Guardians vs. Reds Odds & Betting Predictions - May 16, 2025

Guardians at Reds

9:10 pm • CLEG
4 - 5
Starting Pitchers
pitcherteameraw-l
Brady Singer logoB.SingerCincinnati Reds logo5.015-2
Tanner Bibee logoT.BibeeCleveland Guardians logo4.063-4

Guardians at Reds Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
25-19
-1.5
-1.5+130
o9.5+100
-122
Reds
22-24
u9
+1.5-156
u9.5-119
+102
location pinFriday 9:10 p.m.
May 16, 2025
Great American Ball ParkCincinnati
Guardians vs. Reds Expert Picks
The Degenerates
The Degenerates
Last 30d: 80-70-2 (-2.2u)
CLE -116 (Live)
1.16u
Greg DiNardo
Greg DiNardo
Last 30d: 81-73-1 (+5.1u)
CLE -121
1.21u
Allan Lem
Allan Lem
Last 30d: 47-47-0 (-1.7u)
B.Singer u4.5 Ks+108
0.5u
This one showed up in the ScoresAndOdds model and I like it at plus odds. Cleveland ranks 20th this season in strikeout rate vs RHP (20.7%). Active roster has struck out 15.6% against Singer in their career.
Grant Neiffer
Grant Neiffer
Last 30d: 33-116-6 (+25.3u)
K.Manzardo o0.5 HR+340
0.5u
Lines at Lunch
Lines at Lunch
Last 30d: 70-74-3 (-9.8u)
Under 9-115
1.15u
Ryan Sura
Ryan Sura
Last 30d: 56-71-2 (-11.2u)
Under 9-115
1.15u
Billy Ward
Billy Ward
Last 30d: 28-47-6 (-21.1u)
Over 0.5 (1st Inn)+100
1.05u
Cam Is Money
Cam Is Money
Last 30d: 108-133-8 (-32.6u)
CLE -118 (F5)
1.18u
Sean Zerillo
Sean Zerillo
Last 30d: 143-164-10 (-11.1u)
Over 9-105
0.53u
Bet to -115

Guardians vs. Reds Previews & Analysis

  • 3 MLB NRFI & YRFI Picks for Friday article feature image

    3 MLB NRFI & YRFI Picks for Friday

    Billy Ward
    May 16, 2025 UTC
  • Guardians vs. Reds: 2 HR Bets for Friday article feature image

    Guardians vs. Reds: 2 HR Bets for Friday

    Grant Neiffer
    May 16, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Reds Public Betting Percentages

Away Logo

Guardians

Public

67%

Bets%

33%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Reds
24-2212-1112-1110-1014-11
Guardians
20-2411-119-139-911-14

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Reds
18-27-18-14-110-135-14-112-13
Guardians
21-20-38-13-113-7-211-710-12-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Reds
22-2411-1211-1211-911-14
Guardians
25-1914-811-1113-512-13

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 15thCWSW 7-1-1.5 WU 9CIN -245
May 14thCWSL 2-4-1.5 LU 8.5CWS -197
May 13thCWSL 1-5-1.5 LU 9CWS -210
May 11th@HOUL 0-6+1.5 LU 8.5HOU +124
May 10th@HOUW 13-9+1.5 WO 8CIN +105

Guardians vs. Reds Injury Updates

Guardians Injuries

  • Shane Bieber
    P

    Bieber is out with elbow

    Out

  • John Means
    P

    Means is out with elbow

    Out

  • Lane Thomas
    OF

    Thomas is out with wrist

    Out

  • David Fry
    C

    Fry is out with elbow

    Out

Reds Injuries

  • Jake Fraley
    OF

    Fraley is out with calf

    Out

  • Noelvi Marte
    IF

    Marte is day-to-day with side

    Day-to-Day

  • Brandon Williamson
    P

    Williamson is out for season with elbow

    Out for Season

  • Julian Aguiar
    P

    Aguiar is out for season with elbow

    Out for Season

  • Rhett Lowder
    P

    Lowder is out with elbow

    Out

  • Carson Spiers
    P

    Spiers is out with shoulder

    Out

Guardians vs. Reds Box Score
Guardians Player Stats
Projected
PITCHERPCIPKER
Tanner Bibee logoRT.Bibee, P105644
Matt Festa logoRM.Festa, P28230
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF0-3100
Nolan Jones logo2N.Jones, CF0-4000
Jose Ramirez logo3J.Ramirez, 3B1-4111
Kyle Manzardo logo4K.Manzardo, DH1-4100
Carlos Santana logo5C.Santana, 1B1-4002
Daniel Schneemann logo6D.Schneemann, 2B1-3000
Gabriel Arias logo7G.Arias, SS0-2000
Bo Naylor logo8B.Naylor, C1-3111
Will Brennan logo9W.Brennan, RF0-3000
Reds Player Stats
Projected
PITCHERPCIPKER
Brady Singer logoRB.Singer, P90543
Taylor Rogers logoLT.Rogers, P12100
Graham Ashcraft logoRG.Ashcraft, P5100
Tony Santillan logoRT.Santillan, P11101
Emilio Pagan logoRE.Pagan, P16110
HITTERSH-ABRHRRBI
TJ Friedl logo1T.Friedl, CF0-3000
Santiago Espinal logo2S.Espinal, 3B1-4000
Elly De La Cruz logo3E.De La Cruz, SS1-3000
Austin Hays logo4A.Hays, LF2-4111
Gavin Lux logo5G.Lux, DH2-4100
Spencer Steer logo6S.Steer, 1B1-4100
Tyler Stephenson logo7T.Stephenson, C1-4000
Will Benson logo8W.Benson, RF2-4113
Matt McLain logo9M.McLain, 2B1-4100

Guardians vs. Reds Odds Comparison

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Guardians at Reds Team Totals

MatchupOverUnder
Guardians
25-19
o4.5-125
u4.5-105
Reds
22-24
o4.5+105
u4.5-135