Cavaliers vs. Cardinals Odds & Betting Predictions - October 4, 2025
Cavaliers at Cardinals
7:30 pm • ESPN2Cavaliers at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Cavaliers 11-3 | +7.5 | +6.5-110 | o60-110 | +195 |
Cardinals 9-4 | u59.5 | -6.5-115 | u60-110 | -245 |

L&N Federal Credit Union StadiumLouisville
Cavaliers vs. Cardinals Expert Picks
Mjaybrod
Last 30d: 61-44-1 (+14.0u)
LOU +220 (Live)
0.5u
Fuck!
Cam Is Money
Last 30d: 45-41-0 (-0.3u)
LOU o33.5 Team Total-125
1u
Collin Wilson
Last 30d: 0-0-0 (+0.0u)
Over 58.5-133
0.67u
Alternate Number at DK
Allan Lem
Last 30d: 105-73-5 (+10.0u)
LOU -6.5-110
0.55u
Tailing @Bet_Labs

Sean Zerillo
Last 30d: 39-49-0 (-0.3u)
LOU -6.5-105
0.26u
Bet Labs
Last 30d: 16-10-0 (+5.0u)
LOU -6.5-115
1.73u
Brian Bitler
Last 30d: 85-82-1 (-9.3u)
LOU -6.5-110
3u
Vegas Refund
Last 30d: 70-65-0 (-1.1u)
LOU -6.5-110
1.1u
💰🦡 Jake
Last 30d: 91-96-1 (+7.0u)
LOU -6.5-110
1.1u
Mjaybrod
Last 30d: 61-44-1 (+14.0u)
LOU -6.5-110
1u
Red birds take a dookie
Doug Ziefel
Last 30d: 138-153-2 (-9.5u)
C.Morris u267.5 Pass Yds-115
0.5u
Brandon Kravitz
Last 30d: 54-66-3 (-2.1u)
LOU -6.5-115
0.58u
Fading VA after the win of their season.
Boomer Betz
Last 30d: 95-70-5 (+36.3u)
Under 63-110
0.91u
Duck
Last 30d: 77-86-0 (-7.8u)
UVA +7.5-115
1u
Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.
Babs .
Last 30d: 27-26-0 (-1.8u)
LOU -7-110
1u
Boomer Betz
Last 30d: 95-70-5 (+36.3u)
LOU -5.5-110
1u
POD
Cavaliers vs. Cardinals Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Cavaliers vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 3-2 in their last 5 games.
- Cardinals are 2-3 in their last 5 games against the spread
- Cardinals are 3-1 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 4 of Cardinals' 8 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
237
Total Yards
383
63
Total Plays
75
3.761904761904762
Yards Per Play
5.1066666666666665
149
YDS
329
19/31
Comps/Atts
34/48
4.806451612903226
YPA
6.854166666666667
1/0
TDs/INTs
2/1
2/20
Sacks/Yards
5/46
Cavaliers vs. Cardinals Odds Comparison
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Cavaliers at Cardinals Team Totals
MatchupOverUnder | ||
|---|---|---|
Cavaliers 11-3 | N/A | N/A |
Cardinals 9-4 | N/A | N/A |






