76ers vs. Celtics Odds & Betting Predictions - October 22, 2025

76ers at Celtics

11:30 pm • NBCS-BOS

Philadelphia 76ers

10-9

117

117 - 116

Boston Celtics

11-9

116

MatchupOpenSpreadTotalMoneyline
76ers 10-9	+2.5	+5.5-112	o230.5-108	+166
Celtics 11-9	u225	-5.5-109	u230.5-112	-198

Wednesday 11:30 p.m.

October 22, 2025

TD GardenBoston

Over 229.5-105

1.9u

J.Embiid u33.5 Pts+Rebs-110

0.45u

BOS -4.5-110

3.5

Under 228.5-110

X: PicksOffice

PHI +4.5-110

0.91u

S.Hauser o9.5 Pts-108

J.Embiid Double-Double (Yes)+122

📚Player Profit 🔑 J.Embiid Double-Double +122 (Player Profit) 2u You will not get better odds ROS than this. He may not play 30+ minutes but he can do this in 15 minutes. He almost had a trip dub the last preseason game in 14 minutes…i love this one Code: sirlocks for 10% off when you get funded at https://www.playerprofit.com/

Over 229-105

0.95u

Awfully high for this matchup plus no Tatum

PHI +160

3.2u

📚Player Profit 🔑 Sixers ML +160 (Player Profit) 2u If you didn’t think this was coming, idek what to tell you. I’m not sure i should get my hopes up too much but they are at peak level rn. Embiid looks great and back in shape, Maxey is stud, VJ gonna be a stud, Grimes is a bucket, Oubre is a vibe…just feels like it’s all coming together. Best odds we will get all year, jump on it. Code: sirlocks for 10% off when you get funded at https://www.playerprofit.com/

J.Embiid o33.5 Pts+Rebs-110

0.25u

Tailing @ChicagoFlow

J.Embiid o4.5 Ast-129

J.Embiid o34.5 Pts+Rebs-114

0.75u

@ChicagoFlow ⭐️⭐️ https://myaction.app/e5jJG5lYFXb

J.Embiid o33.5 Pts+Rebs-125

0.45u

NBA Best Bets: 2 Picks for the Late Slate
Action Network Staff•
Oct 22, 2025 UTC
76ers vs Celtics Parlay: +253 SGP for Tonight
Chilly Bets•
Oct 22, 2025 UTC

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NBA Public Betting

Celtics are 3-2 in their last 5 games.
Celtics are 4-1 in their last 5 games against the spread
Celtics are 5-5 in their road games against the spread
The totals have gone OVER in 2 of Celtics' last 5 games
The totals have gone OVER in 5 of Celtics' 10 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Celtics	10-10	5-5	5-5	5-6	5-4
76ers	11-7-1	5-6	6-1-1	5-3	6-4-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Celtics	8-12	5-5	3-7	4-7	4-5
76ers	11-8	6-5	5-3	6-2	5-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Celtics	11-9	N/A	N/A	7-4	4-5
76ers	10-9	N/A	N/A	7-1	3-8

date	opponent	score	spread	over/under	moneyline
Oct 15th	TOR	W 110-108	-5 L	U 232	BOS -170
Oct 12th	CLE	W 138-107	-7.5 W	O 231.5	BOS -285
Oct 10th	@TOR	L 105-107	-2.5 L	U 229	TOR -148
Oct 9th	@MEM	W 121-103	-4 W	U 232	BOS -160
Jul 20th	ATL	W 101-80	+1 W	U 185.5	BOS -105

Jayson Tatum
PF
Tatum is out with achilles
Out
Neemias Queta
C
Neemias Queta (injury management) out Sunday.
Out

Kelly Oubre
SF
Oubre is out with knee
Out

Quentin Grimes
SG
Quentin Grimes (calf) has been downgraded to questionable Tuesday.
Questionable
VJ Edgecombe
PG
Edgecombe is questionable with calf
Questionable