Cowboys vs. Buffaloes Odds & Betting Predictions - September 21, 2025

Cowboys at Buffaloes

2:15 am • ESPN

Wyoming Cowboys

20

20 - 37

Colorado Buffaloes

37

MatchupOpenSpreadTotalMoneyline
Cowboys 4-8	+17.5	+12.5-112	o45.5-110	+350
Buffaloes 3-9	u47.5	-12.5-108	u45.5-110	-470

location pin

Sunday 2:15 a.m.

September 21, 2025

Folsom FieldBoulder

Over 45.5-110

1u

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NCAAF Public Betting

Buffaloes are 1-4 in their last 5 games.
Buffaloes are 1-4 in their last 5 games against the spread
Buffaloes are 1-4 in their road games against the spread
The totals have gone OVER in 3 of Buffaloes' last 5 games
The totals have gone OVER in 3 of Buffaloes' 7 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Buffaloes	5-7	4-3	1-4	2-0	3-7
Cowboys	5-7	3-3	2-4	3-1	2-6

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Buffaloes	5-7	3-4	2-3	1-1	4-6
Cowboys	2-10	1-5	1-5	0-4	2-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Buffaloes	3-9	N/A	N/A	2-0	1-9
Cowboys	4-8	N/A	N/A	3-1	1-7

date	opponent	score	spread	over/under	moneyline
Sep 12th	@HOU	L 20-36	+4 L	O 45.5	HOU +160
Sep 6th	DEL	W 31-7	-23.5 W	U 49.5	COLO -2800
Aug 30th	GT	L 20-27	+3 L	U 49.5	GT +136
Dec 29th	BYU	L 14-36	-3 L	U 55	BYU -155
Nov 29th	OKST	W 52-0	-14.5 W	U 67	COLO -650

Total

347

Total Yards

497

67

Total Plays

59

5.17910447761194

Yards Per Play

8.423728813559322

Passing

182

YDS

304

12/26

Comps/Atts

18/28

7

YPA

10.857142857142858

2/0

TDs/INTs

3/0

2/12

Sacks/Yards

1/14

Rushing

165

Rush Yards

193

41

Attempts

31

4.024390243902439

YPC

6.225806451612903

0

TDs

2

Turnovers

0

Fumbles Lost

1

0

Interceptions

0

Efficiency

3/3 100%

Redzone

1/2 50%

5/13 0%

3rd Down

5/10 0%

1/1 0%

4th Down

0/0 0%

First Downs

20

Total

23

8

Pass

12

8

Rush

8

4

Penalty

3

Misc

7/80

Penalties/Yards

5/53

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MatchupOverUnder
Cowboys 4-8	o16.5-117	u16.5-112
Buffaloes 3-9	o28.5-114	u28.5-112