Padres vs. Giants Odds & Betting Predictions - June 5, 2025

Padres at Giants

7:45 pm • SDPA

San Diego Padres

36-26

2 - 3

San Francisco Giants

36-28

pitcher		team	era	w-l
R.Ray			2.44	8-1
D.Cease			4.72	1-5

MatchupOpenSpreadTotalMoneyline
Padres 36-26	+1.5	-1.5+172	o7-110	-104
Giants 36-28	u7.5	+1.5-207	u7-118	-115

Thursday 7:45 p.m.

June 05, 2025

Oracle ParkSan Francisco

SD +220 (Live)

SF -125 (Live)

SDQL SYSTEM (60-44 Record) #YourBestBet

SD -105

Under 3.5 (F5)-102

1.02u

Under 3.5 (F5)+103

0.97u

SD +105

Follow @PicksOffice on X. Padres hunting the sweep – already 2-0 this series, both wins in extras. 7-0 last 7 vs Giants, mental edge locked in. SD's bullpen: 1.83 ERA over last 3 games, 21.1 IP, nails late. Giants stuck scoring ≤2 runs in 6 of last 8 – can’t hit, can’t close, can’t win. Dylan Cease heating up – 6+ Ks in 5 straight starts. Giants hitting just .202 last 10 games, .228 season avg, can’t handle even average arms. Padres bats underwhelming lately (.211 L10) but still 7-3. Oracle Park suppresses scoring – perfect for grinder teams. Padres built for these games – calm, opportunistic, disciplined. Giants 3 straight Ls, pressing for offense. Padres already won the series – now playing loose. Too many bats, too much poise. Giants can’t hang.

SD +100

SF -114 (F5)

Padres vs Giants: 2 Systems Lighting Up for This Play
Action Network Staff•
Jun 5, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Giants are 3-2 in their last 5 games.
Giants are 3-2 in their last 5 games against the spread
Giants are 14-19 in their road games against the spread
The totals have gone OVER in 2 of Giants' last 5 games
The totals have gone OVER in 13 of Giants' 31 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Giants	29-35	15-16	14-19	14-25	14-10
Padres	33-29	18-12	15-17	17-18	16-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Giants	29-34-1	13-18	16-16-1	11-28	17-6-1
Padres	25-35-2	11-18-1	14-17-1	17-17-1	8-18-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Giants	36-28	20-11	16-17	23-16	12-12
Padres	36-26	20-10	16-16	21-14	15-12

date	opponent	score	spread	over/under	moneyline
Jun 5th	SD	W 6-5	+1.5 W	O 7.5	SF -107
Jun 4th	SD	L 2-3	-1.5 L	U 7.5	SD -158
Jun 3rd	SD	L 0-1	-1.5 L	U 7.5	SD -180
Jun 1st	@MIA	W 4-2	-1.5 W	U 8	SF -115
May 31st	@MIA	L 0-1	-1.5 L	U 7.5	MIA -148

Tom Murphy
C
Murphy is out with back
Out

Joe Musgrove
SP
Musgrove is out for season with elbow
Out for Season
Yu Darvish
SP
Darvish is out with elbow
Out
Michael King
SP
Michael King (shoulder) has been scratched Saturday. Sean Reynolds will start for the Padres.
Out
Matt Waldron
SP
Waldron is out with hamstring
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RD.Cease, P	92	5	7	3
RD.Morgan, P	39	2	3	0
LY.Matsui, P	10	1	1	0

HITTERS	H-AB	R	HR	RBI
1F.Tatis, RF	0-4	0	0	0
2L.Arraez, 1B	1-3	1	0	0
2T.Wade, 2B	0-1	0	0	0
3M.Machado, 3B	2-4	1	1	2
4J.Merrill, CF	0-4	0	0	0
5G.Sheets, DH	1-4	0	0	0
6J.Iglesias, SS	2-4	0	0	0
7J.Cronenworth, 2B	0-3	0	0	0
7J.Cronenworth, 1B	0-3	0	0	0
8B.Lockridge, LF	1-3	0	0	0
9M.Maldonado, C	0-3	0	0	0

PITCHER	PC	IP	K	ER
LR.Ray, P	101	7	9	2
RR.Rodriguez, P	15	1	2	0
RC.Doval, P	22	1	1	0

HITTERS	H-AB	R	RBI
1D.Johnson, RF	0-4	0	0
1D.Johnson, LF	0-4	0	0
2H.Ramos, DH	0-2	1	0
3J.Lee, CF	1-2	1	0
4M.Chapman, 3B	2-4	1	0
5W.Adames, SS	0-3	0	1
6D.Smith, 1B	3-4	0	2
7J.Encarnacion, LF	0-4	0	0
7M.Yastrzemski, RF	0-0	0	0
8T.Fitzgerald, 2B	0-3	0	0
9A.Knizner, C	0-3	0	0