Astros vs. Guardians Odds & Betting Predictions - April 20, 2026
Astros at Guardians
10:10 pm • CLEGStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 5.18 | 3-5 | ||
![]() | 1.32 | 6-1 |
Astros at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Astros 23-31 | +1.5 | +1.5-188 | o7.5-112 | +115 |
Guardians 32-23 | u8.5 | -1.5+161 | u7.5-108 | -135 |

Progressive FieldCleveland
Astros vs. Guardians Expert Picks
Picks Office
Last 30d: 155-155-12 (-9.2u)
CLE -125
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy

Sean Zerillo
Last 30d: 175-145-12 (+6.1u)
HOU +115
0.58u
Bet to +108
Wags Wins
Last 30d: 222-295-5 (-92.5u)
HOU +115
1.44u
Scott Rickenbach
Last 30d: 44-43-2 (-0.3u)
CLE -114
1u
OldSchool0909
Last 30d: 57-67-0 (-1.7u)
HOU +102
1.02u
Picks Office
Last 30d: 155-155-12 (-9.2u)
Under 7.5-115
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Grant Neiffer
Last 30d: 26-113-7 (+1.3u)
Y.Alvarez o0.5 HR+450
0.25u
Payoff Pitch Podcast
Last 30d: 76-101-9 (-7.2u)
Under 8-118
0.25u
@Tannerstruth ⭐️ https://myaction.app/CL26XueLu2b
Derek Carty
Last 30d: 25-48-4 (+3.5u)
S.Arrighetti u4.5 Ks+125
1.25u
There is a value opportunity on Spencer Arrighetti's strikeouts prop. THE BAT X is projecting him to record 4.38 strikeouts, while oddsmakers are implying 4.97. The model believes there is a 56% chance he records fewer than 5 strikeouts, so there is value on the under at +125. This play is good down to at least +106.
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Doug Ziefel
Last 30d: 188-139-2 (+22.1u)
S.Cecconi u4.5 Hits Allowed+105
0.48u
Frank Ammirante
Last 30d: 239-263-10 (-10.0u)
Under 7.5+100
1u

Sean Zerillo
Last 30d: 175-145-12 (+6.1u)
Under 8.5-128
0.64u
Bet to 7.5 (-102)
Cam Is Money
Last 30d: 82-105-3 (-27.7u)
CLE -109
1.09u
Astros vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Astros vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 4-1 in their last 5 games.
- Guardians are 3-2 in their last 5 games against the spread
- Guardians are 15-15 in their road games against the spread
- The totals have gone OVER in 0 of Guardians' last 5 games
- The totals have gone OVER in 12 of Guardians' 25 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Astros Injury Updates

Guardians Injuries

Astros Injuries
- Lance McCullersSP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out
Astros vs. Guardians Box Score
Astros Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 96 | 5 | 3 | 2 | |
![]() | 15 | 1 | 0 | 0 | |
![]() | 15 | 1 | 1 | 0 | |
![]() | 39 | 2 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 3-5 | 1 | 0 | 2 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 0-5 | 0 | 0 | 0 |
![]() | 3-5 | 3 | 1 | 2 |
![]() | 3-5 | 2 | 2 | 2 |
![]() | 1-1 | 0 | 0 | 0 |
![]() | 0-2 | 1 | 0 | 1 |
![]() | 0-2 | 1 | 0 | 1 |
![]() | 1-4 | 0 | 0 | 1 |
![]() | 0-3 | 1 | 0 | 0 |
![]() | 0-3 | 1 | 0 | 0 |
![]() | 1-3 | 1 | 0 | 1 |
![]() | 1-3 | 1 | 0 | 1 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 94 | 5 | 2 | 6 | |
![]() | 22 | 2 | 1 | 1 | |
![]() | 19 | 1 | 0 | 0 | |
![]() | 19 | 1 | 1 | 1 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 1-4 | 2 | 0 | 0 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 2-4 | 0 | 0 | 1 |
![]() | 1-3 | 0 | 0 | 1 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 3-3 | 0 | 0 | 0 |
Astros vs. Guardians Odds Comparison
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Astros at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
Astros 23-31 | N/A | N/A |
Guardians 32-23 | N/A | N/A |





























