College Football Spread Prediction: Eastern Michigan vs. Buffalo Sharp Betting Pick (Tuesday, November 21)

College Football Spread Prediction: Eastern Michigan vs. Buffalo Sharp Betting Pick (Tuesday, November 21) article feature image
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Photo by Gregory Fisher/Icon Sportswire via Getty Images. Pictured: Buffalo Bulls Running Back Ron Cook Jr. (2) runs

College Football Odds, Prediction: Eastern Michigan vs. Buffalo

Eastern Michigan Odds+5.5
Buffalo Odds-5.5
Over/Under37.5
DateTuesday, Nov. 21
Time7:30 p.m. ET
ChannelESPN2

*College football odds as of Tuesday afternoon

The final full week of the college football season gets underway tonight with a two-game MACtion schedule.

And yes, that also means that this is the last weeknight MACtion slate of the season as well.

Don't cry because it's almost over. Smile because it happened.

And let's give the final weeknight MACtion slate of the season the send-off it deserves by leveraging the Action Network's PRO betting tools to determine the smartest college football spread prediction for Eastern Michigan vs. Buffalo on Tuesday night.

If you are looking for a new sportsbook, check out our sportsbook reviews and find the best one for you!

College Football Spread Prediction: Eastern Michigan vs. Buffalo

Buffalo has settled in as a 5.5-point favorite against Eastern Michigan as of the time of writing, though it's important to also examine how the wiseguys have shaped this spread as well.