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Astros vs. Guardians Odds & Betting Predictions - April 20, 2026

Astros at Guardians

10:10 pm • CLEG

Houston Astros

10-16
9
9 - 2

Cleveland Guardians

14-12
2
Starting Pitchers
pitcherteameraw-l
Slade Cecconi logoS.CecconiCleveland Guardians logo6.200-3
Spencer Arrighetti logoS.ArrighettiHouston Astros logo2.462-0

Astros at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
10-16
+1.5
+1.5-188
o7.5-112
+115
Guardians
14-12
u8.5
-1.5+161
u7.5-108
-135
location pinMonday 10:10 p.m.
April 20, 2026
Progressive FieldCleveland
Astros vs. Guardians Expert Picks
Picks Office
Picks Office
Last 30d: 196-188-9 (-4.8u)
CLE -125
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Sean Zerillo
Sean Zerillo
Last 30d: 162-162-12 (-10.5u)
HOU +115
0.58u
Bet to +108
Wags Wins
Wags Wins
Last 30d: 223-252-2 (-17.6u)
HOU +115
1.44u
Scott Rickenbach
Scott Rickenbach
Last 30d: 94-118-4 (-31.4u)
CLE -114
1u
OldSchool0909
Last 30d: 159-182-0 (+3.4u)
HOU +102
1.02u
Picks Office
Picks Office
Last 30d: 196-188-9 (-4.8u)
Under 7.5-115
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Grant Neiffer
Grant Neiffer
Last 30d: 31-119-4 (+11.8u)
Y.Alvarez o0.5 HR+450
0.25u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 102-139-9 (+10.2u)
Under 8-118
0.25u
@Tannerstruth ⭐️ https://myaction.app/CL26XueLu2b
Derek Carty
Derek Carty
Last 30d: 22-45-4 (+1.1u)
S.Arrighetti u4.5 Ks+125
1.25u
There is a value opportunity on Spencer Arrighetti's strikeouts prop. THE BAT X is projecting him to record 4.38 strikeouts, while oddsmakers are implying 4.97. The model believes there is a 56% chance he records fewer than 5 strikeouts, so there is value on the under at +125. This play is good down to at least +106. Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics https://evanalytics.com/subscribe/mlb?ref=zdlkmgz
Doug Ziefel
Doug Ziefel
Last 30d: 286-382-23 (-24.2u)
S.Cecconi u4.5 Hits Allowed+105
0.48u
Frank Ammirante
Frank Ammirante
Last 30d: 282-326-14 (-5.7u)
Under 7.5+100
1u
Sean Zerillo
Sean Zerillo
Last 30d: 162-162-12 (-10.5u)
Under 8.5-128
0.64u
Bet to 7.5 (-102)
Cam Is Money
Cam Is Money
Last 30d: 110-102-2 (+8.7u)
CLE -109
1.09u

Astros vs. Guardians Previews & Analysis

  • Astros vs Guardians: Pure Weather Under article feature image

    Astros vs Guardians: Pure Weather Under

    Tanner McGrath•
    Apr 20, 2026 UTC
  • Grant's 5 Home Run Bets for Monday article feature image

    Grant's 5 Home Run Bets for Monday

    Grant Neiffer•
    Apr 20, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Guardians Public Betting Percentages

Away Logo

Astros

Public

Home Logo

Guardians

31%

Bets%

69%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Guardians are 3-2 in their last 5 games.
  • Guardians are 3-2 in their last 5 games against the spread
  • Guardians are 6-7 in their road games against the spread
  • The totals have gone OVER in 3 of Guardians' last 5 games
  • The totals have gone OVER in 6 of Guardians' 13 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians		15-119-46-77-58-6
Astros		10-166-74-94-116-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians		13-136-77-66-67-7
Astros		17-8-19-48-4-19-67-2-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians		14-128-56-77-57-7
Astros		10-167-63-105-105-5

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 19thBALW 8-4+1.5 WO 6.5CLE -120
Apr 18thBALW 4-2-1.5 WU 7.5CLE -146
Apr 17thBALL 4-6-1.5 LO 8BAL -141
Apr 16thBALW 4-2-1.5 WU 8CLE -136
Apr 15th@STLL 3-5-U 9STL -112

Guardians vs. Astros Injury Updates

Guardians Injuries

    Astros Injuries

    • Zach Dezenzo
      LF

      Dezenzo is out with elbow

      Out

    See more MLB Injuries Right Arrow
    Astros vs. Guardians Box Score
    Astros Player Stats
    Projected
    PITCHERPCIPKER
    Spencer Arrighetti logoRS.Arrighetti, P96532
    Steven Okert logoLS.Okert, P15100
    AJ Blubaugh logoRA.Blubaugh, P15110
    Jayden Murray logoRJ.Murray, P39220
    HITTERSH-ABRHRRBI
    Carlos Correa logo1C.Correa, SS3-5102
    Yordan Alvarez logo2Y.Alvarez, DH1-5000
    Jose Altuve logo3J.Altuve, 2B0-5000
    Christian Walker logo4C.Walker, 1B3-5312
    Isaac Paredes logo5I.Paredes, 3B3-5222
    Taylor Trammell logo6T.Trammell, CF1-1000
    Cam Smith logo6C.Smith, PR0-2101
    Cam Smith logo6C.Smith, RF0-2101
    Yainer Diaz logo7Y.Diaz, C1-4001
    Dustin Harris logo8D.Harris, RF0-3100
    Dustin Harris logo8D.Harris, LF0-3100
    Brice Matthews logo9B.Matthews, LF1-3101
    Brice Matthews logo9B.Matthews, CF1-3101
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Slade Cecconi logoRS.Cecconi, P94526
    Matt Festa logoRM.Festa, P22211
    Tim Herrin logoLT.Herrin, P19100
    Connor Brogdon logoRC.Brogdon, P19111
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, CF0-4000
    Chase DeLauter logo2C.DeLauter, RF0-4000
    Jose Ramirez logo3J.Ramirez, 3B1-4200
    Kyle Manzardo logo4K.Manzardo, 1B1-5000
    Rhys Hoskins logo5R.Hoskins, DH2-4001
    George Valera logo6G.Valera, LF1-3001
    Juan Brito logo7J.Brito, 2B0-3000
    Bo Naylor logo8B.Naylor, C0-4000
    Brayan Rocchio logo9B.Rocchio, SS3-3000

    Astros vs. Guardians Odds Comparison

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    Astros at Guardians Team Totals

    MatchupOverUnder
    Astros
    10-16
    N/A
    N/A
    Guardians
    14-12
    N/A
    N/A