St. Louis Cardinals Odds

St. Louis Cardinals 2026 Season Preview

The Cardinals have officially embraced a "Youth Movement 2.0" in 2026 after the departures of franchise icons Sonny Gray, Willson Contreras, and Nolan Arenado. The new-look roster is a lottery ticket approach, banking on Lars Nootbaar’s recovery from heel surgery and the raw power of minor league signing Nelson Velázquez. While the rotation is a patchwork unit led by Kyle Gibson and Matthew Liberatore, the front office is focusing on evaluating a core that includes JJ Wetherholt and Thomas Saggese. Projected for a sub-.500 finish, the 2026 season in St. Louis isn't about the division title, but about determining which of their numerous young infielders will be the faces of the next competitive Cardinals window.

Find St. Louis Cardinals MLB odds for moneylines, spreads, totals and more on this page.

Betting on the St. Louis Cardinals

Check out below the betting options:

Cardinals Spread (Run Line)

When betting on baseball, you’ll be faced with three standard options: the moneyline, over/under and run line.

The run line is a bet on the margin of victory, like a point spread. But because baseball is low scoring, the spread will almost always be -1.5 for the favorite and +1.5 for the underdog. The payouts for each will just be adjusted based on each team’s strength.

Here’s a brief example of a run line for a hypothetical Cardinals game:

• Los Angeles Angels (+1.5) 
• St. Louis Cardinals (-1.5)

As shown above, the Cardinals are favored by 1.5 runs against the Angels; the minus sign (-) indicates St. Louis is the favorite, while a plus sign (+) is used to denote the underdog. Bettors who wanted to back St. Louis here would be “laying” those 1.5 runs, meaning for their bets to cash the Cardinals would need to win by two runs or more. Bettors who selected the Angels +1.5 would win if Los Angeles won outright or kept a loss to 1 run.

Cardinals Moneylines

Many first time bettors are wary of run line bets, especially when riding with the hometown team. In that case, moneyline wagers are often seen as the safer way to go. A moneyline bet is a bet on who wins the game -- no run line involved.

Let’s use the same example from before to understand the moneyline better:

• Los Angeles Angels +150
• St. Louis Cardinals -180

Just as with run lines, the minus sign (-) signifies a team is favored, while the plus sign (+) means a team is the underdog. The moneyline odds, written in American odds format here, indicate how big or small a favorite that team is, written in increments of $100. For example, to win $100 on the Cardinals, a bettor would need to risk $180. On the flip side, a $100 bet on the Angels would net $150 if they pulled the upset.

Odds can differ from sportsbook to sportsbook, so always make sure you shop for the best line with The Action Network app.

Cardinals Over/Unders

Betting on a team to win or cover a run line isn’t the only type of wager allowed on MLB games. Almost all sportsbooks will offer a total on the game, also known as an over/under. This bet is not on the winner of the contest, but on the number of runs the two teams will combine to score; sportsbooks hang a number, and bettors can wager either over or under that total.

If the number for our hypothetical Cardinals-Angels matchup was 8 runs, over bettors would require 9 points or more to cash their tickets, while those who bet the under would need 7 or fewer runs. If the two teams scored exactly 8 runs between them, that bet would push and all wagers would be refunded.

Cardinals Props

Some bettors find more entertainment and success betting on more specific outcomes than the result of the game. Prop bets cover a wide market of wagers on player stats, discrete in-game events, and any style of yes/no question. Many props are bets on specific players and their performance, such as betting Nolan Gorman over 1.5 hits on a given night, or betting that Michael McGreevy will strike out over 9.5 batters. Some props can be shorter term, such as betting on the number of runs scored in the first five innings or who will hit a home run. Offerings tend to vary depending on the sportsbook, so use our best sportsbooks review to find the best bet f or you.

Cardinals Futures

Bettors should shop for the best line to get good odds on Cardinals MLB utures bets. Futures are bets that focus on long term outcomes, like the Cardinals to win the NL Central, win the National League Pennant, win the World Series, or even individual awards like winning league MVP.

How to Bet on the St. Louis Cardinals

Missouri sports betting is now legal, allowing St. Louis Cardinals fans to place bets on their favorite team.

The Cardinals also see betting action across the country, so if you're interested in wagering on this team, consider using the BetMGM Bonus Code to maximize your bets.

Underdog Promo Code

If you're looking for a different type of action, Underdog is a great option for daily fantasy sports. Underdog is among the most simple and exciting DFS games in North America because users just have to choose over/under stats for a chance to win cash. New users can sign up using our Underdog Promo Code now!

Kalshi Promo Code

The Kalshi promo code is available in most states and is a great way for users to get in on St. Louis Cardinals action without turning to sportsbooks or DFS apps. This federally regulated exchange offers contract trading on event outcomes, including Cardinals games, player props, etc.