Cardinals vs 49ers Odds NFL Week 4
| Cardinals Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+15 -110 | 44 -110o / -110u | +700 |
| 49ers Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-15 -110 | 44 -110o / -110u | -1100 |
We're taking a look at Cardinals vs. 49ers odds for their NFC West clash at Levi's Stadium.
The 49ers have been on a demolition path and the Cardinals are the next team in their way. However, the Cardinals are off to a surprisingly great start and are 3-0 against the spread (ATS).
Our Evan Abrams notes in his NFL Week 4 betting primer that the Cardinals are the first team in the Wild Card era to be a double-digit underdog in their fourth game after starting 3-0 ATS. The 49ers are -15 on the spread and an absurd -1100 on the moneyline at bet365 — can Arizona keep its streak going on Sunday afternoon?
Let's break down this Week 4 afternoon battle between Arizona and San Francisco and make a Cardinals vs. 49ers betting pick.
Cardinals vs. 49ers
Matchup Analysis
The 49ers entered the season with high expectations in a weak NFC. However, with Trey Lance getting traded and Brock Purdy coming off of a major injury, there was also a decent amount of uncertainty surrounding the most important position on this team.
Purdy and the rest of the 49ers offense have quickly put that uncertainty to bed.
The 49ers have scored exactly 30 points in all three of their games and are second in the league in offensive DVOA, trailing only the historically explosive Dolphins. San Francisco has utilized a perfectly balanced attack, with the third-best pass DVOA and fourth-best rush DVOA.
San Francisco's main weapons have picked up right where they left off — Christian McCaffrey trails only Justin Jefferson in rushing and receiving yards, and Deebo Samuel is ninth in all-purpose yards amongst wide receivers.
Brandon Aiyuk has also had a strong start to the season with 11 catches for 172 yards and two touchdowns in two games. He missed San Francisco's Week 3 matchup with an injury, but Kyle Shanahan has confirmed that Aiyuk will be back on Sunday.
The 49ers defense has been almost as dominant as the offense. The defense allowed a combined 19 points to the Steelers and Giants and are ranked as the fourth-best defense in the NFL, per DVOA.
Bet Arizona vs. San Francisco at FanDuel
Joshua Dobbs and the Cardinals offense have had a really strong start to the season. However, in their one road performance, Dobbs threw for just 132 yards in a loss to the Commanders. This will undoubtedly be his toughest test so far.
The Cardinals have made their living jumping out to early leads and trying to hang on in the second half. They are tied for third — with the 49ers — in first-half scoring, but are tied for last in second-half scoring.
With extra rest, I don’t expect San Francisco to have the same slow start other teams have had against the Cardinals. The 49ers defense should be prepared and the offense should start firing immediately, taking away the Cardinals’ opportunity to get a lead, run the ball and chew clock.
The 49ers played on Thursday Night Football, so they come into this game with 10 days of rest. Shanahan, as 49ers head coach, is an excellent 15-10 (60%) ATS when he has the rest advantage.
Cardinals vs. 49ers
Betting Picks & Predictions
The Cardinals have covered in every game this season, but there's no “ride-the-hot-hand” policy in the NFL like there can be in college football.
Teams that are 3-0 ATS are 36-49-2 (42.4%) in Week 4 since 2005. Eventually, the market adjusts to these teams as it's really hard to continue “defying the odds” in the NFL.
I think the 49ers will jump out to an early lead and use McCaffrey to grind out long drives. Arizona's defense ranks 19th in rush DVOA and should get worn down.
Eventually, the 49ers will bust open the floodgates. There is a false narrative that big favorites in the NFL are a bad bet, but since 2015, home favorites of 14 or more are 30-24-2 (55.6%) ATS. Shanahan, specifically, is 2-0 ATS in this spot.
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