The Arizona Cardinals (2-1) host the Seattle Seahawks (2-1) for Thursday Night Football Week 4. Kickoff is set for in 8:15 p.m. ET from State Farm Stadium in Glendale, Ariz. The game will broadcast live on Amazon Prime Video.
Seahawks vs Cardinals odds have the Seahawks as -130 moneyline favorites and Cardinals as +110 underdogs. The game total is 43.5 (-112o / -108u). The Seahawks are 1.5-point favorites on the spread (Seahawks -1.5; -115).
Continue below to find my Seahawks vs Cardinals prediction and Thursday Night Football picks — plus the latest NFL odds, TNF betting trends and more.
Seahawks vs Cardinals Predictions, Odds, Spread, Over/Under
| Seahawks Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-1.5 -115 | 43.5 -112o / -108u | -130 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+1.5 -105 | 43.5 -112o / -108u | +110 |
- Seahawks vs Cardinals Spread: Seahawks -1.5 (-115), Cardinals +1.5 (-105)
- Seahawks vs Cardinals Over/Under: 43.5 (-112o / -108u)
- Seahawks vs Cardinals Moneyline: Seahawks -130, Cardinals +110
Seahawks vs Cardinals Betting Trends
Seahawks Trends
- The Seahawks are 7-0 SU and 6-1 ATS against the Cardinals since the calendar flipped to 2022
- The Seahawks are 4-10 SU and 5-9 ATS on the road in primetime since 2018
Cardinals Trends
- Kyler Murray is 2-8 SU and 3-7 ATS in his career against the Seahawks
- Murray is a shocking 6-24 against the first-half spread against NFC West opposition, including 1-14 1H ATS vs. NFC West in his last 15 starts
Seahawks vs Cardinals Preview, TNF Prediction
Seahawks Betting Preview
Seattle’s offense has looked much different under new offensive coordinator Klint Kubiak and QB Sam Darnold.
The Seahawks are more run-heavy with a -4.5% pass rate over expected, the third-lowest mark in the league (ahead of only the Eagles and Jets). When they do throw, it is highly concentrated to WR Jaxon Smith-Njigba, who leads the league with a 42% target rate and 60% air yards share.
It is a straightforward offense, which could make it easier for Arizona to prepare on a short week.
