49ers vs. Saints Odds & Betting Predictions - September 14, 2025
49ers at Saints
5:00 pm • FOX49ers at Saints Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 1-0 | -7 | -3-110 | o40.5-110 | -165 |
 Saints 0-1 | u44.5 | +3-110 | u40.5-110 | +140 |
Caesars SuperdomeNew Orleans
49ers vs. Saints Expert Picks
Kenny Ducey
Last 30d: 12-10-1 (+1.6u)
SF -4.5-110
1.1u
Mjaybrod
Last 30d: 15-33-0 (-20.0u)
Over 42.5-110
1u
Obvious under of the week
NO o18.5 Team Total-110
1u
Scored 13 vs a worse defense
Matthew Freedman
Last 30d: 9-5-0 (+1.5u)
C.McCaffrey Anytime TD Scorer Yes-165
1.65u
Projection: 0.84 TDs, -252.3. For more, check out the Fantasy Life player projections.
Cam Is Money
Last 30d: 42-67-1 (-18.4u)
NO +6.5-113
1u
FTN Fantasy
Last 30d: 57-94-0 (-39.9u)
SF -6.5-105
1u
49ers vs. Saints Previews & Analysis
49ers vs. Saints Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Saints Public Betting Percentages
Betting Trends
- Saints are 0-1 in their last 5 games.
- Saints are 0-1 in their last 5 games against the spread
- The totals have gone OVER in 0 of Saints' last 1 games
- The totals have gone OVER in 0 of Saints' 1 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Saints vs. 49ers Injury Updates
Saints Injuries
- Taysom HillTE
Hill is out with knee
Out
- Chase YoungDE
Young is out with calf
Out
- Trevor PenningOL
Penning is out with toe
Out
- Jordan HowdenDB
Howden is questionable with oblique
Questionable
49ers Injuries
- Demarcus RobinsonWR
Robinson is out with suspension
Out
- George KittleTE
Kittle is out with hamstring
Out
- Eddy PineiroK
Pineiro is questionable with knee
Questionable
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jauan JenningsWR
Jennings is questionable with shoulder
Questionable
- Brock PurdyQB
Purdy is doubtful with toe
Doubtful
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan WatkinsWR
Watkins is doubtful with ankle
Doubtful
- Jordan JamesRB
James is doubtful with finger
Doubtful
Player Stats
- passing yards
Spencer Rattler214pyds - passing touchdowns
--ptd - rushing yards
Alvin Kamara45ryds - rushing touchdownsAlvin Kamara1rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |||
|---|---|---|---|---|---|---|
| QB | Spencer Rattler | Tyler Shough | Jake Haener | |||
| RB | Alvin Kamara | Kendre Miller | Velus Jones | Devin Neal | ||
| WR | Devaughn Vele | Cedrick Wilson | ||||
| TE | Juwan Johnson | Foster Moreau | Taysom Hill | Treyton Welch | Jack Stoll | Moliki Matavao |
| LT | Kelvin Banks | Landon Young | Barry Wesley | |||
| LG | Trevor Penning | Dillon Radunz | Easton Kilty | |||
| C | Erik McCoy | Luke Fortner | ||||
| RG | Cesar Ruiz | Torricelli Simpkins | ||||
| RT | Taliese Fuaga | |||||
| RDE | Nathan Shepherd | Jonathan Bullard | Jonah Williams | |||
| WLB | Pete Werner | Jaylan Ford | Nephi Sewell | |||
| MLB | Demario Davis | Danny Stutsman | Nephi Sewell | |||
| LCB | Isaac Yiadom | Quincy Riley | Dalys Beanum | |||
| SS | Justin Reid | Jordan Howden | Terrell Burgess | |||
| FS | Julian Blackmon | Jonas Sanker | Elliott Davison | |||
| RCB | Kool-Aid McKinstry | Rejzohn Wright | ||||
| P | Kai Kroeger | |||||
| H | Kai Kroeger | |||||
| PR | Rashid Shaheed | Cedrick Wilson | Jayden Price | |||
| KR | Rashid Shaheed | Velus Jones | Kendre Miller | Jayden Price | ||
| LS | Zach Wood | |||||
| RWR | Rashid Shaheed | Brandin Cooks | ||||
| LWR | Chris Olave | Mason Tipton | Kevin Austin | |||
| ROLB | Carl Granderson | Chris Rumph | ||||
| DT | Bryan Bresee | Vernon Broughton | ||||
| NB | Alontae Taylor | Ugo Amadi | Jayden Price | |||
| NT | Davon Godchaux | Khristian Boyd | John Ridgeway | |||
| LOLB | Chase Young | Cameron Jordan | ||||
| K | Blake Grupe | Charlie Smyth |
Team Stats
49ers vs. Saints Odds Comparison
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49ers at Saints Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 1-0 | N/A | N/A |
Saints 0-1 | N/A | N/A |