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USC vs. Oregon Odds & Betting Predictions - November 22, 2025

USC at Oregon

8:30 pm • CBS

USC Trojans

9-3
27
27 - 42

Oregon Ducks

11-1
42

USC at Oregon Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
USC
9-3
+9.5
+10.5-112
o59.5-102
+320
Oregon
11-1
u55.5
-10.5-110
u59.5-110
-410
location pinSaturday 8:30 p.m.
November 22, 2025
Autzen StadiumEugene
USC vs. Oregon Expert Picks
Player Prop Savant
Player Prop Savant
Last 30d: 51-49-0 (-4.9u)
Under 72.5 (Live)-110
1u
Duck
Duck
Last 30d: 213-164-4 (+23.1u)
USC +8.5 (Live)-106
1.06u
Cam Is Money
Cam Is Money
Last 30d: 129-118-3 (+0.9u)
ORE -220 (Live)
1.14u
Sandy Plashkes
Sandy Plashkes
Last 30d: 115-139-6 (-32.2u)
Over 58.5-110
1.5u
Mjaybrod
Mjaybrod
Last 30d: 114-110-2 (+4.4u)
ORE -10.5-106
1.89u
CFB POD
Vegas Refund
Vegas Refund
Last 30d: 34-40-1 (-9.8u)
USC +10.5-107
1.07u
YBK Picks.com
Last 30d: 37-31-1 (+7.4u)
USC +10.5-105
2u
Roger Goodell
Roger Goodell
Last 30d: 43-53-1 (-7.0u)
USC +11-110
0.5u
Sean Zerillo
Sean Zerillo
Last 30d: 72-54-1 (+5.2u)
ORE -10-113
0.25u
💰🦡 Jake
💰🦡 Jake
Last 30d: 97-111-2 (-5.7u)
ORE -6.5 (1H)-105
1.5u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 57-66-1 (-9.4u)
ORE o34.5-120
0.83u
@_Collin1 https://myaction.app/froqdThRtYb
J.Davison 2+ TDs Yes+300
0.25u
@_Collin1 https://myaction.app/froqdThRtYb
ORE -9.5-112
0.89u
@_Collin1 https://myaction.app/froqdThRtYb
Collin Wilson
Collin Wilson
Last 30d: 88-71-1 (+7.1u)
ORE -9.5-110
1u
From BBOC Podcast
J.Davison 2+ TDs Yes+310
0.32u
From Action Network writeup
ORE o34.5-120
0.5u
From Action Network writeup
Babs .
Babs .
Last 30d: 125-91-1 (+20.4u)
ORE -9.5-112
0.89u
Anders
Anders
Last 30d: 19-12-0 (+7.1u)
USC +10.5-110
2.2u
Completely disagree with the Oregon money here. Gonna buy this back above 10. USC was getting this same number at ND in a game where they still covered in despite turning the ball over 3 times. That’s with market inflation of Riley being bad outside the west coast as well. Have ND graded above Oregon and on the surface not the best matchup in the world but think Oregon has benefited from schedule a bit in terms of passing defense numbers. However Oregon’s pass rush is not elite by any means, being graded out in the bottom half of the Big Ten, and that’s how u beat Maiava(133.1 Passer Rating when Clean compared to just a 42.8 when pressured). Don’t think Oregon will be able to exploit Maiava crumbling under pressure enough. Had this spot circled as this is USC’s Super Bowl with 2 losses. Also fwiw lookahead at FD just a week ago was sitting at Oregon -6.5, i know that market isn’t as efficient but this line going up to 10.5 for basically no reason is just too much love to an Oregon team that has underwhelmed us in all 3 big games they’ve played

USC vs. Oregon Previews & Analysis

  • Our Staff Picks for #15 USC vs. #7 Oregon article feature image

    Our Staff Picks for #15 USC vs. #7 Oregon

    Action Network Staff•
    Nov 22, 2025 UTC
  • USC vs. Oregon: 2 Bets for Big Ten Battle article feature image

    USC vs. Oregon: 2 Bets for Big Ten Battle

    Collin Wilson•
    Nov 22, 2025 UTC
  • Your Week 13 NCAAF Betting Cheat Sheet article feature image

    Your Week 13 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Nov 22, 2025 UTC
  • Our NCAAF Player Props for Week 13 article feature image

    Our NCAAF Player Props for Week 13

    Doug Ziefel•
    Nov 22, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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USC vs. Oregon Public Betting Percentages

Away Logo

USC

Public

Home Logo

Oregon

48%

Bets%

52%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Oregon are 4-1 in their last 5 games.
  • Oregon are 3-2 in their last 5 games against the spread
  • Oregon are 3-2 in their road games against the spread
  • The totals have gone OVER in 1 of Oregon' last 5 games
  • The totals have gone OVER in 4 of Oregon' 7 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Oregon		8-45-23-26-31-0
USC		5-74-31-44-61-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Oregon		6-64-32-35-41-0
USC		6-64-32-35-51-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Oregon		11-1N/AN/A8-11-0
USC		9-3N/AN/A9-10-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 15thMINNW 42-13-26.5 WO 46.5ORE -3200
Nov 8th@IOWAW 18-16-4.5 LU 41.5ORE -210
Oct 25thWISW 21-7-31.5 LU 44.5-
Oct 18th@RUTW 56-10-18 WO 62ORE -1048
Oct 11thIUL 20-30-6.5 LU 51.5IU -278
Team Stats

Total

382
Total Yards
436
72
Total Plays
71
5.305555555555555
Yards Per Play
6.140845070422535

Passing

330
YDS
257
26/44
Comps/Atts
22/30
7.5
YPA
8.566666666666666
4/2
TDs/INTs
2/1
1/9
Sacks/Yards
0/0

Rushing

52
Rush Yards
179
28
Attempts
41
1.8571428571428572
YPC
4.365853658536586
0
TDs
3

Turnovers

0
Fumbles Lost
0
2
Interceptions
1

Efficiency

3/4 75%
Redzone
4/4 100%
7/15 0%
3rd Down
7/12 0%
2/4 0%
4th Down
0/1 0%

First Downs

23
Total
26
17
Pass
12
2
Rush
9
4
Penalty
5

Misc

8/103
Penalties/Yards
11/130

USC vs. Oregon Odds Comparison

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See more NCAAF Odds Right Arrow

USC at Oregon Team Totals

MatchupOverUnder
USC
9-3
o23.5-125
u23.5-105
Oregon
11-1
o34.5-125
u34.5-105