USC vs. Oregon Odds & Betting Predictions - November 22, 2025

USC at Oregon

8:30 pm • CBS

USC Trojans

@

Oregon Ducks

MatchupOpenSpreadTotalMoneyline
USC 8-2	+12.5	+9.5-107	o55.5-110	+330
Oregon 9-1	u55.5	-9.5-112	u55.5-110	-430

location pin

Saturday 8:30 p.m.

November 22, 2025

Autzen StadiumEugene

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53°Fahrenheit

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23%Rain

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7Wind

No props found

NCAAF Public Betting

Oregon are 4-1 in their last 5 games.
Oregon are 3-2 in their last 5 games against the spread
Oregon are 2-2 in their road games against the spread
The totals have gone OVER in 2 of Oregon' last 5 games
The totals have gone OVER in 3 of Oregon' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Oregon	6-4	4-2	2-2	4-3	1-0
USC	5-5	4-2	1-3	4-5	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Oregon	5-5	3-3	2-2	4-3	1-0
USC	5-5	4-2	1-3	5-4	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Oregon	9-1	N/A	N/A	6-1	1-0
USC	8-2	N/A	N/A	8-1	0-1

date	opponent	score	spread	over/under	moneyline
Nov 15th	MINN	W 42-13	-26.5 W	O 46.5	ORE -3200
Nov 8th	@IOWA	W 18-16	-4.5 L	U 41.5	ORE -210
Oct 25th	WIS	W 21-7	-31.5 L	U 44.5	-
Oct 18th	@RUT	W 56-10	-18 W	O 62	ORE -1048
Oct 11th	IU	L 20-30	-6.5 L	U 51.5	IU -278

Total

Passing

2727

YDS

2418

192/285

Comps/Atts

201/277

9.57

YPA

8.73

18/6

TDs/INTs

22/5

10/67

Sacks/Yards

12/84

Rushing

1802

Rush Yards

2336

310

Attempts

369

5.81

YPC

6.33

24

TDs

26

Turnovers

Fumbles Lost

6

Interceptions

5

Efficiency

42/45 93.3%

Redzone

36/41 87.8%

55/106 0%

3rd Down

59/120 0%

12/17 0%

4th Down

12/18 0%

First Downs

224

Total

231

117

Pass

105

85

Rush

115

22

Penalty

11

Misc

/

Penalties/Yards

/

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See more NCAAF Odds

MatchupOverUnder
USC 8-2	N/A	N/A
Oregon 9-1	N/A	N/A