Chiefs vs. Giants Odds & Betting Predictions - September 22, 2025

I don't need to tell you why the Chiefs are better than the Giants — though I might need you to let me know why this game was chosen for Sunday Night Football? — so instead let's focus on the number grab here at -5.5 (FanDuel). There are two outcomes for the Chiefs this weekend. Either Kansas City beats Philadelphia in the Super Bowl rematch and gains bettors' confidence back, pushing this line to -6 or -7, maybe even past both key numbers… or the Chiefs lose again, fall to 0-2, and face an unprecedented-for-them kitchen sink spot against the lowly Giants in a game no one thinks they have any shot of blowing and dropping to 0-3. Either way, this line rises! Heck, just the Giants losing badly to the Cowboys could do that, and they've lost by at least five points in 15 of the last 18 meetings. There's another reason this line could move in our favor — we might get rookie QB Jaxson Dart making his debut, especially with a Sunday night audience on tap and Brian Daboll not wanting to get himself embarrassed or fired early. Any rookie QB debuting in primetime against an aggressive, blitzing Steve Spagnuolo is likely to struggle. Really, this is all about the -5.5. If this line somehow moves toward the Giants, we lose very little — four and five aren't particularly important key numbers, and there's no chance this ever gets to -3 or the Chiefs would get hammered. But if the lines goes the other way, both six and seven are key numbers in today's NFL, and we could even end up at -7.5 on the other side of both. Play the Chiefs now and stay ahead of the line move.