Astros vs. Guardians Odds & Betting Predictions - April 21, 2026

Astros at Guardians

10:10 pm • CLEG

Houston Astros

10-16

5 - 8

Cleveland Guardians

14-12

pitcher		team	era	w-l
P.Messick			1.76	3-0
R.Weiss			6.50	0-2

MatchupOpenSpreadTotalMoneyline
Astros 10-16	+1.5	+1.5-156	o8.5-129	+129
Guardians 14-12	u8	-1.5+132	u8.5+100	-101

Tuesday 10:10 p.m.

April 21, 2026

Progressive FieldCleveland

P.Messick u16.5 Outs-112

0.89u

D.Harris u0.5 Hits+105

1.05u

Over 8.5-115

0.87u

Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy

CLE -145

0.69u

Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy

S.Kwan o1.5 Hits + Runs + RBIs-125

0.8u

K.Manzardo o0.5 HR+518

0.1u

P.Messick u5.5 Ks-162

Over 8.5-115

Y.Alvarez o0.5 HR+360

0.25u

@gneiffer07 ⭐️ https://myaction.app/IPqH1gLpw2b

J.Ramirez o1.5 Hits + Runs + RBIs-132

$1.00

HOU o3.5-120

P.Messick u17.5 Outs-134

HOU +125

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No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 6-7 in their road games against the spread
The totals have gone OVER in 3 of Guardians' last 5 games
The totals have gone OVER in 6 of Guardians' 13 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	15-11	9-4	6-7	7-5	8-6
Astros	10-16	6-7	4-9	4-11	6-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	13-13	6-7	7-6	6-6	7-7
Astros	17-8-1	9-4	8-4-1	9-6	7-2-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	14-12	8-5	6-7	7-5	7-7
Astros	10-16	7-6	3-10	5-10	5-5

date	opponent	score	spread	over/under	moneyline
Apr 20th	HOU	L 2-9	-1.5 L	O 7.5	HOU -135
Apr 19th	BAL	W 8-4	+1.5 W	O 6.5	CLE -120
Apr 18th	BAL	W 4-2	-1.5 W	U 7.5	CLE -146
Apr 17th	BAL	L 4-6	-1.5 L	O 8	BAL -141
Apr 16th	BAL	W 4-2	-1.5 W	U 8	CLE -136

Zach Dezenzo
LF
Dezenzo is out with elbow
Out

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PITCHER	PC	IP	K	ER
RR.Weiss, P	86	3.1	4	2
LC.Gordon, P	16	1	1	0
RK.Teng, P	31	2.2	2	0
RE.De Los Santos, P	15	0.1	0	3
LB.King, P	15	0.2	0	3

HITTERS	H-AB	R	RBI
1C.Correa, SS	2-4	0	1
2Y.Alvarez, DH	2-5	0	3
3J.Altuve, 2B	0-5	0	0
4C.Walker, 1B	0-4	0	0
5I.Paredes, 3B	1-3	1	0
6C.Smith, RF	2-4	1	0
7Y.Diaz, C	1-4	1	0
8B.Matthews, CF	2-3	1	1
8B.Matthews, LF	2-3	1	1
9D.Harris, LF	0-1	1	0
9D.Johnson, CF	0-0	0	0

PITCHER	PC	IP	K	ER
LP.Messick, P	85	5	4	3
RS.Armstrong, P	11	1	0	0
RC.Brogdon, P	11	0.1	0	0
LT.Herrin, P	16	0.2	0	0
RP.Pallette, P	21	1	0	0
RC.Smith, P	18	1	1	1

HITTERS	H-AB	R	HR	RBI
1S.Kwan, CF	1-3	1	0	0
2C.DeLauter, DH	1-4	1	0	3
3J.Ramirez, 3B	1-3	2	0	0
4K.Manzardo, 1B	2-4	0	0	2
5G.Valera, RF	1-5	0	0	1
6D.Schneemann, 2B	1-2	1	0	0
7A.Martinez, LF	2-4	2	1	1
8A.Hedges, C	1-2	0	0	0
8B.Naylor, PH	0-2	0	0	0
8B.Naylor, C	0-2	0	0	0
9B.Rocchio, SS	1-4	1	0	1