%), but still 13.5% Barrels/BBE (4.33 xERA), Boyd 2.02 SIERA/3.74 xERA through 3 starts – CHC proj LU 21 pt wRC+ edge v L/RHP since LY, teams separated by 35 points this year – CHC 11 Runs Prevented, proj LU 15 FRV best in MLB – SDP far better pen though, so F5 (Would only play to -135)

SD +100

0.5u

No props found

MLB Public Betting

Padres are 4-1 in their last 5 games.
Padres are 2-3 in their last 5 games against the spread
Padres are 7-6 in their road games against the spread
The totals have gone OVER in 1 of Padres' last 5 games
The totals have gone OVER in 6 of Padres' 13 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Padres	17-9	10-3	7-6	10-4	7-5
Cubs	14-13	9-7	5-6	8-9	6-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Padres	10-15-1	6-6-1	4-9	5-8-1	5-7
Cubs	17-10	9-7	8-3	9-8	8-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Padres	18-8	9-4	9-4	11-3	7-5
Cubs	17-10	11-5	6-5	11-6	6-4

date	opponent	score	spread	over/under	moneyline
Apr 26th	@ARI	L 7-12	-1.5 L	O 14.5	ARI -135
Apr 25th	@ARI	W 6-4	-	U 16	SD -106
Apr 23rd	@COL	W 10-8	-1.5 W	O 10.5	SD -155
Apr 23rd	@COL	L 3-8	-1.5 L	U 12	COL -161
Apr 22nd	@COL	W 1-0	-1.5 L	U 11	SD -147

Vince Velasquez
SP
Velasquez is out with elbow
Out
Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out

Joe Musgrove
SP
Musgrove is out with elbow
Out
Griffin Canning
SP
Canning is out with achilles
Out
Will Wagner
3B
Wagner is out with oblique
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
LM.Boyd, P		1-1	5.79	1.143	14.14

HITTERS	AVG	OBP	SLG	HR
1N.Hoerner, 2B	.309	.381	.482	4
2M.Busch, 1B	.208	.283	.297	2
3A.Bregman, 3B	.259	.333	.384	3
4I.Happ, LF	.245	.357	.500	7
5S.Suzuki, RF	.327	.439	.564	4
6M.Ballesteros, DH	.397	.446	.690	4
7D.Swanson, SS	.200	.336	.433	6
8P.Crow-Armstrong, CF	.235	.291	.314	1
9M.Amaya, C	.234	.345	.383	2

PITCHER		W-L	ERA	WHIP	K/9
RR.Vasquez, P		2-0	1.88	1.081	9.42

HITTERS	AVG	OBP	SLG	HR
1R.Laureano, LF	.255	.314	.468	4
2F.Tatis, RF	.250	.330	.292	0
3J.Merrill, CF	.204	.278	.357	3
4M.Machado, 3B	.198	.324	.291	2
5X.Bogaerts, SS	.280	.362	.430	4
6M.Andujar, DH	.316	.350	.439	0
7T.France, 1B	.265	.306	.559	3
8F.Fermin, C	.186	.315	.256	0
9J.Cronenworth, 2B	.163	.295	.225	1