Cardinals vs. Guardians Odds & Betting Predictions - June 27, 2025

Cardinals at Guardians

11:10 pm • Apple TV+
5 - 0
Starting Pitchers
pitcherteameraw-l
Luis L. Ortiz logoL.OrtizCleveland Guardians logo4.374-9
Sonny Gray logoS.GraySt. Louis Cardinals logo3.368-2

Cardinals at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
47-39
-1.5
-1.5+133
o8.5-111
-127
Guardians
40-42
u8.5
+1.5-162
u8.5-107
+106
location pinFriday 11:10 p.m.
June 27, 2025
Progressive FieldCleveland
Cardinals vs. Guardians Expert Picks
Under 8.5-105
0.48u
Backing Sonny Gray and Luis Ortiz, both of whom have solid underlying metrics. Gray has a 3.19 FIP and 3.11 xFIP with a career-low 4.9% walk rate. Ortiz with a 3.98 FIP and 3.64 xFIP with a career high 25.7% K%. Guardians also rolling out a more watered-down lineup without Jose Ramirez and Carlos Santana. Both teams have league-average bullpens so that’s why I’m willing to go the full total over the F5. Projecting this closer to 8.
Picks Office
Picks Office
Last 30d: 80-81-2 (-2.9u)
CLE +110
1u
Follow @PicksOffice on X for more
💰🦡 Jake
💰🦡 Jake
Last 30d: 87-99-4 (-0.1u)
Under 0.5 (1st Inn)-115
1u
Kyle Murray
Kyle Murray
Last 30d: 102-122-4 (+44.2u)
Under 8.5-104
1u
Boomer Betz
Boomer Betz
Last 30d: 284-290-5 (+15.4u)
S.Gray o5.5 Ks-120
0.83u
Bet Labs
Bet Labs
Last 30d: 51-40-1 (+6.4u)
STL -120
1u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 154-124-4 (+6.2u)
Under 8.5+100
1u
Under when home team shutout Overall: 592-446-50,57% (ROI:10%) Season:33-15-1,69% (ROI:31%)
Scott Rickenbach
Scott Rickenbach
Last 30d: 82-72-0 (-4.7u)
STL -130
0.77u
Kyle Murray
Kyle Murray
Last 30d: 102-122-4 (+44.2u)
S.Gray o5.5 Ks-130
1u
L.Ortiz o4.5 Ks-115
1u
Sean Zerillo
Sean Zerillo
Last 30d: 158-148-3 (+10.0u)
CLE +110
0.5u
Bet to +103
Over 8.5+100
0.5u
Bet to 9 (-105)

Cardinals vs. Guardians Previews & Analysis

  • Our 4 MLB Best Bets & Parlay for Friday article feature image

    Our 4 MLB Best Bets & Parlay for Friday

    Action Network Staff
    Jun 27, 2025 UTC
  • 2 MLB NRFI & YRFI Picks for Friday article feature image

    2 MLB NRFI & YRFI Picks for Friday

    Billy Ward
    Jun 27, 2025 UTC
  • Cardinals vs. Guardians: Bounce-Back Spot article feature image

    Cardinals vs. Guardians: Bounce-Back Spot

    Action Network Staff
    Jun 27, 2025 UTC
  • 2 PRO Systems Agree on Friday Pick article feature image

    2 PRO Systems Agree on Friday Pick

    Alex Kolodziej
    Jun 26, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Cardinals vs. Guardians Public Betting Percentages

Away Logo

Cardinals

Public

74%

Bets%

26%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
39-4317-2322-2015-1624-26
Cardinals
47-3923-2024-1916-2130-18

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
33-45-418-21-115-24-315-1618-28-4
Cardinals
44-39-323-19-121-20-220-15-223-24-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
40-4220-2020-2219-1221-29
Cardinals
47-3926-1721-2221-1625-23

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 26thTORL 0-6-1.5 LU 7.5TOR -136
Jun 25thTORW 5-4-1.5 LO 8CLE -125
Jun 24thTORL 6-10+1.5 LO 9TOR +112
Jun 22nd@ATHW 3-0-1.5 WU 9CLE -113
Jun 22nd@ATHW 4-2-1.5 WU 9.5CLE -135

Guardians vs. Cardinals Injury Updates

Guardians Injuries

  • Gabriel Arias
    SS

    Arias is out with leg

    Out

  • Ben Lively
    SP

    Lively is out with elbow

    Out

  • Shane Bieber
    SP

    Bieber is out with elbow

    Out

  • John Means
    SP

    Means is out with elbow

    Out

Cardinals Injuries

    Cardinals vs. Guardians Box Score
    Cardinals Player Stats
    Projected
    PITCHERPCIPKER
    Sonny Gray logoRS.Gray, P899110
    HITTERSH-ABRHRRBI
    Brendan Donovan logo1B.Donovan, 2B1-4000
    Masyn Winn logo2M.Winn, SS0-4100
    Alec Burleson logo3A.Burleson, RF2-4212
    Garrett Hampson logo3G.Hampson, RF0-0000
    Willson Contreras logo4W.Contreras, 1B1-3100
    Lars Nootbaar logo5L.Nootbaar, LF0-3000
    Nolan Arenado logo6N.Arenado, 3B2-4002
    Nolan Gorman logo7N.Gorman, DH0-4000
    Pedro Pages logo8P.Pages, C1-4111
    Victor Scott logo9V.Scott, CF0-4000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Luis L. Ortiz logoRL.Ortiz, P102754
    Jakob Junis logoRJ.Junis, P27111
    Erik Sabrowski logoLE.Sabrowski, P10120
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF0-4000
    Lane Thomas logo2L.Thomas, CF0-3000
    Kyle Manzardo logo3K.Manzardo, 1B0-3000
    David Fry logo4D.Fry, DH0-3000
    Daniel Schneemann logo5D.Schneemann, 3B0-3000
    Nolan Jones logo6N.Jones, RF1-3000
    Gabriel Arias logo7G.Arias, SS0-3000
    Bo Naylor logo8B.Naylor, C0-3000
    Angel Martinez logo9A.Martinez, 2B0-3000

    Cardinals vs. Guardians Odds Comparison

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    Cardinals at Guardians Team Totals

    MatchupOverUnder
    Cardinals
    47-39
    o4.5-101
    u4.5-127
    Guardians
    40-42
    o3.5-133
    u3.5+103