Colts vs. Chargers Odds & Betting Predictions - October 19, 2025

Colts at Chargers

8:05 pm • CBS

Indianapolis Colts

6-1

38 - 24

Los Angeles Chargers

4-3

MatchupOpenSpreadTotalMoneyline
Colts 6-1	+6	+2.5-106	o49-110	+120
Chargers 4-3	u45.5	-2.5-113	u49.5-112	-142

Sunday 8:05 p.m.

October 19, 2025

SoFi StadiumInglewood

Under 58.5 (Live)-110

0.5u

IND +130

0.65u

LAC -2.5-111

0.55u

D.Jones o15.5 Rush Yds-112

1.12u

One glaring trend: the Chargers are leaking QB rushing yards because of how they play defense. They live in light coverage shells and rush four, trying to win with pressure without sending extra bodies. That consistently squeezes the pocket without actually closing lanes, so when the QB bails he’s running into space instead of traffic. The Chargers have already allowed 23 QB scrambles for 187 yards and 9 first downs, that league-high scramble volume (13.8%) is a direct product of their 2-3-6 and 3-3-5 shells generating pressure without lane integrity. We’ve already seen the exact archetype punish this three straight weeks: Mahomes 57, Bo Nix 33, Geno 20. None of those were designed runs, they were “nothing there, pull it and go.” PropsMadness has that archetype undefeated vs this defense with a large over-margin. Jones fits the same archetype. He doesn’t need scheme to hand him yards — he runs when the door opens. With how the Chargers rush, two clean escapes can clear this number. The only way this loses is if he never leaves structure or converts those same lanes into sacks instead of yards. #PlayerProps

LAC -128

1.28u

LAC -125

1.5u

M.Pittman o49.5 Rec Yds-114

LAC -2.5-105

T.Warren o57.5 Rec Yds-114

0.88u

A.Pierce o2.5 Recs-102

0.98u

Both Teams To Make 33+ Yard FG -120

0.83u

IND +2.5-110

0.91u

X: PicksOffice

A.Mitchell Anytime TD Scorer Yes+500

0.4u

J.Taylor o88.5 Rush Yds-110

0.91u

IND +2-105

0.95u

Under 48.5-110

1.1u

D.Jones o14.5 Rush Yds-114

LAC -1.5-111

1.11u

O.Gadsden Anytime TD Scorer Yes+285

1.43u

@The_Oddsmaker https://myaction.app/MsfxZEmqyXb

J.Taylor 2+ TDs Yes+310

1.55u

@The_Oddsmaker https://myaction.app/MsfxZEmqyXb

Under 48.5-110

Obvious over soars under

K.Allen Anytime TD Scorer Yes+210

1.05u

Q.Johnston Anytime TD Scorer Yes+190

0.95u

J.Taylor 2+ TDs Yes+350

1.75u

LAC -125

1.25u

LAC -130

1.3u

LAC -130

1.3u

@Stuckey2 https://myaction.app/4ocNrlaxxXb

LAC -1.5-112

@sundaysixpack @Stuckey2 https://myaction.app/AOwwgtQewXb

LAC -1.5-111

1.11u

@Stuckey2 2 https://myaction.app/IHUc2sI9vXb

M.Pittman o51.5 Rec Yds-110

0.91u

K.Vidal Anytime TD Scorer Yes+100

0.1u

LAC -125

0.6u

LAC -108

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NFL Public Betting

Chargers are 3-2 in their last 5 games.
Chargers are 2-3 in their last 5 games against the spread
Chargers are 1-2 in their road games against the spread
The totals have gone OVER in 2 of Chargers' last 5 games
The totals have gone OVER in 1 of Chargers' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Chargers	3-4	1-2	1-2	2-4	1-0
Colts	5-2	3-1	2-1	3-1	2-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Chargers	3-4	1-2	1-2	2-4	1-0
Colts	4-3	2-2	2-1	2-2	2-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Chargers	4-3	N/A	N/A	3-3	1-0
Colts	6-1	N/A	N/A	4-0	2-1

date	opponent	score	spread	over/under	moneyline
Oct 12th	@MIA	W 29-27	-3.5 L	O 45.5	LAC -185
Oct 5th	WAS	L 10-27	-3 L	U 48.5	WAS -164
Sep 28th	@NYG	L 18-21	-6 L	U 42.5	NYG -280
Sep 21st	DEN	W 23-20	-2.5 W	U 45.5	LAC -155
Sep 16th	@LV	W 20-9	-3.5 W	U 46.5	LAC -190

Najee Harris
RB
Harris is out with achilles
Out

Hassan Haskins
RB
Haskins is questionable with chest
Questionable
Omarion Hampton
RB
Hampton is out with ankle
Out

Ashton Dulin
WR
Dulin is out with chest
Out
Tyler Goodson
RB
Goodson is out with groin
Out
Josh Downs
WR
Downs is out with concussion
Out

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Colts

Total

Chargers

401

Total Yards

445

Total Plays

6.9

Yards Per Play

Colts

Passing

Chargers

288

YDS

420

23/34

Comps/Atts

37/55

8.029

YPA

6.741

2/0

TDs/INTs

3/2

1/7

Sacks/Yards

3/29

Colts

Rushing

Chargers

120

Rush Yards

Attempts

5.217

YPC

3.375

TDs

Colts

Turnovers

Chargers

Fumbles Lost

Interceptions

Colts

Efficiency

Chargers

4/5 80%

Redzone

3/4 75%

5/11 0%

3rd Down

8/16 0%

3/3 0%

4th Down

3/4 0%

Colts

First Downs

Chargers

Total

Pass

Rush

Penalty

Colts

Misc

Chargers

3/42

Penalties/Yards

6/35

25:33

Possession

34:27

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MatchupOverUnder
Colts 6-1	o23.5-115	u23.5-108
Chargers 4-3	o25-116	u25-106

Colts vs. Chargers Odds & Betting Predictions - October 19, 2025

Colts at Chargers

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Colts

Public

Chargers

Bets%

Money%

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Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Chargers vs. Colts Injury Updates

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Colts vs. Chargers Odds Comparison

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