Pirates vs. Cardinals Odds & Betting Predictions - May 21, 2026

Pirates at Cardinals

5:15 pm • CARD

Pittsburgh Pirates

St. Louis Cardinals

pitcher		team	era	w-l
D.May			4.81	3-4
B.Ashcraft			3.09	2-2

MatchupOpenSpreadTotalMoneyline
Pirates 25-24	-1.5	-1.5+135	o7.5+100	-125
Cardinals 28-20	u7.5	+1.5-161	u7.5-120	+105

Thursday 5:15 p.m.

May 21, 2026

Busch StadiumSt. Louis

68°Fahrenheit

0%Rain

7Wind

B.Ashcraft o5.5 Ks+127

0.79u

D.May u17.5 Outs+110

0.45u

J.Walker o1.5 Total Bases+130

$1.00

O.Cruz o1.5 Hits + Runs + RBIs-105

$1.05

B.Lowe o1.5 Hits + Runs + RBIs+100

D.May u17.5 Outs+120

0.83u

Under 8-115

1.15u

+15.64U L10 Days🔥📈

Under 8-115

0.58u

Bet to 7.5 (-112)

Over 7.5-112

0.56u

Pirates vs Cardinals: Wind Blowing In
Tanner McGrath•
May 21, 2026 UTC
The Leadoff: Trollo's MLB Breakdown and Bets for Thursday
Matt Trollo•
May 21, 2026 UTC

See more MLB Coverage

No props found

MLB Public Betting

Cardinals are 3-2 in their last 5 games.
Cardinals are 3-2 in their last 5 games against the spread
Cardinals are 15-8 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 12 of Cardinals' 25 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	30-18	15-10	15-8	3-3	27-15
Pirates	26-23	13-13	13-10	15-12	10-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	21-24-3	12-12-1	9-12-2	2-4	19-20-3
Pirates	26-22-1	16-10	10-12-1	16-11	9-11-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	28-20	13-12	15-8	3-3	25-17
Pirates	25-24	13-13	12-11	16-11	8-13

date	opponent	score	spread	over/under	moneyline
May 20th	PIT	L 0-7	+1.5 L	U 7.5	PIT -117
May 19th	PIT	W 9-6	+1.5 W	O 8	STL -113
May 17th	KC	L 0-2	+1.5 L	U 9.5	KC -120
May 16th	KC	W 4-2	-1.5 W	U 9	STL -112
May 16th	KC	W 5-4	+1.5 W	O 8.5	STL -108

Jared Jones
SP
Jones is out with elbow
Out

Lars Nootbaar
LF
Nootbaar is out with heel
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
RB.Ashcraft, P		2-2	3.09	1.048	9.11

HITTERS	AVG	OBP	SLG	HR
1O.Cruz, CF	.259	.327	.457	10
2B.Lowe, 2B	.250	.342	.542	12
3B.Reynolds, LF	.251	.380	.389	4
4S.Horwitz, 1B	.276	.381	.433	4
5K.Griffin, SS	.278	.333	.405	3
6M.Ozuna, DH	.179	.275	.305	5
7J.Mangum, RF	.259	.333	.284	0
8J.Triolo, 3B	.259	.310	.296	0
9H.Davis, C	.137	.241	.232	2

PITCHER		W-L	ERA	WHIP	K/9
RD.May, P		3-4	4.81	1.418	6.47

HITTERS	AVG	OBP	SLG	HR
1J.Wetherholt, 2B	.244	.364	.422	9
2I.Herrera, DH	.257	.384	.408	5
3A.Burleson, 1B	.286	.356	.462	7
4J.Walker, RF	.296	.368	.570	13
5N.Gorman, 3B	.234	.320	.377	6
6M.Winn, SS	.248	.324	.344	1
7N.Church, LF	.247	.282	.390	5
8P.Pages, C	.208	.257	.356	4
9V.Scott, CF	.190	.246	.267	2