The Seattle Mariners host the Athletics on April 22, 2026. First pitch from T-Mobile Park is scheduled for 4:10 p.m. EDT. The game will be broadcast on SEAM.
The Mariners are favored by -190 on the moneyline and by -1.5 (+114) on the run line. The Athletics are +160 on the moneyline and +1.5 (-137) on the run line. The total is set at 7.5 runs (-115 / -105).
Find my MLB picks and A's vs Mariners prediction below, as well as probable pitchers, weather report, and more.
A's vs Mariners Predictions, Pick
- A's vs Mariners Pick: A's ML (+150 or Better)
My Athletics vs Mariners best bet is on the A's to win outright. Make sure to find the best odds by checking our live MLB odds page.
A's vs Mariners Odds, Run Line, and Over/Under
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -137 | 7.5 -115o / -105u | +160 |
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +114 | 7.5 -115o / -105u | -190 |
- A's vs Mariners moneyline: Athletics +160, Mariners -190
- A's vs Mariners over/under: 7.5 (-115 / -105)
- A's vs Mariners spread: Mariners -1.5 (+114), Athletics +1.5 (-137)
A's vs Mariners Probable Pitchers
| Aaron Civale (RHP, ATH) | Stat | Logan Gilbert (RHP, SEA) |
|---|---|---|
| 2-1 | W-L | 1-3 |
| 0.3 | fWAR (FanGraphs) | 0.8 |
| 3.54 / 4.01 | ERA / xERA | 4.03 / 3.06 |
| 3.87 / 4.48 | FIP / xFIP | 2.89 / 3.11 |
| 1.33 | WHIP | 1.17 |
| 11.2% | K-BB% | 23.5% |
| 38.5% | GB% | 32.9% |
| 94 | Stuff+ | 108 |
| 112 | Location+ | 113 |
A's vs Mariners Expert MLB Pick
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
This system targets divisional underdogs in MLB regular-season games that receive low public support but show signs of sharp action or value.
These dogs have moneyline support from less than 30% of bettors, yet still experience little or no negative line movement, suggesting the smart money is holding the line.
Additionally, these bets occur in division games, where familiarity and tighter matchups often reduce the gap between underdog and favorite.
The bet count is modestly above average, further hinting at targeted action rather than mass public overreaction.
How To Make A's vs Mariners Picks
I’ve been all over the A’s in this series against the Mariners.
While the Mariners have a massive starting pitching and bullpen advantage — as they will again in this game — my numbers project the Athletics as the better offensive, defensive, and base-running team.
As a result, I project the A’s closer to +130 on the ML.
Pick: A's ML (+150 or Better)
