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Phillies vs. Cubs Odds & Betting Predictions - April 21, 2026

Phillies at Cubs

11:40 pm • MARQ

Philadelphia Phillies

8-17
4
4 - 7

Chicago Cubs

16-9
7
Starting Pitchers
pitcherteameraw-l
Shota Imanaga logoS.ImanagaChicago Cubs logo2.172-1
Jesus Luzardo logoJ.LuzardoPhiladelphia Phillies logo6.921-3

Phillies at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Phillies
8-17
+1.5
+1.5-178
o8.5-115
+109
Cubs
16-9
u8.5
-1.5+162
u8.5-103
-128
location pinTuesday 11:40 p.m.
April 21, 2026
Wrigley FieldChicago
Phillies vs. Cubs Expert Picks
OldSchool0909
Last 30d: 161-185-0 (+2.4u)
PHI +150 (Live)
1u
Allan Lem
Allan Lem
Last 30d: 57-40-0 (+4.2u)
Under 8.5-102
0.26u
Picks Office
Picks Office
Last 30d: 202-191-9 (-2.4u)
CHC -125
0.8u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Over 8.5-110
0.91u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Scott Rickenbach
Scott Rickenbach
Last 30d: 94-118-4 (-31.4u)
CHC -124
0.81u
Player Prop Savant
Player Prop Savant
Last 30d: 133-97-3 (+22.7u)
J.Luzardo u2.5 Earned Runs-135
1.5u
Frank Ammirante
Frank Ammirante
Last 30d: 287-331-14 (-4.8u)
Over 8.5-115
1u
A.Bregman o0.5 HR+553
0.1u
Over 4.5 (F5)-105
1.05u
Sean Zerillo
Sean Zerillo
Last 30d: 168-165-12 (-9.7u)
PHI +110
0.5u
Bet to +105
Brian Bitler
Brian Bitler
Last 30d: 81-81-1 (-1.6u)
PHI +102
3u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 288-268-10 (+16.2u)
Under 8.5-115
0.31u
#EV Pinny -126 Circa -130 BO -125
Anders
Anders
Last 30d: 13-17-2 (-3.8u)
PHI +105
1u
Ultimate contrarian spot especially with how these teams did against each starter last week but think it’s the time to buy. Shotas stuff is up and has been great but overall i trust Luzardo more as he’s the unluckiest pitcher in baseball at the moment. Decent HR weather should hurt Shota more here, 1.93 HR/9 Last Season vs Luzardos .78 HR/9. Cubs lineup way better vs lefties this year but think those numbers will balance out eventually. Better starter imo and huge bullpen edge(no Duran but Cubs bullpen is actually in shambles rn) at + money. If they get to Shota at all it’s wraps. Gotta buy low on the corpse
Sean Zerillo
Sean Zerillo
Last 30d: 168-165-12 (-9.7u)
Under 8.5-115
0.58u
Bet to 8 (-105)
Matt Trollo
Matt Trollo
Last 30d: 51-54-7 (-4.0u)
Under 8.5-115
0.58u
(FD) See notes on FD - Also, hitter friendly weather, but negative run environment + pitcher leaning umpire.
CHC -118
0.4u
(FD) See notes on F5 (Would play either to -150)
CHC -122 (F5)
0.6u
(FD) Luzardo (2.45 SIERA/3.49 xERA) has pitched better than his 7.94 ERA (.417 BABIP, 41.2 LOB%, 23.1 HR/FB), but Imanaga (up 1.3 mph) has returned to All Star form (2.28/2.55). CHC proj LU 10 pt wRC+ edge v LHP since LY (CHC 125 wRC+ v LHP, PHI 59 as a team this year). CHC one of best defenses in the league (proj. LU +10 FRV already). (Splitting 1u 60/40 because PHI does have the better pen thus far and Palencia on IL).

Phillies vs. Cubs Previews & Analysis

  • Trollo’s 3 Plays for Phillies vs. Cubs article feature image

    Trollo’s 3 Plays for Phillies vs. Cubs

    Matt Trollo•
    Apr 21, 2026 UTC
  • 5 MLB Best Bets for Tuesday article feature image

    5 MLB Best Bets for Tuesday

    Action Network Staff•
    Apr 21, 2026 UTC
  • Trigger's Triple-A Picks For Tuesday article feature image

    Trigger's Triple-A Picks For Tuesday

    Adam Trigger•
    Apr 21, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Phillies vs. Cubs Public Betting Percentages

Away Logo

Phillies

Public

Home Logo

Cubs

19%

Bets%

81%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cubs are 5-0 in their last 5 games.
  • Cubs are 4-1 in their last 5 games against the spread
  • Cubs are 4-5 in their road games against the spread
  • The totals have gone OVER in 3 of Cubs' last 5 games
  • The totals have gone OVER in 9 of Cubs' 16 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs		13-129-74-58-95-3
Phillies		4-212-132-84-160-5

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs		15-109-76-39-86-2
Phillies		13-11-18-6-15-511-8-12-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs		16-911-55-411-65-3
Phillies		8-175-103-78-120-5

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 20thPHIW 5-1+1.5 WU 7.5CHC -114
Apr 19thNYMW 2-1-1.5 LU 8CHC -139
Apr 18thNYMW 4-2+1.5 WU 8.5CHC -118
Apr 17thNYMW 12-4-1.5 WO 10CHC -152
Apr 15th@PHIW 11-2+1.5 WO 9CHC +119

Cubs vs. Phillies Injury Updates

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Phillies Injuries

  • Zack Wheeler
    SP

    Wheeler is out with shoulder

    Out

  • Max Lazar
    RP

    Lazar is out with oblique

    Out

  • Andrew Painter
    SP

    Andrew Painter was seen walking out to bullpen, he won't start but could be available in relief.

    Questionable

  • Steward Berroa
    RF

    Berroa is out with shoulder

    Out

See more MLB Injuries Right Arrow
Phillies vs. Cubs Box Score
Phillies Player Stats
Projected
PITCHERPCIPKER
Jesus Luzardo logoLJ.Luzardo, P1004.231
Orion Kerkering logoRO.Kerkering, P150.100
Tanner Banks logoLT.Banks, P30112
Tim Mayza logoLT.Mayza, P23113
Jose Alvarado logoLJ.Alvarado, P230.111
Brad Keller logoRB.Keller, P30.200
HITTERSH-ABRHRRBI
Trea Turner logo1T.Turner, SS0-4000
Kyle Schwarber logo2K.Schwarber, DH1-3211
Bryce Harper logo3B.Harper, 1B1-4112
Felix Reyes logo4F.Reyes, LF1-4000
Adolis Garcia logo5A.Garcia, RF1-4100
J.T. Realmuto logo6J.Realmuto, C0-4000
Alec Bohm logo7A.Bohm, 3B0-3001
Brandon Marsh logo8B.Marsh, CF2-4000
Edmundo Sosa logo9E.Sosa, 2B0-4000
Cubs Player Stats
Projected
PITCHERPCIPKER
Shota Imanaga logoLS.Imanaga, P87711
Riley Martin logoLR.Martin, P17122
Jacob Webb logoRJ.Webb, P70.100
Caleb Thielbar logoLC.Thielbar, P60.200
HITTERSH-ABRHRRBI
Nico Hoerner logo1N.Hoerner, 2B2-5211
Alex Bregman logo2A.Bregman, DH1-4100
Ian Happ logo3I.Happ, LF1-4200
Seiya Suzuki logo4S.Suzuki, RF2-4112
Carson Kelly logo5C.Kelly, C1-4000
Michael Busch logo6M.Busch, 1B1-4102
Dansby Swanson logo7D.Swanson, SS0-2000
Matt Shaw logo8M.Shaw, 3B1-2000
Moises Ballesteros logo8M.Ballesteros, PH0-0001
Scott Kingery logo8S.Kingery, PR1-2000
Scott Kingery logo8S.Kingery, 3B1-2000
Pete Crow-Armstrong logo9P.Crow-Armstrong, CF2-5000

Phillies vs. Cubs Odds Comparison

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Phillies at Cubs Team Totals

MatchupOverUnder
Phillies
8-17
N/A
N/A
Cubs
16-9
N/A
N/A