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Guardians vs. Cardinals Odds & Betting Predictions - April 15, 2026

Guardians at Cardinals

5:15 pm • CARD

Cleveland Guardians

32-23
3
3 - 5

St. Louis Cardinals

29-22
5
Starting Pitchers
pitcherteameraw-l
Dustin May logoD.MaySt. Louis Cardinals logo5.003-5
Slade Cecconi logoS.CecconiCleveland Guardians logo5.183-5

Guardians at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
32-23
-1.5
PK-116
o9-111
-112
Cardinals
29-22
u8.5
PK-261
u9-106
-111
location pinWednesday 5:15 p.m.
April 15, 2026
Busch StadiumSt. Louis
Guardians vs. Cardinals Expert Picks
Player Prop Savant
Player Prop Savant
Last 30d: 156-138-3 (+13.2u)
Over 5.5 (Live)-119
1u
Alex Hinton
Alex Hinton
Last 30d: 73-123-2 (-18.9u)
J.Walker o1.5 Total Bases (Live)+105
1.05u
Picks Office
Picks Office
Last 30d: 155-155-12 (-9.2u)
STL -105
0.95u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Billy Ward
Billy Ward
Last 30d: 30-34-0 (+0.7u)
Under 0.5 (1st Inn)-110
1.1u
Not much room here, would play to -115
Frank Ammirante
Frank Ammirante
Last 30d: 239-263-10 (-10.0u)
Over 4.5 (F5)-120
1.2u
Michael McGreevy u1.5 BB+130
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 104-109-2 (-11.5u)
CLE -104
1.04u
Nick Martin
Nick Martin
Last 30d: 27-45-0 (-5.3u)
Over 8.5-105
0.5u
Cam Is Money
Cam Is Money
Last 30d: 82-105-3 (-27.7u)
CLE +100
1u

Guardians vs. Cardinals Previews & Analysis

  • Zerillo's Opening Pitch for Wednesday article feature image

    Zerillo's Opening Pitch for Wednesday

    Sean Zerillo•
    Apr 16, 2026 UTC
  • 3 MLB Player Props for Wednesday article feature image

    3 MLB Player Props for Wednesday

    Alex Hinton•
    Apr 15, 2026 UTC
  • Guardians vs Cardinals: Over/Under Pick for Wednesday Night article feature image

    Guardians vs Cardinals: Over/Under Pick for Wednesday Night

    Nick Martin•
    Apr 15, 2026 UTC
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Prop Odds Comparison

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No props found

Line Movement Tracker

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Guardians vs. Cardinals Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Cardinals

61%

Bets%

39%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cardinals are 2-3 in their last 5 games.
  • Cardinals are 2-3 in their last 5 games against the spread
  • Cardinals are 16-9 in their road games against the spread
  • The totals have gone OVER in 3 of Cardinals' last 5 games
  • The totals have gone OVER in 13 of Cardinals' 26 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		31-2015-1116-93-328-17
Guardians		31-2416-915-1517-1414-10

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		23-25-313-12-110-13-22-421-21-3
Guardians		26-2912-1314-1615-1611-13

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		29-2213-1316-93-326-19
Guardians		32-2315-1017-1319-1213-11

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 14thCLEW 6-5+1.5 WO 9STL +109
Apr 13thCLEL 3-9+1.5 LO 8CLE +100
Apr 12thBOSL 3-9+1.5 LO 9BOS +105
Apr 11thBOSL 1-7+1.5 LO 7.5BOS +118
Apr 11thBOSW 3-2+1.5 WU 7.5STL +115

Guardians vs. Cardinals Injury Updates

Guardians Injuries

    Cardinals Injuries

    • Lars Nootbaar
      LF

      Nootbaar is out with heel

      Out

    See more MLB Injuries Right Arrow
    Guardians vs. Cardinals Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Slade Cecconi logoRS.Cecconi, P87441
    Connor Brogdon logoRC.Brogdon, P181.103
    Tim Herrin logoLT.Herrin, P80.100
    Matt Festa logoRM.Festa, P362.131
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, CF1-4000
    Chase DeLauter logo2C.DeLauter, RF0-3000
    Jose Ramirez logo3J.Ramirez, DH0-4100
    Kyle Manzardo logo4K.Manzardo, 1B2-2001
    Angel Martinez logo4A.Martinez, PH0-2000
    Angel Martinez logo4A.Martinez, LF0-2000
    George Valera logo5G.Valera, LF1-2000
    Rhys Hoskins logo5R.Hoskins, PH0-1100
    Rhys Hoskins logo5R.Hoskins, 1B0-1100
    Juan Brito logo6J.Brito, 2B0-4000
    Daniel Schneemann logo7D.Schneemann, 3B2-3100
    Bo Naylor logo8B.Naylor, C1-3002
    Brayan Rocchio logo9B.Rocchio, SS1-3000
    Cardinals Player Stats
    Projected
    PITCHERPCIPKER
    Dustin May logoRD.May, P91641
    Justin Bruihl logoLJ.Bruihl, P240.212
    JoJo Romero logoLJ.Romero, P171.110
    Riley O'Brien logoRR.O'Brien, P15120
    HITTERSH-ABRHRRBI
    JJ Wetherholt logo1J.Wetherholt, 2B0-1001
    Ivan Herrera logo2I.Herrera, DH0-2000
    Alec Burleson logo3A.Burleson, 1B2-5002
    Jordan Walker logo4J.Walker, RF1-5000
    Nolan Gorman logo5N.Gorman, 3B1-4000
    Ramon Urias logo5R.Urias, PR0-1100
    Ramon Urias logo5R.Urias, 3B0-1100
    Masyn Winn logo6M.Winn, SS1-4100
    Nathan Church logo7N.Church, LF3-4201
    Pedro Pages logo8P.Pages, C1-3001
    Victor Scott logo9V.Scott, CF0-2100

    Guardians vs. Cardinals Odds Comparison

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    Guardians at Cardinals Team Totals

    MatchupOverUnder
    Guardians
    32-23
    N/A
    N/A
    Cardinals
    29-22
    N/A
    N/A