Giants vs. Cardinals Odds & Betting Predictions - September 6, 2025

Giants at Cardinals

12:15 am • FDSMW
8 - 2
Starting Pitchers
pitcherteameraw-l
Michael McGreevy logoM.McGreevySt. Louis Cardinals logo4.176-2
Carson Seymour logoC.SeymourSan Francisco Giants logo4.740-2

Giants at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Giants
72-69
-1.5
-1.5+158
o8.5-108
-102
Cardinals
70-72
u7.5
+1.5-192
u8.5-118
-122
location pinSaturday 12:15 a.m.
September 06, 2025
Busch StadiumSt. Louis
Giants vs. Cardinals Expert Picks
Picks Office
Picks Office
Last 30d: 76-71-5 (+3.2u)
Over 8-115
0.87u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 36-43-2 (+1.7u)
Moneyline Hacks
Moneyline Hacks
Last 30d: 91-84-5 (+18.8u)
C.Seymour u3.5 Ks+100
1u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/A8v49URQaG 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise Link to VIP (Copy &Paste): https://linktr.ee/moneylinehacks%F0%9F%94%A560% OFF with promo code: Hacks60
Sean Zerillo
Sean Zerillo
Last 30d: 177-176-5 (+5.3u)
Under 8.5-115
0.58u
Bet to 8 (-105)
STL -108
0.54u
Bet to -115

Prop Odds Comparison

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No props found

Line Movement Tracker

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Giants vs. Cardinals Public Betting Percentages

Away Logo

Giants

Public

49%

Bets%

51%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals
71-7136-3735-3425-3945-32
Giants
65-7629-4036-3631-5133-24

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals
72-63-737-33-335-30-432-27-539-36-2
Giants
66-70-528-40-138-30-430-51-134-19-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals
70-7239-3431-3832-3237-40
Giants
72-6935-3437-3544-3827-30

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 3rdATHW 5-1+1.5 WU 8.5STL -111
Sep 2ndATHW 2-1+1.5 WU 8.5STL -108
Sep 1stATHL 3-11-1.5 LO 7.5ATH -158
Aug 31st@CINL 4-7+1.5 LO 8.5CIN +116
Aug 30th@CINW 4-2+1.5 WU 8STL +123

Cardinals vs. Giants Injury Updates

Cardinals Injuries

  • Nolan Arenado
    3B

    Arenado is out with shoulder

    Out

  • Brendan Donovan
    2B

    Donovan is out with groin

    Out

Giants Injuries

  • Tom Murphy
    C

    Murphy is out with back

    Out

  • JT Brubaker
    RP

    Brubaker is out with ribs

    Out

Giants vs. Cardinals Box Score
Giants Player Stats
Projected
PITCHERPCIPKER
Carson Seymour logoRC.Seymour, P75521
Matt Gage logoLM.Gage, P15120
Tristan Beck logoRT.Beck, P42331
HITTERSH-ABRHRRBI
Heliot Ramos logo1H.Ramos, LF2-6100
Rafael Devers logo2R.Devers, DH2-4112
Willy Adames logo3W.Adames, SS1-5112
Dominic Smith logo4D.Smith, 1B2-5000
Matt Chapman logo5M.Chapman, 3B1-4100
Jung Hoo Lee logo6J.Lee, CF4-5201
Casey Schmitt logo7C.Schmitt, 2B2-5101
Drew Gilbert logo8D.Gilbert, RF1-3001
Patrick Bailey logo9P.Bailey, C3-5101
Cardinals Player Stats
Projected
PITCHERPCIPKER
Michael McGreevy logoRM.McGreevy, P75436
Gordon Graceffo logoRG.Graceffo, P30210
Ryan Fernandez logoRR.Fernandez, P22102
Chris Roycroft logoRC.Roycroft, P22130
Andre Granillo logoRA.Granillo, P15120
HITTERSH-ABRHRRBI
Lars Nootbaar logo1L.Nootbaar, LF0-4000
Ivan Herrera logo2I.Herrera, DH1-4111
Nolan Gorman logo3N.Gorman, 1B1-4000
Masyn Winn logo4M.Winn, SS0-3000
Garrett Hampson logo4G.Hampson, PH0-1000
Garrett Hampson logo4G.Hampson, SS0-1000
Jimmy Crooks logo5J.Crooks, C1-4100
Thomas Saggese logo6T.Saggese, 3B1-3000
Jordan Walker logo7J.Walker, RF0-4000
Victor Scott logo8V.Scott, CF1-2001
Jose Fermin logo9J.Fermin, 2B0-3000

Giants vs. Cardinals Odds Comparison

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Giants at Cardinals Team Totals

MatchupOverUnder
Giants
72-69
N/A
N/A
Cardinals
70-72
N/A
N/A