Packers vs. Browns Odds & Betting Predictions - September 21, 2025

Packers at Browns

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Green Bay Packers

@

Cleveland Browns

MatchupOpenSpreadTotalMoneyline
Packers 2-0	-6.5	-9-107	o42.5-110	-452
Browns 0-2	u43.5	+9-112	u42.5-110	+350

location pin

Sunday 5:00 p.m.

September 21, 2025

Huntington Bank FieldCleveland

thermometer image

74°Fahrenheit

rain image

27%Rain

wind image

9Wind

CLE +9-110

1u

Under 42.5-110

1.8u

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NFL Public Betting

Browns are 0-2 in their last 5 games.
Browns are 1-1 in their last 5 games against the spread
Browns are 0-1 in their road games against the spread
The totals have gone OVER in 1 of Browns' last 2 games
The totals have gone OVER in 0 of Browns' 1 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Browns	1-1	1-0	0-1	N/A	1-1
Packers	2-0	2-0	N/A	2-0	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Browns	1-1	0-1	1-0	N/A	1-1
Packers	0-2	0-2	N/A	0-2	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Browns	0-2	N/A	N/A	N/A	0-2
Packers	2-0	N/A	N/A	2-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@BAL	L 17-41	+12.5 L	O 46.5	BAL +640
Sep 7th	CIN	L 16-17	+4.5 W	U 47.5	CIN +185
Aug 23rd	LA	W 19-17	-10 L	U 37	CLE -550
Aug 16th	@PHI	W 22-13	+2.5 W	U 36.5	CLE +120
Aug 8th	@CAR	W 30-10	+5.5 W	O 33.5	CLE +210

Mike Hall
DT
Hall is out with knee
Out

Micah Parsons
DE
Parsons is questionable with back
Questionable
Nate Hobbs
CB
Hobbs is questionable with knee
Questionable
Zayne Anderson
S
Anderson is questionable with knee
Questionable
Christian Watson
WR
Watson is out with knee
Out
MarShawn Lloyd
RB
Lloyd is out with hamstring
Out
Barryn Sorrell
DE
Sorrell is questionable with knee
Questionable

See more NFL Injuries

passing yards
Joe Flacco
290
pyds
passing touchdowns
Joe Flacco
1
ptd
rushing yards
Dylan Sampson
29
ryds
rushing touchdowns
Raheim Sanders
1
rtd

	Starter	2ND	3RD	4TH
QB	Joe Flacco	Dillon Gabriel	Shedeur Sanders	Deshaun Watson
RB	Jerome Ford	Quinshon Judkins	Dylan Sampson	Ahmani Marshall
WR	Jamari Thrash	DeAndre Carter	Cade McDonald
TE	David Njoku	Harold Fannin	Blake Whiteheart	Brenden Bates	Sal Cannella
LT	Dawand Jones	Cornelius Lucas
LG	Joel Bitonio	Teven Jenkins
C	Ethan Pocic	Luke Wypler
RG	Wyatt Teller	Zak Zinter
RT	Jack Conklin
LDE	Alex Wright	Isaiah McGuire	Julian Okwara	K.J. Henry
RDE	Myles Garrett	Joe Tryon-Shoyinka	Cameron Thomas
WLB	Devin Bush	Jerome Baker	Winston Reid
MLB	Carson Schwesinger	Mohamoud Diabate	Easton Mascarenas-Arnold
LCB	Denzel Ward	Dom Jones
SS	Grant Delpit	Rayshawn Jenkins	Donovan McMillon
FS	Ronnie Hickman	Damontae Kazee	Christopher Edmonds
RCB	Greg Newsome
P	Corey Bojorquez
H	Corey Bojorquez
PR	DeAndre Carter	Kaden Davis
KR	DeAndre Carter	Kaden Davis
LS	Rex Sunahara
DT	Mason Graham	Mike Hall	Sam Kamara	Ralph Holley
LWR	Cedric Tillman	David Bell
NT	Maliek Collins	Shelby Harris	Adin Huntington
NB	Cameron Mitchell	Myles Harden	LaMareon James
RWR	Jerry Jeudy	Isaiah Bond	Kaden Davis
K	Andre Szmyt

Total

Passing

457

YDS

278

35/53

Comps/Atts

31/45

9.057

YPA

6.444

4/0

TDs/INTs

1/2

2/23

Sacks/Yards

2/12

Rushing

213

Rush Yards

49

55

Attempts

24

3.873

YPC

2.042

2

TDs

1

Turnovers

Fumbles Lost

0

Interceptions

2

Efficiency

6/9 66.67%

Redzone

2/3 66.67%

9/22 0%

3rd Down

9/16 0%

1/2 0%

4th Down

2/3 0%

First Downs

36

Total

22

22

Pass

13

10

Rush

5

4

Penalty

4

Misc

/

Penalties/Yards

/

Possession

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MatchupOverUnder
Packers 2-0	N/A	N/A
Browns 0-2	N/A	N/A