49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025
49ers at Seahawks
8:05 pm • FOX49ers at Seahawks Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 0-0 | -1.5 | -1.5-107 | o43.5-106 | -119 |
 Seahawks 0-0 | u45.5 | +1.5-114 | u43.5-112 | +100 |
Lumen FieldSeattle
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49ers vs. Seahawks Expert Picks
Nick Giffen
Last 30d: 13-65-0 (-3.3u)
Z.Charbonnet Anytime TD Scorer Yes+390
0.5u
Z.Charbonnet Last TD Scorer Yes+1700
0.1u
Grant Neiffer
Last 30d: 45-122-7 (+38.5u)
G.Kittle Anytime TD Scorer Yes+175
0.5u
Kenny Ducey
Last 30d: 10-2-0 (+8.0u)
SEA +1.5-110
1.1u
Brandon Anderson
Last 30d: 2-1-0 (+1.1u)
K.Walker o59.5 Rush Yds-115
0.75u
There's also one key matchup that's very worrying for San Francisco: Seattle's run game.
Klint Kubiak is the new play caller in Seattle, and if preseason is any indication, his presence could transform this Seahawks rushing attack. A young offensive line that was widely panned as consensus bottom-three in the league suddenly looked outstanding, and Seattle was ripping off big runs left and right.
San Francisco's pass defense was good last season, but the 49ers ranked bottom 10 by DVOA against the run and entire the season with a gaping hole at defensive tackle. The 49ers allowed the 5th most fantasy points to opposing RBs last season, letting 10 RBs rush for 70+ yards and giving up a league-high 18 rushing TDs to opposing RBs.
Kenneth Walker looks healthy and should get plenty of touches in Kubiak's system. He had a touchdown in both 49ers games last fall.
Let's back Walker to go over 59.5 yards, and as a slight escalator, we'll place a portion of our bet on Walker going over his rushing line and also finding the endzone at +323 (FanDuel).
Action Pod NFL Picks
Last 30d: 1-0-0 (+1.0u)
K.Walker o59.5 Rush Yds-115
1u
@wheatonbrando https://myaction.app/TqfB5ck7pWb
Jeremiah Rose
Last 30d: 16-15-2 (+1.7u)
C.McCaffrey Anytime TD Scorer Yes-120
0.1u
Promo Boost
Chris Gimino
Last 30d: 6-0-0 (+8.8u)
B.Purdy u32.5 Pass Att-115
1u
💰🦡 Jake
Last 30d: 79-95-9 (-18.1u)
SF -0.5 (1H)-110
1.1u
Ryan Sura
Last 30d: 42-46-5 (-6.2u)
G.Kittle o59.5 Rec Yds-110
1.1u
Royals Props
Last 30d: 5-5-0 (-1.0u)
G.Kittle o60.5 Rec Yds-125
1.25u
Fanatics
Top Shelf Action 🥃
Last 30d: 99-107-1 (-14.2u)
SEA +1.5-105
1.05u
Early season divisional underdogs
Overall: 130-66-6,66% (ROI:27%)
49ers vs. Seahawks Previews & Analysis
49ers vs. Seahawks Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Seahawks Public Betting Percentages
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Seahawks Injury Updates
49ers Injuries
- Demarcus RobinsonWR
Robinson is out with suspension
Out
- Christian McCaffreyRB
McCaffrey is questionable with calf
Questionable
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan WatkinsWR
Watkins is doubtful with ankle
Doubtful
- Jordan JamesRB
James is doubtful with finger
Doubtful
Seahawks Injuries
- Uchenna NwosuLB
Nwosu is out with knee
Out
- Dareke YoungWR
Young is out with hamstring
Out
- Jake BoboWR
Bobo is out with concussion
Out
Player Stats
- passing yards
-4320pyds - passing touchdowns-21ptd
- rushing yards
Kenneth Walker573ryds - rushing touchdowns
Zach Charbonnet8rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | ||
|---|---|---|---|---|---|
| QB | Sam Darnold | Drew Lock | Jalen Milroe | ||
| RB | Kenneth Walker | Zach Charbonnet | George Holani | Damien Martinez | Jacardia Wright |
| WR | Cooper Kupp | Dareke Young | |||
| TE | AJ Barner | Elijah Arroyo | Eric Saubert | Nick Kallerup | |
| LT | Charles Cross | Amari Kight | |||
| LG | Grey Zabel | Bryce Cabeldue | |||
| C | Olu Oluwatimi | Jalen Sundell | Federico Maranges | ||
| RG | Anthony Bradford | Christian Haynes | Mason Richman | ||
| RT | Abraham Lucas | Josh Jones | |||
| LDE | DeMarcus Lawrence | Derick Hall | Jared Ivey | Connor O'Toole | |
| RDE | Leonard Williams | Mike Morris | J.R. Singleton | ||
| WLB | Tyrice Knight | Patrick O'Connell | Jamie Sheriff | ||
| MLB | Ernest Jones | Drake Thomas | |||
| LCB | Josh Jobe | Nehemiah Pritchett | Shemar Jean-Charles | ||
| SS | Julian Love | Nick Emmanwori | Jerrick Reed | ||
| FS | Coby Bryant | D'Anthony Bell | Ty Okada | ||
| RCB | Riq Woolen | Shaquill Griffin | |||
| P | Michael Dickson | ||||
| H | Michael Dickson | ||||
| PR | Tory Horton | ||||
| KR | Tory Horton | Zach Charbonnet | |||
| LS | Chris Stoll | ||||
| K | Jason Myers | ||||
| NT | Byron Murphy | Johnathan Hankins | Brandon Pili | Quinton Bohanna | |
| NB | Devon Witherspoon | ||||
| RWR | Tory Horton | Ricky White | |||
| LOLB | Uchenna Nwosu | Boye Mafe | |||
| ROLB | Jamie Sheriff | Connor O'Toole | |||
| FB | Robbie Ouzts | Brady Russell | |||
| DT | Jarran Reed | Rylie Mills | |||
| LWR | Jaxon Smith-Njigba | Jake Bobo | Cody White | Tyrone Broden |
49ers vs. Seahawks Odds Comparison
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49ers at Seahawks Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 0-0 | N/A | N/A |
Seahawks 0-0 | N/A | N/A |