USC vs. Notre Dame Odds & Betting Predictions - October 18, 2025

USC at Notre Dame

11:30 pm • NBC

USC Trojans

@

Notre Dame Fighting Irish

MatchupOpenSpreadTotalMoneyline
USC 5-1	+10.5	+9.5-110	o61.5-110	+270
Notre Dame 4-2	u53.5	-9.5-110	u61.5-110	-345

location pin

Saturday 11:30 p.m.

October 18, 2025

Notre Dame StadiumSouth Bend

thermometer image

64°Fahrenheit

rain image

30%Rain

wind image

8Wind

No props found

NCAAF Public Betting

Notre Dame are 3-2 in their last 5 games.
Notre Dame are 3-2 in their last 5 games against the spread
Notre Dame are 1-1 in their road games against the spread
The totals have gone OVER in 4 of Notre Dame' last 5 games
The totals have gone OVER in 2 of Notre Dame' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Notre Dame	3-3	2-2	1-1	3-3	N/A
USC	3-3	3-1	0-2	3-3	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Notre Dame	4-2	2-2	2-0	4-2	N/A
USC	4-2	3-1	1-1	4-2	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Notre Dame	4-2	N/A	N/A	4-2	N/A
USC	5-1	N/A	N/A	5-1	N/A

date	opponent	score	spread	over/under	moneyline
Oct 11th	NCST	W 36-7	-23.5 W	U 59.5	ND -2400
Oct 4th	BOISE	W 28-7	-21.5 L	U 63	ND -1600
Sep 27th	@ARK	W 56-13	-5.5 W	O 63.5	ND -218
Sep 20th	PUR	W 56-30	-24.5 W	O 51	ND -4000
Sep 13th	TA&M	L 40-41	-6.5 L	O 49.5	TA&M -250

Total

Passing

1955

YDS

1757

136/186

Comps/Atts

114/169

10.51

YPA

10.4

14/2

TDs/INTs

13/3

4/28

Sacks/Yards

9/74

Rushing

1359

Rush Yards

1036

213

Attempts

220

6.38

YPC

4.71

19

TDs

17

Turnovers

Fumbles Lost

2

Interceptions

3

Efficiency

31/33 93.9%

Redzone

24/29 82.8%

37/67 0%

3rd Down

33/67 0%

10/12 0%

4th Down

5/14 0%

First Downs

157

Total

143

85

Pass

78

60

Rush

52

12

Penalty

13

Misc

/

Penalties/Yards

/

Could not load odds

See more NCAAF Odds

MatchupOverUnder
USC 5-1	N/A	N/A
Notre Dame 4-2	N/A	N/A