Duke vs. Houston Sweet 16 Odds
| Duke Spread | +4 |
| Houston Spread | -4 |
| Over/Under | 134.5 |
| Date | Friday, March 29 |
| Time | 9:39 p.m. ET |
| Channel | CBS |
*Duke vs. Houston odds as of Thursday night
Duke finds itself in an interesting spot heading into Friday night's Sweet 16 matchup.
The latest Duke vs. Houston spread shows the Blue Devils as 4-point underdogs, which may be a surprise for some college basketball bettors.
In addition, 59% of spread tickets are laying the points with the Cougars thus far. So while the action is fairly balanced, it's not like bettors are falling over themselves to take Duke and the points in the Sweet 16.
However, while bettors may be split on the Duke vs. Houston spread, the Action Network's College Basketball PRO Projections are not.
Below we take a detailed look at our betting model prediction for this game, which is the biggest spread edge (by far) of Friday's NCAA Tournament Sweet 16 slate.
Duke vs. Houston Spread Pick
Should bettors pounce on the Blue Devils as 'dogs?
