Titans vs. Broncos Odds & Betting Predictions - September 7, 2025

On the surface, this pick is absolutely crazy. The Broncos are 56-15-2 at home the first two weeks in their history, per Anthony Dabbundo, and now No. 1 pick Cam Ward will make his debut on the road against this nasty, attacking defense. Rookie QBs making their road debut in Week 1 are 8-21 SU, and 28 QBs selected No. 1 since the merger are 5-22-1 SU in their first start. So none of that is great. The Broncos were a playoff team, the Titans were 2-15 ATS, and this is a huge line. And that huge line is exactly why we're playing it. It's just way too soon to be this confident about one team being this good and another this bad. Almost any line this long is worth a play in Week 1, just as a bet on uncertainty, and there are a slow of trends saying the spread line is too long. This is the exact sort of opponent the Broncos blew out last season, so I'm not interested in just betting the Titans to keep it close. Tennessee has made big improvements on its offensive line, special teams, and of course, quarterback. If this is close, though, I'm going for it all. Bo Nix is only a sophomore himself, after all, and that goofy perfect 8-0 ATS and SU record he sported as a rookie just dying to be broken. This is a hero play that has no business cashing, but this game has no business sitting at +350 on the moneyline. I'll take a nibble.