Michigan St vs. USC Odds & Betting Predictions - September 21, 2025

Michigan St at USC

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Michigan State Spartans

@

USC Trojans

MatchupOpenSpreadTotalMoneyline
Michigan St 3-0	+14.5	+14.5-107	o56.5-110	+470
USC 3-0	u56.5	-14.5-112	u56.5-110	-610

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Sunday 3:00 a.m.

September 21, 2025

Los Angeles Memorial ColiseumLos Angeles

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74°Fahrenheit

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0%Rain

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4Wind

No props found

NCAAF Public Betting

USC are 3-0 in their last 5 games.
USC are 2-1 in their last 5 games against the spread
USC are 0-1 in their road games against the spread
The totals have gone OVER in 2 of USC' last 3 games
The totals have gone OVER in 2 of USC' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
USC	2-1	2-0	0-1	2-1	N/A
Michigan St	0-3	0-3	N/A	0-3	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
USC	2-1	2-0	0-1	2-1	N/A
Michigan St	2-1	2-1	N/A	2-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
USC	3-0	N/A	N/A	3-0	N/A
Michigan St	3-0	N/A	N/A	3-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 13th	@PUR	W 33-17	-20.5 L	U 59.5	USC -1600
Sep 6th	GASO	W 59-20	-29 W	O 62.5	USC -7000
Aug 30th	MOST	W 73-13	-36.5 W	O 60	USC -9000
Dec 28th	TA&M	W 35-31	-	-	-
Nov 30th	ND	L 35-49	+7 L	O 52.5	ND +207

Total

Passing

386

YDS

810

36/53

Comps/Atts

44/57

7.28

YPA

14.21

5/1

TDs/INTs

7/0

8/64

Sacks/Yards

1/5

Rushing

330

Rush Yards

542

79

Attempts

63

4.18

YPC

8.6

3

TDs

10

Turnovers

Fumbles Lost

1

Interceptions

0

Efficiency

8/9 88.9%

Redzone

12/12 100%

9/25 0%

3rd Down

11/16 0%

2/3 0%

4th Down

0/0 0%

First Downs

41

Total

55

19

Pass

29

16

Rush

21

6

Penalty

5

Misc

/

Penalties/Yards

/

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See more NCAAF Odds

MatchupOverUnder
Michigan St 3-0	N/A	N/A
USC 3-0	N/A	N/A