Cubs vs. Pirates Odds & Betting Predictions - September 16, 2025

Cubs at Pirates

10:40 pm • SportsNet PT

Chicago Cubs

4

4 - 1

Pittsburgh Pirates

1

pitcher		team	era	w-l
P.Skenes			1.92	10-9
C.Horton			2.70	10-4

MatchupOpenSpreadTotalMoneyline
Cubs 86-64	+1.5	+1.5-209	o6.5-117	+111
Pirates 65-86	u7	-1.5+172	u6.5-105	-131

location pin

Tuesday 10:40 p.m.

September 16, 2025

PNC ParkPittsburgh

Under 0.5 (1st Inn)-170

0.86u

CHC +110

1.1u

Under 6.5+100

1u

CHC +145 (F5)

1.45u

CHC +120

1.2u

@cowhitchurch https://myaction.app/F6GEecjhIWb

P.Skenes u6.5 Ks+115

1.15u

@DerekCarty https://myaction.app/F6GEecjhIWb

PIT -125

3u

CHC +115

0.58u

Bet to +108

Cubs vs Pirates: Workload Could Tip the Balance
Collin Whitchurch•
Sep 16, 2025 UTC
Grants Dinger Tuesday HR Picks!!!
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Sep 16, 2025 UTC

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MLB Public Betting

Pirates are 1-4 in their last 5 games.
Pirates are 2-3 in their last 5 games against the spread
Pirates are 37-38 in their road games against the spread
The totals have gone OVER in 1 of Pirates' last 5 games
The totals have gone OVER in 31 of Pirates' 76 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pirates	82-69	45-31	37-38	18-25	62-43
Cubs	70-80	35-40	35-40	50-58	19-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pirates	58-85-8	31-40-5	27-45-3	16-25-2	40-59-6
Cubs	67-74-9	35-35-5	32-39-4	46-55-7	21-18-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pirates	65-86	42-34	23-52	21-22	43-62
Cubs	86-64	46-29	40-35	68-40	17-24

date	opponent	score	spread	over/under	moneyline
Sep 15th	CHC	L 0-4	+1.5 L	U 8	CHC +102
Sep 14th	@WSH	L 3-4	-1.5 L	U 8.5	WSH -120
Sep 13th	@WSH	W 5-1	-1.5 W	U 9	PIT -115
Sep 12th	@WSH	L 5-6	-1.5 L	O 8.5	WSH -110
Sep 11th	@BAL	L 2-3	+1.5 W	U 8	BAL +105

Johan Oviedo
SP
Oviedo is questionable with elbow
Questionable

Endy Rodriguez
1B
Rodriguez is out with elbow
Out
Jared Jones
SP
Jones is out with elbow
Out

Michael Soroka
SP
Soroka is out with shoulder
Out
Justin Steele
SP
Steele is out for season with elbow
Out for Season

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PITCHER		PC	IP	K	ER
RC.Horton, P		79	5	6	1
LD.Pomeranz, P		15	1	2	0
RA.Kittredge, P		11	1	2	0
LC.Thielbar, P		12	1	0	0
RB.Keller, P		12	1	2	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	3-4	2	1	1
2N.Hoerner, 2B	3-5	0	0	0
3I.Happ, LF	0-2	1	0	1
4M.Ballesteros, DH	2-4	1	0	0
5C.Kelly, C	2-5	0	0	0
6P.Crow-Armstrong, CF	1-4	0	0	2
7D.Swanson, SS	2-4	0	0	0
8W.Castro, RF	0-5	0	0	0
9M.Shaw, 3B	1-4	0	0	0

PITCHER		PC	IP	K	ER
RP.Skenes, P		92	3.2	6	3
LE.Sisk, P		21	1	1	1
RJ.Lawrence, P		17	1.1	1	0
RC.Mlodzinski, P		55	3	5	0

HITTERS	H-AB	R	HR	RBI
1J.Triolo, 3B	0-4	0	0	0
2S.Horwitz, 1B	1-3	1	0	0
3B.Reynolds, DH	0-4	0	0	0
4O.Cruz, CF	1-4	0	0	1
5N.Gonzales, SS	0-4	0	0	0
6J.Suwinski, LF	0-3	0	0	0
7N.Yorke, 2B	0-3	0	0	0
8A.Canario, RF	1-3	0	0	0
9H.Davis, C	1-3	0	0	0

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MatchupOverUnder
Cubs 86-64	N/A	N/A
Pirates 65-86	N/A	N/A